Search Results - "Jonczyk, Jakub" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

by Panek, Dawid, Więckowska, Anna, Wichur, Tomasz, Bajda, Marek, Godyń, Justyna, Jończyk, Jakub, Mika, Kamil, Janockova, Jana, Soukup, Ondrej, Knez, Damijan, Korabecny, Jan, Gobec, Stanislav, Malawska, Barbara
Published in European journal of medicinal chemistry (05.01.2017)

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Journal Article

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

by Wichur, Tomasz, Więckowska, Anna, Więckowski, Krzysztof, Godyń, Justyna, Jończyk, Jakub, Valdivieso, Álvaro del Río, Panek, Dawid, Pasieka, Anna, Sabaté, Raimon, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara
Published in European journal of medicinal chemistry (01.02.2020)

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Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists

Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists

by Staszewski, Marek, Nelic, Dominik, Jończyk, Jakub, Dubiel, Mariam, Frank, Annika, Stark, Holger, Bajda, Marek, Jakubik, Jan, Walczyński, Krzysztof
Published in ACS chemical neuroscience (07.07.2021)

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Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

by Panek, Dawid, Więckowska, Anna, Jończyk, Jakub, Godyń, Justyna, Bajda, Marek, Wichur, Tomasz, Pasieka, Anna, Knez, Damijan, Pišlar, Anja, Korabecny, Jan, Soukup, Ondrej, Sepsova, Vendula, Sabaté, Raimon, Kos, Janko, Gobec, Stanislav, Malawska, Barbara
Published in ACS chemical neuroscience (16.05.2018)

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2‑(4-Fluorophenyl)‑1H‑benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA‑A Receptor-Positive Allosteric Modulators

2‑(4-Fluorophenyl)‑1H‑benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA‑A Receptor-Positive Allosteric Modulators

by Marcinkowska, Monika, Fajkis-Zajączkowska, Nikola, Szafrańska, Katarzyna, Jończyk, Jakub, Siwek, Agata, Mordyl, Barbara, Karcz, Tadeusz, Latacz, Gniewomir, Kolaczkowski, Marcin
Published in ACS chemical neuroscience (15.03.2023)

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Discovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters

Discovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters

by Pasieka, Anna, Panek, Dawid, Jończyk, Jakub, Godyń, Justyna, Szałaj, Natalia, Latacz, Gniewomir, Tabor, Julia, Mezeiova, Eva, Chantegreil, Fabien, Dias, José, Knez, Damijan, Lu, Junfeng, Pi, Rongbiao, Korabecny, Jan, Brazzolotto, Xavier, Gobec, Stanislav, Höfner, Georg, Wanner, Klaus, Więckowska, Anna, Malawska, Barbara
Published in European journal of medicinal chemistry (05.06.2021)

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Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment

Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment

by Czarnecka, Kamila, Chufarova, Nina, Halczuk, Krzysztof, Maciejewska, Karolina, Girek, Małgorzata, Skibiński, Robert, Jończyk, Jakub, Bajda, Marek, Kabziński, Jacek, Majsterek, Ireneusz, Szymański, Paweł
Published in European journal of medicinal chemistry (10.02.2018)

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Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease

Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease

by Bajda, Marek, Jończyk, Jakub, Malawska, Barbara, Czarnecka, Kamila, Girek, Małgorzata, Olszewska, Paulina, Sikora, Joanna, Mikiciuk-Olasik, Elżbieta, Skibiński, Robert, Gumieniczek, Anna, Szymański, Paweł
Published in Bioorganic & medicinal chemistry (01.09.2015)

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Search for multifunctional agents against Alzheimer’s disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives

Search for multifunctional agents against Alzheimer’s disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives

by Jończyk, Jakub, Lodarski, Krzysztof, Staszewski, Marek, Godyń, Justyna, Zaręba, Paula, Soukup, Ondrej, Janockova, Jana, Korabecny, Jan, Sałat, Kinga, Malikowska-Racia, Natalia, Hebda, Michalina, Szałaj, Natalia, Filipek, Barbara, Walczyński, Krzysztof, Malawska, Barbara, Bajda, Marek
Published in Bioorganic chemistry (01.09.2019)

