Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
Verstovsek, Srdan, Kantarjian, Hagop, Mesa, Ruben A, Pardanani, Animesh D, Cortes-Franco, Jorge, Thomas, Deborah A, Estrov, Zeev, Fridman, Jordan S, Bradley, Edward C, Erickson-Viitanen, Susan, Vaddi, Kris, Levy, Richard, Tefferi, Ayalew
Published in The New England journal of medicine (16.09.2010)
Published in The New England journal of medicine (16.09.2010)
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Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Quintás-Cardama, Alfonso, Vaddi, Kris, Liu, Phillip, Manshouri, Taghi, Li, Jun, Scherle, Peggy A, Caulder, Eian, Wen, Xiaoming, Li, Yanlong, Waeltz, Paul, Rupar, Mark, Burn, Timothy, Lo, Yvonne, Kelley, Jennifer, Covington, Maryanne, Shepard, Stacey, Rodgers, James D, Haley, Patrick, Kantarjian, Hagop, Fridman, Jordan S, Verstovsek, Srdan
Published in Blood (15.04.2010)
Published in Blood (15.04.2010)
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JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response
Kleppe, Maria, Kwak, Minsuk, Koppikar, Priya, Riester, Markus, Keller, Matthew, Bastian, Lennart, Hricik, Todd, Bhagwat, Neha, McKenney, Anna Sophia, Papalexi, Efthymia, Abdel-Wahab, Omar, Rampal, Raajit, Marubayashi, Sachie, Chen, Jonathan J, Romanet, Vincent, Fridman, Jordan S, Bromberg, Jacqueline, Teruya-Feldstein, Julie, Murakami, Masato, Radimerski, Thomas, Michor, Franziska, Fan, Rong, Levine, Ross L
Published in Cancer discovery (01.03.2015)
Published in Cancer discovery (01.03.2015)
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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Yue, Eddy W, Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Emm, Tom, Scherle, Peggy A, Metcalf, Brian, Combs, Andrew P
Published in ACS medicinal chemistry letters (11.05.2017)
Published in ACS medicinal chemistry letters (11.05.2017)
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Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
Maude, Shannon L., Tasian, Sarah K., Vincent, Tiffaney, Hall, Junior W., Sheen, Cecilia, Roberts, Kathryn G., Seif, Alix E., Barrett, David M., Chen, I-Ming, Collins, J. Racquel, Mullighan, Charles G., Hunger, Stephen P., Harvey, Richard C., Willman, Cheryl L., Fridman, Jordan S., Loh, Mignon L., Grupp, Stephan A., Teachey, David T.
Published in Blood (25.10.2012)
Published in Blood (25.10.2012)
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Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Liu, Xiangdong, Shin, Niu, Koblish, Holly K., Yang, Gengjie, Wang, Qian, Wang, Kathy, Leffet, Lynn, Hansbury, Michael J., Thomas, Beth, Rupar, Mark, Waeltz, Paul, Bowman, Kevin J., Polam, Padmaja, Sparks, Richard B., Yue, Eddy W., Li, Yanlong, Wynn, Richard, Fridman, Jordan S., Burn, Timothy C., Combs, Andrew P., Newton, Robert C., Scherle, Peggy A.
Published in Blood (29.04.2010)
Published in Blood (29.04.2010)
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Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
Fridman, Jordan S, Scherle, Peggy A, Collins, Robert, Burn, Timothy C, Li, Yanlong, Li, Jun, Covington, Maryanne B, Thomas, Beth, Collier, Paul, Favata, Margaret F, Wen, Xiaoming, Shi, Jack, McGee, Ryan, Haley, Patrick J, Shepard, Stacey, Rodgers, James D, Yeleswaram, Swamy, Hollis, Greg, Newton, Robert C, Metcalf, Brian, Friedman, Steven M, Vaddi, Kris
Published in The Journal of immunology (1950) (01.05.2010)
Published in The Journal of immunology (1950) (01.05.2010)
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Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors
Koblish, Holly K, Hansbury, Michael J, Bowman, Kevin J, Yang, Gengjie, Neilan, Claire L, Haley, Patrick J, Burn, Timothy C, Waeltz, Paul, Sparks, Richard B, Yue, Eddy W, Combs, Andrew P, Scherle, Peggy A, Vaddi, Kris, Fridman, Jordan S
Published in Molecular cancer therapeutics (01.02.2010)
Published in Molecular cancer therapeutics (01.02.2010)
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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
Zhou, Bin-Bing S., Peyton, Michael, He, Biao, Liu, Changnian, Girard, Luc, Caudler, Eian, Lo, Yvonne, Baribaud, Frederic, Mikami, Iwao, Reguart, Noemi, Yang, Gengjie, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Gazdar, Adi F., Friedman, Steven M., Jablons, David M., Newton, Robert C., Fridman, Jordan S., Minna, John D., Scherle, Peggy A.
