Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
Cisar, Justin S, Weber, Olivia D, Clapper, Jason R, Blankman, Jacqueline L, Henry, Cassandra L, Simon, Gabriel M, Alexander, Jessica P, Jones, Todd K, Ezekowitz, R. Alan B, O’Neill, Gary P, Grice, Cheryl A
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Published in Journal of medicinal chemistry (25.10.2018)
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Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones
van Oeveren, Arjan, Pio, Barbara A., Tegley, Christopher M., Higuchi, Robert I., Wu, Min, Jones, Todd K., Marschke, Keith B., Negro-Vilar, Andrés, Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines
Hamann, Lawrence G, Higuchi, Robert I, Zhi, Lin, Edwards, James P, Wang, Xiao-Ning, Marschke, Keith B, Kong, James W, Farmer, Luc J, Jones, Todd K
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Published in Journal of medicinal chemistry (12.02.1998)
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Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators
Clapper, Jason R, Henry, Cassandra L, Niphakis, Micah J, Knize, Anna M, Coppola, Aundrea R, Simon, Gabriel M, Ngo, Nhi, Herbst, Rachel A, Herbst, Dylan M, Reed, Alex W, Cisar, Justin S, Weber, Olivia D, Viader, Andreu, Alexander, Jessica P, Cunningham, Mark L, Jones, Todd K, Fraser, Iain P, Grice, Cheryl A, Ezekowitz, R Alan B, O'Neill, Gary P, Blankman, Jacqueline L
Published in The Journal of pharmacology and experimental therapeutics (01.12.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2018)
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Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors
Choe, Jun-Young, Nelson, Scott W., Arienti, Kristen L., Axe, Frank U., Collins, Tassie L., Jones, Todd K., Kimmich, Rachel D.A., Newman, Michael J., Norvell, Karl, Ripka, William C., Romano, Suzanne J., Short, Kevin M., Slee, Deborah H., Fromm, Herbert J., Honzatko, Richard B.
Published in The Journal of biological chemistry (19.12.2003)
Published in The Journal of biological chemistry (19.12.2003)
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Total synthesis of the macrolide antibiotic cytovaricin
Evans, David A, Kaldor, Stephen W, Jones, Todd K, Clardy, Jon, Stout, Thomas J
Published in Journal of the American Chemical Society (01.09.1990)
Published in Journal of the American Chemical Society (01.09.1990)
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Library Enhancement through the Wisdom of Crowds
Hack, Michael D, Rassokhin, Dmitrii N, Buyck, Christophe, Seierstad, Mark, Skalkin, Andrew, ten Holte, Peter, Jones, Todd K, Mirzadegan, Taraneh, Agrafiotis, Dimitris K
Published in Journal of chemical information and modeling (27.12.2011)
Published in Journal of chemical information and modeling (27.12.2011)
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Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis
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Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4- f]quinoline derivatives as progesterone receptor modulators
Zhi, Lin, Tegley, Christopher M, Pio, Barbara, Edwards, James P, Jones, Todd K, Marschke, Keith B, Mais, Dale E, Risek, Boris, Schrader, William T
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
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A practical enantioselective synthesis of .alpha.,.alpha.-diaryl-2-pyrrolidinemethanol. Preparation and chemistry of the corresponding oxazaborolidines
Mathre, David J, Jones, Todd K, Xavier, Lyndon C, Blacklock, Thomas J, Reamer, Robert A, Mohan, Julie J, Jones, E. Tracy Turner, Hoogsteen, Karst, Baum, Mary W, Grabowski, E. J. J
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Published in Journal of organic chemistry (01.01.1991)
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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains
Wiener, John J.M., Gomez, Laurent, Venkatesan, Hariharan, Santillán, Alejandro, Allison, Brett D., Schwarz, Kimberly L., Shinde, Shirin, Tang, Liu, Hack, Michael D., Morrow, Brian J., Motley, S. Timothy, Goldschmidt, Raul M., Shaw, Karen Joy, Jones, Todd K., Grice, Cheryl A.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore
Pooley, Charlotte L. F, Edwards, James P, Goldman, Mark E, Wang, Ming-Wei, Marschke, Keith B, Crombie, Diane L, Jones, Todd K
Published in Journal of medicinal chemistry (27.08.1998)
Published in Journal of medicinal chemistry (27.08.1998)
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Design of Concise, Scalable Route to a Cholecystokinin 1 (CCK 1) Receptor Antagonist
Liang, Jimmy T, Mani, Neelakandha S, Jones, Todd K
Published in Journal of organic chemistry (26.10.2007)
Published in Journal of organic chemistry (26.10.2007)
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Preparation, Resolution, and Biological Evaluation of 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists
Edwards, James P, Zhi, Lin, Pooley, Charlotte L. F, Tegley, Christopher M, West, Sarah J, Wang, Ming-Wei, Gottardis, Marco M, Pathirana, Charles, Schrader, William T, Jones, Todd K
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Non-imidazole heterocyclic histamine H3 receptor antagonists
WENYING CHAI, BREITENBUCHER, J. Guy, JONES, Todd K, KWOK, Annette, XIAOBING LI, WONG, Victoria, CARRUTHERS, Nicholas I, LOVENBERG, Timothy W, MAZUR, Curt, WILSON, Sandy J, AXE, Frank U
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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Total synthesis of immunosuppressant (-)-FK-506
Jones, Todd K, Mills, S. G, Reamer, R. A, Askin, D, Desmond, R, Volante, R. P, Shinkai, I
Published in Journal of the American Chemical Society (01.02.1989)
Published in Journal of the American Chemical Society (01.02.1989)
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Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6- g]quinolines
Kong, James W, Hamann, Lawrence G, Ruppar, Daniel A, Edwards, James P, Marschke, Keith B, Jones, Todd K
Published in Bioorganic & medicinal chemistry letters (06.03.2000)
Published in Bioorganic & medicinal chemistry letters (06.03.2000)
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Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors
Wiener, Danielle K., Lee-Dutra, Alice, Bembenek, Scott, Nguyen, Steven, Thurmond, Robin L., Sun, Siquan, Karlsson, Lars, Grice, Cheryl A., Jones, Todd K., Edwards, James P.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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