Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Metal compounds for the treatment of parasitic diseases
Fricker, Simon P., Mosi, Renee M., Cameron, Beth R., Baird, Ian, Zhu, Youngbao, Anastassov, Virginia, Cox, Jennifer, Doyle, Patricia S., Hansell, Elizabeth, Lau, Gloria, Langille, Jonathan, Olsen, Micki, Qin, Ling, Skerlj, Renato, Wong, Rebecca S.Y., Santucci, Zefferino, McKerrow, James H.
Published in Journal of inorganic biochemistry (01.10.2008)
Published in Journal of inorganic biochemistry (01.10.2008)
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Facile Preparation of Hydrazones by the Treatment of Azides with Hydrazines Catalyzed by FeCl3·6H2O
Barrett, Ian C, Langille, Jonathan D, Kerr, Michael A
Published in Journal of organic chemistry (22.09.2000)
Published in Journal of organic chemistry (22.09.2000)
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Journal Article
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-(2s,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-y1)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
Thorarensen, Atli, Dowty, Martin E., Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M., Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I., Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M., Brown, Matthew F., Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities
Chekler, Eugene L. Piatnitski, Pellegrino, Jessica A., Lanz, Thomas A., Denny, R. Aldrin, Flick, Andrew C., Coe, Jotham, Langille, Jonathan, Basak, Arindrajit, Liu, Shenping, Stock, Ingrid A., Sahasrabudhe, Parag, Bonin, Paul D., Lee, Kevin, Pletcher, Mathew T., Jones, Lyn H.
Published in Chemistry & biology (17.12.2015)
Published in Chemistry & biology (17.12.2015)
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Improved Synthesis of a Macrocyclic Peptide-Like C5aR Antagonist for Intravenous Applications
Feng, Yiqing, Liang, Sidney, Langille, Jonathan, Pierce, Betsy S., Chung, Seungwon, Szeliga, Jan, Wilcox, Glenn, Simonds, Paul, Farley, Kathleen A., Li, Bryan, Garcia-Irizarry, Carmen, Jones, Peter, Lira, Ricardo
Published in Organic process research & development (19.10.2023)
Published in Organic process research & development (19.10.2023)
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Improved Synthesis of a Macrocyclic Peptide-Like C5aR Antagonist for Intravenous Applications
Feng, Yiqing, Liang, Sidney, Langille, Jonathan, Pierce, Betsy S., Chung, SeungWon, Szeliga, Jan, Wilcox, Glenn, Simonds, Paul, Farley, Kathleen A., Li, Bryan, Garcia-Irizarry, Carmen, Jones, Peter, Lira, Ricardo
Published in Organic process research & development (17.11.2023)
Published in Organic process research & development (17.11.2023)
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Cyclic Peptide C5aR1 Antagonist Design Using Solution Conformational Analysis Derived from Residual Dipolar Couplings
Farley, Kathleen A., Che, Ye, Lira, Ricardo, Jones, Peter, Papaioannou, Nikolaos, Hayward, Matthew, Flanagan, Mark E., Langille, Jonathan, Liang, Sidney, Pierce, Betsy S., Ciszewski, Gregory, Bonin, Paul, Vincent, Fabien, Ramsey, Simeon, Hepworth, David
Published in ACS medicinal chemistry letters (29.10.2024)
Published in ACS medicinal chemistry letters (29.10.2024)
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Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain
Denny, R. Aldrin, Flick, Andrew C, Coe, Jotham, Langille, Jonathan, Basak, Arindrajit, Liu, Shenping, Stock, Ingrid, Sahasrabudhe, Parag, Bonin, Paul, Hay, Duncan A, Brennan, Paul E, Pletcher, Mathew, Jones, Lyn H, Chekler, Eugene L. Piatnitski
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol
Sperry, Jeffrey B, Price Wiglesworth, Kristin E, Edmonds, Ian, Fiore, Phillip, Boyles, David C, Damon, David B, Dorow, Roberta L, Piatnitski Chekler, Eugene L, Langille, Jonathan, Coe, Jotham W
Published in Organic process research & development (19.12.2014)
Published in Organic process research & development (19.12.2014)
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Design of Substituted Imidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV‑1 Replication
Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Metz, Markus, Harwig, Curtis, Li, Tong-Shuang, Yang, Wen, Bogucki, David, Zhu, Yongbao, Langille, Jonathan, Veale, Duane, Ba, Tuya, Bey, Michael, Baird, Ian, Kaller, Alan, Krumpak, Maria, Leitch, David, Satori, Michael, Vocadlo, Krystyna, Guay, Danielle, Nan, Susan, Yee, Helen, Crawford, Jason, Chen, Gang, Wilson, Trevor, Carpenter, Bryon, Gauthier, David, MacFarland, Ron, Mosi, Renee, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Schols, Dominique
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Design of Substituted lmidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV-1 Replication
Skerlj, Renato, Bridge, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Metz, Markus, Harwig, Curtis, Li, Tong-Shuang, Yang, Wen, Bogucki, David, Zhu, Yongbao, Langille, Jonathan, Veale, Duane, Ba, Tuya, Bey, Michael, Baird, Ian, Kaller, Alan, Krumpak, Maria, Leitch, David, Satori, Michael, Vocadlo, Krystyna, Guay, Danielle, Nan, Susan, Yee, Helen, Crawford, Jason, Chen, Gang, Wilson, Trevor, Carpenter, Bryon, Gauthier, David, MacFarland, Ron, Mosi, Renee, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Schols, Dominique
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach
Metz, Markus, Bourque, Elyse, Labrecque, Jean, Danthi, Sanjay J, Langille, Jonathan, Harwig, Curtis, Yang, Wen, Darkes, Marilyn C, Lau, Gloria, Santucci, Zefferino, Bridger, Gary J, Schols, Dominique, Fricker, Simon P, Skerlj, Renato T
Published in Journal of the American Chemical Society (19.10.2011)
Published in Journal of the American Chemical Society (19.10.2011)
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Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model
Chowdhury, Sultan, Liu, Shifeng, Cadieux, Jay A., Hsieh, Tom, Chafeev, Mikhail, Sun, Shaoyi, Jia, Qi, Sun, Jianyu, Wood, Mark, Langille, Jonathan, Sviridov, Serguei, Fu, Jianmin, Zhang, Zaihui, Chui, Ray, Wang, Audrey, Cheng, Xing, Zhong, Jing, Hossain, Sazzad, Khakh, Kuldip, Rajlic, Ivana, Verschoof, Henry, Kwan, Rainbow, Young, Wendy
Published in Medicinal chemistry research (01.04.2013)
Published in Medicinal chemistry research (01.04.2013)
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Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Langille, Jonathan, Harwig, Curtis, Veale, Duane, Yang, Wen, Li, Tongshong, Zhu, Yongbao, Bey, Michael, Baird, Ian, Sartori, Michael, Metz, Markus, Mosi, Renee, Nelson, Kim, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Mac Farland, Ron, Huskens, Dana, Schols, Dominique
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, Langille, Jonathan, Fluri, Maria Di, Bogucki, David, Yang, Wen, Li, Tongshuang, Wang, Letian, Nan, Susan, Baird, Ian, Metz, Markus, Darkes, Marilyn, Labrecque, Jean, Lau, Gloria, Fricker, Simon, Huskens, Dana, Schols, Dominique
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication
Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Danthi, Sanjay, Langille, Jonathan, Harwig, Curtis, Veale, Duane, Carpenter, Bryon, Ba, Tuya, Bey, Michael, Baird, Ian, Wilson, Trevor, Metz, Markus, MacFarland, Ron, Mosi, Renee, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Huskens, Dana, Schols, Dominique
Published in ACS medicinal chemistry letters (08.03.2012)
Published in ACS medicinal chemistry letters (08.03.2012)
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Erratum to “Metal compounds for the treatment of parasitic diseases” [J. Inorg. Biochem. 102 (2008) 1839–1845]
Fricker, Simon P., Mosi, Renee M., Cameron, Beth R., Baird, Ian, Zhu, Youngbao, Anastassov, Virginia, Cox, Jennifer, Doyle, Patricia S., Hansell, Elizabeth, Lau, Gloria, Langille, Jonathan, Olsen, Micki, Qin, Ling, Skerlj, Renato, Wong, Rebecca S.Y., Santucci, Zefferino, McKerrow, James H.
Published in Journal of inorganic biochemistry (01.05.2009)
Published in Journal of inorganic biochemistry (01.05.2009)
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SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS
SUN SHAOYI, JEAN-JACQUES CADIEUX, SUN JIANYU, WOOD MARK, SIMON J GAUTHIER, LAUREN FRASER, QI JIA, SULTAN CHOWDHURY, CHAKKA NAGASREE, ALLA ZENOVA, FU JIANMING, SHIFENG LIU, AMY FRANCES DOUGLAS, SVIRIDOV SERGUEI, CHAFEEV MIKHAIL, ZORAN CIKOJEVIC, JONATHAN LANGILLE, HSIEH TOM
Year of Publication 19.01.2015
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Year of Publication 19.01.2015
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