Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis CNS3/4A protease
Liverton, Nigel J., Holloway, M. Katharine, McCauley, John A., Rudd, Michael T., Butcher, John W., Carroll, Steven S., DiMuzio, Jillian, Fandozzi, Christine, Gilbert, Kevin F., Mao, Shi-Shan, Mclntyre, Charles J., Nguyen, Kevin T., Romano, Joseph J., Stahlhut, Mark, Wan, Bang-Lin, Olsen, David B., Vacca, Joseph P.
Published in Journal of the American Chemical Society (09.04.2008)
Published in Journal of the American Chemical Society (09.04.2008)
Get full text
Journal Article
L-687,908, a potent hydroxyethylene containing HIV protease inhibitor
Vacca, Joseph P, Guare, J. P, DeSolms, S. J, Sanders, W. M, Giuliani, E. A, Young, S. D, Darke, P. L, Sigal, I. S, Schleif, W. A
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
Get full text
Journal Article
A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase
Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, Fisher, Thorsten E., Embrey, Mark, Guare, James P., Egbertson, Melissa S., Vacca, Joseph P., Huff, Joel R., Felock, Peter J., Witmer, Marc V., Stillmock, Kara A., Danovich, Robert, Grobler, Jay, Miller, Michael D., Espeseth, Amy S., Jin, Lixia, I-Wu Chen, Lin, Jiunn H., Kassahun, Kelem, Ellis, Joan D., Wong, Bradley K., Xu, Wei, Pearson, Paul G., Schleif, William A., Cortese, Riccardo, Emini, Emilio, Summa, Vincenzo, Holloway, M. Katharine, Young, Steven D., Coffin, John M.
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2004)
Get full text
Journal Article
Antithrombotic Efficacy of Thrombin Inhibitor L-374,087: Intravenous Activity in a Primate Model of Venous Thrombus Extension and Oral Activity in a Canine Model of Primary Venous and Coronary Artery Thrombosis
Cook, J J, Gardell, S J, Holahan, M A, Sitko, G R, Stump, G L, Wallace, A A, Gilberto, D B, Hare, T R, Krueger, J A, Dyer, D L, Sanderson, P E, Vacca, J P, Shafer, J A, Lynch, Jr, J J
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
Journal Article
Metabolite–P450 Complex Formation by Methylenedioxyphenyl HIV Protease Inhibitors in Rat and Human Liver Microsomes
Chiba, Masato, Nishime, Joy A, Chen, I-Wu, Vastag, Kari J, Sahly, Yousif S, Kim, Byeong Moon, Dorsey, Bruce D, Vacca, Joseph P, Lin, Jiunn H
Published in Biochemical pharmacology (15.07.1998)
Published in Biochemical pharmacology (15.07.1998)
Get full text
Journal Article
Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitors
Dorsey, Bruce D., McDaniel, Stacey L., Levin, Rhonda B., Vacca, Joseph P., Darke, Paul L., Zuga, Joan A., Emini, Emilio A., Schleif, William A., Lin, Jiunn H., Chen, I-W., Holloway, M.Katharine, Anderson, Paul S., Huff, Joel R.
Published in Bioorganic & medicinal chemistry letters (01.12.1994)
Published in Bioorganic & medicinal chemistry letters (01.12.1994)
Get full text
Journal Article
A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site
Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny, deSolms, S. Jane, Gaffin, Neil, Ghosh, Arun K, Giuliani, Elizabeth A, Graham, Samuel L, Guare, James P, Hungate, Randall W, Lyle, Terry A, Sanders, William M, Tucker, Thomas J, Wiggins, Mark, Wiscount, Catherine M, Woltersdorf, Otto W, Young, Steven D, Darke, Paul L, Zugay, Joan A
Published in Journal of medicinal chemistry (24.05.1996)
Published in Journal of medicinal chemistry (24.05.1996)
Get full text
Journal Article
Discovery of pyrrolidine-based I2-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency
Stachel, Shawn J, Steele, Thomas G, Petrocchi, Alessia, Haugabook, Sharie J, McGaughey, Georgia, Holloway, MKatharine, Allison, Timothy, Munshi, Sanjeev, Zuck, Paul, Colussi, Dennis, Tugasheva, Katherine, Wolfe, Abigail, Graham, Samuel L, Vacca, Joseph P
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Get full text
Journal Article
Discovery and evaluation of potent P-1 aryl heterocycle-based thrombin inhibitors
Young, MB, Barrow, JC, Glass, KL, Lundell, GF, Newton, CL, Pellicore, JM, Rittle, KE, Selnick, HG, Stauffer, KJ, Vacca, JP, Williams, PD, Bohn, D, Clayton, FC, Cook, JJ, Krueger, JA, Kuo, LC, Lewis, SD, Lucas, BJ, McMasters, DR, Miller-Stein, C, Pietrak, BL, Wallace, AA, White, RB, Wong, B, Yan, YW, Nantermet, PG
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
Get full text
Journal Article