Published in Cancer cell (01.07.2006)
Published in Cancer cell (01.07.2006)
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Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation
Fridman, Jordan S., Scherle, Peggy A., Collins, Robert, Burn, Timothy, Neilan, Claire L., Hertel, Denise, Contel, Nancy, Haley, Patrick, Thomas, Beth, Shi, Jack, Collier, Paul, Rodgers, James D., Shepard, Stacey, Metcalf, Brian, Hollis, Gregory, Newton, Robert C., Yeleswaram, Swamy, Friedman, Steven M., Vaddi, Kris
Published in Journal of investigative dermatology (01.09.2011)
Published in Journal of investigative dermatology (01.09.2011)
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Journal Article
Dissecting p53 tumor suppressor functions in vivo
Schmitt, Clemens A, Fridman, Jordan S, Yang, Meng, Baranov, Eugene, Hoffman, Robert M, Lowe, Scott W
Published in Cancer cell (01.04.2002)
Published in Cancer cell (01.04.2002)
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Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer
Fridman, Jordan S, Caulder, Eian, Hansbury, Michael, Liu, Xiangdong, Yang, Genjie, Wang, Qian, Lo, Yvonne, Zhou, Bin-Bing, Pan, Maxwell, Thomas, Sufi M, Grandis, Jennifer R, Zhuo, Jincong, Yao, Wenqing, Newton, Robert C, Friedman, Steven M, Scherle, Peggy A, Vaddi, Kris
Published in Clinical cancer research (15.03.2007)
Published in Clinical cancer research (15.03.2007)
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An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
Hannon, Gregory J, Lowe, Scott W, Hemann, Michael T, Fridman, Jordan S, Zilfou, Jack T, Hernando, Eva, Paddison, Patrick J, Cordon-Cardo, Carlos
Published in Nature genetics (01.03.2003)
Published in Nature genetics (01.03.2003)
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Journal Article
INCB16562, a JAK1/2 Selective Inhibitor, Is Efficacious against Multiple Myeloma Cells and Reverses the Protective Effects of Cytokine and Stromal Cell Support
Li, Jun, Favata, Margaret, Kelley, Jennifer A., Caulder, Eian, Thomas, Beth, Wen, Xiaoming, Sparks, Richard B., Arvanitis, Ari, Rogers, James D., Combs, Andrew P., Vaddi, Kris, Solomon, Kimberly A., Scherle, Peggy A., Newton, Robert, Fridman, Jordan S.
Published in Neoplasia (New York, N.Y.) (01.01.2010)
Published in Neoplasia (New York, N.Y.) (01.01.2010)
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Journal Article
Loss of p53 Impedes the Antileukemic Response to BCR-ABL Inhibition
Wendel, Hans-Guido, de Stanchina, Elisa, Cepero, Enriqué, Ray, Sagarika, Emig, Michael, Fridman, Jordan S., Veach, Darren R., Bornmann, William G., Clarkson, Bayard, McCombie, W. Richard, Kogan, Scott C., Hochhaus, Andreas, Lowe, Scott W.
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2006)
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Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
Burger, Renate, Le Gouill, Steven, Tai, Yu-Tzu, Shringarpure, Reshma, Tassone, Pierfrancesco, Neri, Paola, Podar, Klaus, Catley, Laurence, Hideshima, Teru, Chauhan, Dharminder, Caulder, Eian, Neilan, Claire L, Vaddi, Kris, Li, Jun, Gramatzki, Martin, Fridman, Jordan S, Anderson, Kenneth C
Published in Molecular cancer therapeutics (01.01.2009)
Published in Molecular cancer therapeutics (01.01.2009)
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Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab
Liu, Xiangdong, Fridman, Jordan S., Wang, Qian, Caulder, Eian, Yang, Gengjie, Covington, Maryanne, Liu, Changnian, Marando, Cindy, Zhuo, Jincong, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Newton, Robert C., Scherle, Peggy A., Friedman, Steven M.
Published in Cancer biology & therapy (01.06.2006)
Published in Cancer biology & therapy (01.06.2006)
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Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Liu, Phillip C C, Caulder, Eian, Li, Jun, Waeltz, Paul, Margulis, Alex, Wynn, Richard, Becker-Pasha, Mary, Li, Yanlong, Crowgey, Erin, Hollis, Gregory, Haley, Patrick, Sparks, Richard B, Combs, Andrew P, Rodgers, James D, Burn, Timothy C, Vaddi, Kris, Fridman, Jordan S
Published in Clinical cancer research (15.11.2009)
Published in Clinical cancer research (15.11.2009)
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A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3
XIANGDONG LIU, QIAN WANG, BOER, Jason, DIAMOND, Sharon, CHUNHONG HE, MEIZHONG XU, JINCONG ZHUO, WENQING YAO, NEWTON, Robert C, SCHERLE, Peggy A, GENGJIE YANG, MARANDO, Cindy, KOBLISH, Holly K, HALL, Leslie M, FRIDMAN, Jordan S, BEHSHAD, Elham, WYNN, Richard, YU LI
Published in Clinical cancer research (15.11.2011)
Published in Clinical cancer research (15.11.2011)
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