Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Published in Nature communications (11.12.2019)
Published in Nature communications (11.12.2019)
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
Syed, Aleem, Filandr, Frantisek, Patterson-Fortin, Jeffrey, Bacolla, Albino, Ravindranathan, Ramya, Zhou, Jia, McDonald, Drew T, Albuhluli, Mohammed E, Verway-Cohen, Amy, Newman, Joseph A, Tsai, Miaw-Sheue, Jones, Darin E, Schriemer, David C, D’Andrea, Alan D, Tainer, John A
Published in Nucleic acids research (13.10.2023)
Published in Nucleic acids research (13.10.2023)
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Climate-driven changes in the timing of spawning and the availability of walleye pollock ( Gadus chalcogrammus ) to assessment surveys in the Gulf of Alaska
Rogers, Lauren A, Monnahan, Cole C, Williams, Kresimir, Jones, Darin T, Dorn, Martin W
Published in ICES journal of marine science (30.01.2024)
Published in ICES journal of marine science (30.01.2024)
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Brosey, Chris A., Link, Todd M., Shen, Runze, Moiani, Davide, Burnett, Kathryn, Hura, Greg L., Jones, Darin E., Tainer, John A.
Published in Nature chemical biology (01.09.2024)
Published in Nature chemical biology (01.09.2024)
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Journal Article
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Published in Progress in biophysics and molecular biology (01.08.2021)
Published in Progress in biophysics and molecular biology (01.08.2021)
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Applying HT-SAXS to chemical ligand screening
Brosey, Chris A, Shen, Runze, Moiani, Davide, Jones, Darin E, Burnett, Kathryn, Hura, Greg L, Tainer, John A
Published in Methods in enzymology (01.01.2023)
Published in Methods in enzymology (01.01.2023)
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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
Nguyen, My T., Moiani, Davide, Ahmed, Zamal, Arvai, Andrew S., Namjoshi, Sarita, Shin, Dave S., Fedorov, Yuriy, Selvik, Edward J., Jones, Darin E., Pink, John, Yan, Yan, Laverty, Daniel J., Nagel, Zachary D., Tainer, John A., Gerson, Stanton L.
Published in Progress in biophysics and molecular biology (01.08.2021)
Published in Progress in biophysics and molecular biology (01.08.2021)
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Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Mery, David E, Compadre, Amanda J, Ordóñez, Paola E, Selvik, Edward J, Morocho, Vladimir, Contreras, Jorge, Malagón, Omar, Jones, Darin E, Breen, Philip J, Balick, Michael J, Gaudio, Flavio G, Guzman, Monica L, Compadre, Cesar M
Published in Molecules (Basel, Switzerland) (04.05.2022)
Published in Molecules (Basel, Switzerland) (04.05.2022)
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Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets
Franco, Francisco M., Jones, Darin E., Harris, Peter K.W., Han, Zhenfu, Wildman, Scott A., Jarvis, Cassie M., Janetka, James W.
Published in Bioorganic & medicinal chemistry (15.05.2015)
Published in Bioorganic & medicinal chemistry (15.05.2015)
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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Moiani, Davide, Link, Todd M, Brosey, Chris A, Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E, Tsutakawa, Susan E, Tainer, John A
Published in Methods in enzymology (2021)
Published in Methods in enzymology (2021)
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Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor
Howes, Timothy R.L., Sallmyr, Annahita, Brooks, Rhys, Greco, George E., Jones, Darin E., Matsumoto, Yoshihiro, Tomkinson, Alan E.
Published in DNA repair (01.12.2017)
Published in DNA repair (01.12.2017)
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Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
Ordóñez, Paola E, Mery, David E, Sharma, Krishan K, Nemu, Saumyadip, Reynolds, William F, Enriquez, Raul G, Burns, Darcy C, Malagón, Omar, Jones, Darin E, Guzman, Monica L, Compadre, Cesar M
Published in Molecules (Basel, Switzerland) (20.10.2020)
Published in Molecules (Basel, Switzerland) (20.10.2020)
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Comparison of model types for prediction of seafloor trawlability in the Gulf of Alaska by using multibeam sonar data
Stienessen, Sarah C, Rooper, Christopher N, Weber, Thomas C, Jones, Darin T, Pirtle, Jodi L, Wilson, Christopher D
Published in Fishery bulletin (Washington, D.C.) (01.04.2021)
Published in Fishery bulletin (Washington, D.C.) (01.04.2021)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
Shrum, Stephen A, Nukala, Ujwani, Shrimali, Shivangi, Pineda, Edith Nathalie, Krager, Kimberly J, Thakkar, Shraddha, Jones, Darin E, Pathak, Rupak, Breen, Philip J, Aykin-Burns, Nukhet, Compadre, Cesar M
Published in Antioxidants (01.11.2023)
Published in Antioxidants (01.11.2023)
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GRB2 enforces homology-directed repair initiation by MRE11
Ye, Zu, Xu, Shengfeng, Shi, Yin, Bacolla, Albino, Syed, Aleem, Moiani, Davide, Tsai, Chi-Lin, Shen, Qiang, Peng, Guang, Leonard, Paul G, Jones, Darin E, Wang, Bin, Tainer, John A, Ahmed, Zamal
Published in Science advances (01.08.2021)
Published in Science advances (01.08.2021)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Shrimali, Shivangi, Singh, Awantika, Manian, Rajeshkumar, Thakkar, Shraddha, Jones, Darin E., Aykin-Burns, Nukhet, Breen, Philip, Compadre, Cesar M.
Published in Journal of clinical and translational science (01.04.2023)
Published in Journal of clinical and translational science (01.04.2023)
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Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer
Han, Zhenfu, Harris, Peter K. W, Jones, Darin E, Chugani, Ryan, Kim, Tommy, Agarwal, Manjula, Shen, Wei, Wildman, Scott A, Janetka, James W
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Journal Article
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
Ordóñez, Paola E, Sharma, Krishan K, Bystrom, Laura M, Alas, Maria A, Enriquez, Raul G, Malagón, Omar, Jones, Darin E, Guzman, Monica L, Compadre, Cesar M
Published in Journal of natural products (Washington, D.C.) (22.04.2016)
Published in Journal of natural products (Washington, D.C.) (22.04.2016)
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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation
Arhancet, Graciela B., Walker, Daniel P., Metz, Sue, Fobian, Yvette M., Heasley, Steven E., Carter, Jeffrey S., Springer, John R., Jones, Darin E., Hayes, Michael J., Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Zweifel, Ben, Moore, William M., Masferrer, Jaime L., Vazquez, Michael L.
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
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Journal Article
Erratum to “Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor” [DNA Repair 60C (2017) 29–39]
Howes, Timothy R.L., Sallmyr, Annahita, Brooks, Rhys, Greco, George E., Jones, Darin E., Matsumoto, Yoshihiro, Tomkinson, Alan E.
Published in DNA repair (01.01.2018)
Published in DNA repair (01.01.2018)
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