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Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer’s disease treatment

Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer’s disease treatment

by Czarnecka, Kamila, Szymański, Paweł, Girek, Małgorzata, Mikiciuk-Olasik, Elżbieta, Skibiński, Robert, Kabziński, Jacek, Majsterek, Ireneusz, Malawska, Barbara, Jończyk, Jakub, Bajda, Marek
Published in Bioorganic chemistry (01.06.2017)

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Journal Article

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

by Zagórska, Agnieszka, Partyka, Anna, Bucki, Adam, Kołaczkowski, Marcin, Jastrzębska‐Więsek, Magdalena, Czopek, Anna, Siwek, Agata, Głuch‐Lutwin, Monika, Bednarski, Marek, Bajda, Marek, Jończyk, Jakub, Piska, Kamil, Koczurkiewicz, Paulina, Wesołowska, Anna, Pawłowski, Maciej
Published in Chemical biology & drug design (01.04.2019)

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Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

by Lee, Hyun Myung, Andrys, Rudolf, Jonczyk, Jakub, Kim, Kyuneun, Vishakantegowda, Avinash G., Malinak, David, Skarka, Adam, Schmidt, Monika, Vaskova, Michaela, Latka, Kamil, Bajda, Marek, Jung, Young-Sik, Malawska, Barbara, Musilek, Kamil
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2021)

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Therapeutic strategies for Alzheimer's disease in clinical trials

Therapeutic strategies for Alzheimer's disease in clinical trials

by Godyń, Justyna, Jończyk, Jakub, Panek, Dawid, Malawska, Barbara
Published in Pharmacological reports (01.02.2016)

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γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases

γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases

by Łątka, Kamil, Jończyk, Jakub, Bajda, Marek
Published in International journal of biological macromolecules (01.09.2020)

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Journal Article

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines

by Lodarski, Krzysztof, Jo czyk, Jakub, Guzior, Natalia, Bajda, Marek, G adysz, Joanna, Walczyk, Joanna, Jele, Ma gorzata, Morak-M odawska, Beata, Pluta, Krystian, Malawska, Barbara
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2015)

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Dual-Acting Diether Derivatives of Piperidine and Homopiperidine with Histamine H3 Receptor Antagonistic and Anticholinesterase Activity

Dual-Acting Diether Derivatives of Piperidine and Homopiperidine with Histamine H3 Receptor Antagonistic and Anticholinesterase Activity

by Bajda, Marek, Kuder, Kamil J., Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Więckowska, Anna, Ignasik, Michalina, Guzior, Natalia, Jończyk, Jakub, Malawska, Barbara
Published in Archiv der Pharmazie (Weinheim) (01.08.2012)

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Journal Article

Structure modeling of γ-aminobutyric acid transporters – Molecular basics of ligand selectivity

Structure modeling of γ-aminobutyric acid transporters – Molecular basics of ligand selectivity

by Łątka, Kamil, Jończyk, Jakub, Bajda, Marek
Published in International journal of biological macromolecules (01.09.2020)

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Journal Article

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

by Jończyk, Jakub, Malawska, Barbara, Bajda, Marek
Published in PloS one (05.10.2017)

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Journal Article

Inhibitors of SARS-CoV-2 Main Protease (Mpro) as Anti-Coronavirus Agents

Inhibitors of SARS-CoV-2 Main Protease (Mpro) as Anti-Coronavirus Agents

by Zagórska, Agnieszka, Czopek, Anna, Fryc, Monika, Jończyk, Jakub
Published in Biomolecules (Basel, Switzerland) (04.07.2024)

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Synthesis, In Vitro, and Computational Studies of PTP1B Phosphatase Inhibitors Based on Oxovanadium(IV) and Dioxovanadium(V) Complexes

Synthesis, In Vitro, and Computational Studies of PTP1B Phosphatase Inhibitors Based on Oxovanadium(IV) and Dioxovanadium(V) Complexes

by Kostrzewa, Tomasz, Jończyk, Jakub, Drzeżdżon, Joanna, Jacewicz, Dagmara, Górska-Ponikowska, Magdalena, Kołaczkowski, Marcin, Kuban-Jankowska, Alicja
Published in International journal of molecular sciences (24.06.2022)

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