Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen
MACDONALD, Simon J. F, WATSON, Keith G, INGLIS, Graham G. A, JIN, Betty, JONES, Haydn T, MCCONNELL, Darryl B, MASON, Andy M, NGUYEN, Van, OWENS, Ian J, PARRY, Nigel, REECE, Phillip A, SHANAHAN, Stephen E, CAMERON, Rachel, SMITH, Donna, WU, Wen-Yang, TUCKER, Simon P, CHALMERS, David K, DEMAINE, Derek A, FENTON, Rob J, GOWER, David, HAMBLIN, J. Nicole, HAMILTON, Stephanie, HART, Graham J
Published in Antimicrobial Agents and Chemotherapy (01.12.2004)
Published in Antimicrobial Agents and Chemotherapy (01.12.2004)
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Journal Article
Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series
Barker, Mike, Clackers, Margaret, Copley, Royston, Demaine, Derek A, Humphreys, Davina, Inglis, Graham G. A, Johnston, Michael J, Jones, Haydn T, Haase, Michael V, House, David, Loiseau, Richard, Nisbet, Lesley, Pacquet, Francois, Skone, Philip A, Shanahan, Stephen E, Tape, Dan, Vinader, Victoria M, Washington, Melanie, Uings, Iain, Upton, Richard, McLay, Iain M, Macdonald, Simon J. F
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
Dimeric Zanamivir Conjugates with Various Linking Groups Are Potent, Long-Lasting Inhibitors of Influenza Neuraminidase Including H5N1 Avian Influenza
Macdonald, Simon J. F, Cameron, Rachel, Demaine, Derek A, Fenton, Rob J, Foster, Graham, Gower, David, Hamblin, J. Nicole, Hamilton, Stephanie, Hart, Graham J, Hill, Alan P, Inglis, Graham G. A, Jin, Betty, Jones, Haydn T, McConnell, Darryl B, McKimm-Breschkin, Jennifer, Mills, Gail, Nguyen, Van, Owens, Ian J, Parry, Nigel, Shanahan, Stephen E, Smith, Donna, Watson, Keith G, Wu, Wen-Yang, Tucker, Simon P
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Journal Article
Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity
Biggadike, Keith, Boudjelal, Mohamed, Clackers, Margaret, Coe, Diane M, Demaine, Derek A, Hardy, George W, Humphreys, Davina, Inglis, Graham G. A, Johnston, Michael J, Jones, Haydn T, House, David, Loiseau, Richard, Needham, Deborah, Skone, Philip A, Uings, Iain, Veitch, Gemma, Weingarten, Gordon G, McLay, Iain M, Macdonald, Simon J. F
Published in Journal of medicinal chemistry (27.12.2007)
Published in Journal of medicinal chemistry (27.12.2007)
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Journal Article
Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists
Barnett, Heather A., Coe, Diane M., Cooper, Tony W.J., Jack, Torquil I., Jones, Haydn T., Macdonald, Simon J.F., McLay, Iain M., Rayner, Natalie, Sasse, Rosemary Z., Shipley, Tracy J., Skone, Phil A., Somers, Graham I., Taylor, Simon, Uings, Iain J., Woolven, James M., Weingarten, Gordon G.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists
Biggadike, Keith, Caivano, Matilde, Clackers, Margaret, Coe, Diane M., Hardy, George W., Humphreys, Davina, Jones, Haydn T., House, David, Miles-Williams, Annette, Skone, Philip A., Uings, Iain, Weller, Vicki, McLay, Iain M., Macdonald, Simon J.F.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method
Barker, Mike, Clackers, Margaret, Demaine, Derek A, Humphreys, Davina, Johnston, Michael J, Jones, Haydn T, Pacquet, Francois, Pritchard, John M, Salter, Mark, Shanahan, Stephen E, Skone, Philip A, Vinader, Victoria M, Uings, Iain, McLay, Iain M, Macdonald, Simon J. F
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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Journal Article
Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics
Clackers, Margaret, Coe, Diane M., Demaine, Derek A., Hardy, George W., Humphreys, Davina, Inglis, Graham G.A., Johnston, Michael J., Jones, Haydn T., House, David, Loiseau, Richard, Minick, Doug J., Skone, Philip A., Uings, Iain, McLay, Iain M., Macdonald, Simon J.F.
