Structure–activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal
Pearson, Max, Haslam, Carl, Fosberry, Andrew, Jones, Emma J., Reglinski, Mark, Reeves, Lucy, Edwards, Robert J., Lawrenson, Richard Ashley, Brown, Jonathan C., Mossakowska, Danuta, Pease, James Edward, Sriskandan, Shiranee
Published in Scientific reports (03.11.2023)
Published in Scientific reports (03.11.2023)
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GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Bamborough, Paul, Barnett, Heather A, Becher, Isabelle, Bird, Mark J, Chung, Chun-wa, Craggs, Peter D, Demont, Emmanuel H, Diallo, Hawa, Fallon, David J, Gordon, Laurie J, Grandi, Paola, Hobbs, Clare I, Hooper-Greenhill, Edward, Jones, Emma J, Law, Robert P, Le Gall, Armelle, Lugo, David, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Sheppard, Robert J, Watson, Allan J. B, Watson, Robert J
Published in ACS medicinal chemistry letters (09.06.2016)
Published in ACS medicinal chemistry letters (09.06.2016)
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Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
Preston, Alex, Atkinson, Stephen, Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D, Gordon, Laurie, Grandi, Paola, Gray, James R. J, Jones, Emma J, Lindon, Matthew, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Rianjongdee, Francesco, Rioja, Inmaculada, Seal, Jonathan, Taylor, Simon, Wall, Ian, Watson, Robert J, Woolven, James, Demont, Emmanuel H
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Development of an intracellular quantitative assay to measure compound binding kinetics
Lay, Charles S., Thomas, Daniel A., Evans, John P., Campbell, Matthew, McCombe, Kristopher, Phillipou, Alexander N., Gordon, Laurie J., Jones, Emma J., Riching, Kristin, Mahmood, Mahnoor, Messenger, Cassie, Carver, Charlotte E., Gatfield, Kelly M., Craggs, Peter D.
Published in Cell chemical biology (21.12.2023)
Published in Cell chemical biology (21.12.2023)
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Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors
Bamborough, Paul, Chung, Chun-wa, Furze, Rebecca C, Grandi, Paola, Michon, Anne-Marie, Sheppard, Robert J, Barnett, Heather, Diallo, Hawa, Dixon, David P, Douault, Clement, Jones, Emma J, Karamshi, Bhumika, Mitchell, Darren J, Prinjha, Rab K, Rau, Christina, Watson, Robert J, Werner, Thilo, Demont, Emmanuel H
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Development of an intracellular quantitative assay to measure compound binding kinetics
Lay, Charles S., Thomas, Daniel A., Evans, John P., Campbell, Matthew, McCombe, Kristopher, Phillipou, Alexander N., Gordon, Laurie J., Jones, Emma J., Riching, Kristin, Mahmood, Mahnoor, Messenger, Cassie, Carver, Charlotte E., Gatfield, Kelly M., Craggs, Peter D.
Published in Cell chemical biology (17.02.2022)
Published in Cell chemical biology (17.02.2022)
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Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
Demont, Emmanuel H., Chung, Chun-wa, Furze, Rebecca C., Grandi, Paola, Michon, Anne-Marie, Wellaway, Chris, Barrett, Nathalie, Bridges, Angela M., Craggs, Peter D., Diallo, Hawa, Dixon, David P., Douault, Clement, Emmons, Amanda J., Jones, Emma J., Karamshi, Bhumika V., Locke, Kelly, Mitchell, Darren J., Mouzon, Bernadette H., Prinjha, Rab K., Roberts, Andy D., Sheppard, Robert J., Watson, Robert J., Bamborough, Paul
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification
Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Bridges, Angela M, Craggs, Peter D, Dixon, David P, Francis, Peter, Furze, Rebecca C, Grandi, Paola, Jones, Emma J, Karamshi, Bhumika, Locke, Kelly, Lucas, Simon C. C, Michon, Anne-Marie, Mitchell, Darren J, Pogány, Peter, Prinjha, Rab K, Rau, Christina, Roa, Ana Maria, Roberts, Andrew D, Sheppard, Robert J, Watson, Robert J
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
Demont, Emmanuel H, Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D, Fallon, David, Gordon, Laurie J, Grandi, Paola, Hobbs, Clare I, Hussain, Jameed, Jones, Emma J, Le Gall, Armelle, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Roberts, Andy D, Sheppard, Robert J, Watson, Robert J
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions
Phillipou, Alexander N., Lay, Charles S., Carver, Charlotte E., Messenger, Cassie, Evans, John P., Lewis, Antonia J., Gordon, Laurie J., Mahmood, Mahnoor, Greenhough, Luke A., Sammon, Douglas, Cheng, Aaron T., Chakraborty, Syandan, Jones, Emma J., Lucas, Simon C.C., Gatfield, Kelly M., Brierley, David J., Craggs, Peter D.
Published in SLAS discovery (01.02.2020)
Published in SLAS discovery (01.02.2020)
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1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3
Christopher, John A., Atkinson, Francis L., Bax, Benjamin D., Brown, Murray J.B., Champigny, Aurélie C., Chuang, Tsu Tshen, Jones, Emma J., Mosley, Julie E., Musgrave, James R.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Discovery and Characterizatlion of Small Molecule Inhibitors of the BET Family Bromodomains
Chung, Chun-wa, Coste, Herve, White, Julia H., Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L., Delves, Chris, Magny, Sylvie M., Woodward, Robert, Hughes, Stephen A., Boursier, Eric V., Flynn, Helen, Bouillot, Anne M., Bamborough, Paul, Brusq, Jean-Marie G., Gellibert, Francoise J., Jones, Emma J., Riou, Alizon M., Homes, Paul, Martin, Sandrine L., Uings, Iain J., Toum, Jerome, Clement, Catherine A., Boullay, Anne-Benedicte, Grimley, Rachel L., Blande, Florence M., Prinjha, Rab K., Lee, Kevin, Kirilovsky, Jorge, Nicodeme, Edwige
Published in Journal of medicinal chemistry (09.06.2011)
Published in Journal of medicinal chemistry (09.06.2011)
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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains
Chung, Chun-wa, Coste, Hervé, White, Julia H, Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L, Delves, Chris, Magny, Sylvie M, Woodward, Robert, Hughes, Stephen A, Boursier, Eric V, Flynn, Helen, Bouillot, Anne M, Bamborough, Paul, Brusq, Jean-Marie G, Gellibert, Françoise J, Jones, Emma J, Riou, Alizon M, Homes, Paul, Martin, Sandrine L, Uings, Iain J, Toum, Jérôme, Clément, Catherine A, Boullay, Anne-Bénédicte, Grimley, Rachel L, Blandel, Florence M, Prinjha, Rab K, Lee, Kevin, Kirilovsky, Jorge, Nicodeme, Edwige
Published in Journal of medicinal chemistry (09.06.2011)
Published in Journal of medicinal chemistry (09.06.2011)
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Identification, Cloning, and Expression of a Functional Phenylalanyl-tRNA Synthetase (pheRS) from Staphylococcus aureus
Savopoulos, John W., Hibbs, Martin, Jones, Emma J., Mensah, Lucy, Richardson, Christine, Fosberry, Andrew, Downes, Rosalind, Fox, Simon G., Brown, James R., Jenkins, Owen
Published in Protein expression and purification (01.04.2001)
Published in Protein expression and purification (01.04.2001)
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