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols
Keeling, Steven P., Campbell, Ian B., Coe, Diane M., Cooper, Tony W.J., Hardy, George W., Jack, Torquil I., Jones, Haydn T., Needham, Deborah, Shipley, Tracy J., Skone, Philip A., Sutton, Peter W., Weingarten, Gordon A., Macdonald, Simon J.F.
Published in Tetrahedron letters (18.08.2008)
Published in Tetrahedron letters (18.08.2008)
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Journal Article
Efficient synthesis of an alpha-trifluoromethyl-alpha-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF(3)-substituted tertiary alcohols
Keeling, Steven P., Campbell, Ian B., Coe, Diane M., Cooper, Tony W. J., Hardy, George W., Jack, Torquil I., Jones, Haydn T., Needham, Deborah, Shipley, Tracy J., Skone, Philip A., Sutton, Peter W., Weingarten, Gordon A., Macdonald, Simon J. F.
Published in Tetrahedron letters (18.08.2008)
Published in Tetrahedron letters (18.08.2008)
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Journal Article
Local Latent Space Bayesian Optimization over Structured Inputs
Maus, Natalie, Jones, Haydn T, Moore, Juston S, Kusner, Matt J, Bradshaw, John, Gardner, Jacob R
Year of Publication 27.01.2022
Year of Publication 27.01.2022
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Journal Article
Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF 3-substituted tertiary alcohols
Keeling, Steven P., Campbell, Ian B., Coe, Diane M., Cooper, Tony W.J., Hardy, George W., Jack, Torquil I., Jones, Haydn T., Needham, Deborah, Shipley, Tracy J., Skone, Philip A., Sutton, Peter W., Weingarten, Gordon A., Macdonald, Simon J.F.
Published in Tetrahedron letters (2008)
Published in Tetrahedron letters (2008)
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Journal Article
Local Latent Space Bayesian Optimization over Structured Inputs
Maus, Natalie, Jones, Haydn T, Moore, Juston S, Kusner, Matt J, Bradshaw, John, Gardner, Jacob R
Published in arXiv.org (22.02.2023)
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Published in arXiv.org (22.02.2023)
Paper
DIMERIC COMPOUNDS AND THEIR USE AS ANTI-VIRAL AGENTS
DEMAINE, DEREK A, SHANAHAN, STEPHEN E, JONES, HAYDN T, MACDONALD, SIMON J. F, MASON, ANDREW MCM
Year of Publication 27.09.2011
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Year of Publication 27.09.2011
Patent
DIMER COMPOUND AND USE THEREOF AS ANTIVIRAL AGENT
DEMAINE DEREK A, SHANAHAN STEPHEN E, JONES HAYDN T, MACDONALD SIMON J F, MASON ANDREW MCM
Year of Publication 24.12.2010
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Year of Publication 24.12.2010
Patent
Dimeric compounds and their use as anti-viral agents
Demaine, Derek A, Jones, Haydn T, MacDonald, Simon J. F, Mason, Andrew McM, Shanahan, Stephen E
Year of Publication 17.03.2009
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Year of Publication 17.03.2009
Patent
Dimeric compounds and their use as anti-viral agents
DEMAINE DEREK A, SHANAHAN STEPHEN E, JONES HAYDN T, MASON ANDREW MCM, MACDONALD SIMON J. F
Year of Publication 17.03.2009
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Year of Publication 17.03.2009
Patent
Dimeric compounds and their use as anti-viral agents
DEREK A. DEMAINE, ANDREW MCM MASON, HAYDN T JONES, STEPHEN E SHANAHAN, SIMON J F MACDONALD
Year of Publication 20.03.2008
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Year of Publication 20.03.2008
Patent
Dimeric compounds and their use as anti-viral agents
DEMAINE DEREK A.,JONES HAYDN T.,MACDONALD SIMON J. F.,MASON ANDREW MCM,SHANAHAN STEPHEN E
Year of Publication 31.10.2007
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Year of Publication 31.10.2007
Patent
DIMERIC COMPOUNDS AND THEIR USE AS ANTI-VIRAL AGENTS
MACDONALD SIMON J, DEMAINE DEREK A, MASON ANDREW M, SHANAHAN STEPHEN E, JONES HAYDN T
Year of Publication 27.09.2007
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Year of Publication 27.09.2007
Patent