Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
Wang, Shan, Rhijn, Jon-Ruben van, Akkouh, Ibrahim, Kogo, Naoki, Maas, Nadine, Bleeck, Anna, Ortiz, Irene Santisteban, Lewerissa, Elly, Wu, Ka Man, Schoenmaker, Chantal, Djurovic, Srdjan, van Bokhoven, Hans, Kleefstra, Tjitske, Nadif Kasri, Nael, Schubert, Dirk
Published in Cell reports (Cambridge) (03.05.2022)
Published in Cell reports (Cambridge) (03.05.2022)
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Journal Article
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling
Frega, Monica, Linda, Katrin, Keller, Jason M., Gümüş-Akay, Güvem, Mossink, Britt, van Rhijn, Jon-Ruben, Negwer, Moritz, Klein Gunnewiek, Teun, Foreman, Katharina, Kompier, Nine, Schoenmaker, Chantal, van den Akker, Willem, van der Werf, Ilse, Oudakker, Astrid, Zhou, Huiqing, Kleefstra, Tjitske, Schubert, Dirk, van Bokhoven, Hans, Nadif Kasri, Nael
Published in Nature communications (30.10.2019)
Published in Nature communications (30.10.2019)
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Journal Article
Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks
Mossink, Britt, van Rhijn, Jon-Ruben, Wang, Shan, Linda, Katrin, Vitale, Maria R., Zöller, Johanna E. M., van Hugte, Eline J. H., Bak, Jitske, Verboven, Anouk H. A., Selten, Martijn, Negwer, Moritz, Latour, Brooke L., van der Werf, Ilse, Keller, Jason M., Klein Gunnewiek, Teun M., Schoenmaker, Chantal, Oudakker, Astrid, Anania, Alessia, Jansen, Sophie, Lesch, Klaus-Peter, Frega, Monica, van Bokhoven, Hans, Schubert, Dirk, Nadif Kasri, Nael
Published in Molecular psychiatry (01.01.2022)
Published in Molecular psychiatry (01.01.2022)
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Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays
Frega, Monica, van Gestel, Sebastianus H C, Linda, Katrin, van der Raadt, Jori, Keller, Jason, Van Rhijn, Jon-Ruben, Schubert, Dirk, Albers, Cornelis A, Nadif Kasri, Nael
Published in Journal of visualized experiments (08.01.2017)
Published in Journal of visualized experiments (08.01.2017)
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Systematic review and meta-analysis of the effect of bone marrow-derived cell therapies on hind limb perfusion
van Rhijn-Brouwer, Femke Christina Ching-Chuan, Wever, Kimberley Elaine, Kiffen, Romy, van Rhijn, Jon-Ruben, Gremmels, Hendrik, Fledderus, Joost Ougust, Vernooij, Robin Wilhelmus Maria, Verhaar, Marianne Christina
Published in Disease models & mechanisms (01.05.2024)
Published in Disease models & mechanisms (01.05.2024)
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Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons
van Rhijn, Jon-Ruben, Shi, Yan, Bormann, Maren, Mossink, Britt, Frega, Monica, Recaioglu, Hatice, Hakobjan, Marina, Klein Gunnewiek, Teun, Schoenmaker, Chantal, Palmer, Elizabeth, Faivre, Laurence, Kittel-Schneider, Sarah, Schubert, Dirk, Brunner, Han, Franke, Barbara, Nadif Kasri, Nael
Published in Neurobiology of disease (01.02.2022)
Published in Neurobiology of disease (01.02.2022)
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Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model
Vlasblom, Ronald, van Thiel, Jory, Bittenbinder, Matyas A., van Rhijn, Jon-Ruben, Drost, Rinske, Muis, Lotte, Slagboom, Julien, Salvatori, Daniela, Kool, Jeroen, Veldman, Robert Jan
Published in Toxicon (Oxford) (01.03.2024)
Published in Toxicon (Oxford) (01.03.2024)
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A human in vitro neuronal model for studying homeostatic plasticity at the network level
Yuan, Xiuming, Puvogel, Sofía, van Rhijn, Jon-Ruben, Ciptasari, Ummi, Esteve-Codina, Anna, Meijer, Mandy, Rouschop, Simon, van Hugte, Eline J.H., Oudakker, Astrid, Schoenmaker, Chantal, Frega, Monica, Schubert, Dirk, Franke, Barbara, Nadif Kasri, Nael
Published in Stem cell reports (14.11.2023)
Published in Stem cell reports (14.11.2023)
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Journal Article
F12AGGRESSION IN A DISH: A HUMAN MODEL FOR BRUNNER SYNDROME REVEALS INCREASED NEURONAL NETWORK ACTIVITY OF DOPAMINERGIC NEURONS
Shi, Yan, van Rhijn, Jon-Ruben, Bormann, Maren, Mossink, Britt, Frega, Monica, Hakobjan, Marina, Kittel-Schneider, Sarah, Keller, Jason, Schubert, Dirk, Brunner, Han, Franke, Barbara, Kasri, Nael Nadif
Published in European neuropsychopharmacology (2019)
Published in European neuropsychopharmacology (2019)
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Journal Article
Neurons derived from induced pluripotent stem cells on microelectrode arrays: a human model for neurodevelopmental disorders
Frega, Monica, Linda, Katrin, Mossink, Britt, Van Rhijn, Jon-Ruben, Keller, Jason, Van Gestel, Sebastian, Schubert, Dirk, Nadif Kasri, Nael
Published in Frontiers in cellular neuroscience (2018)
Published in Frontiers in cellular neuroscience (2018)
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Journal Article
Cell-type specific contribution to neuronal network (dys)function in neurodevelopmental disorders
Mossink, Britt, Frega, Monica, Van Rhijn, Jon-Ruben, Linda, Katrin, Schoenmaker, Chantal, Keller, Jason, Janssen, Sophie, Nadif Kasri, Nael, Schubert, Dirk
Published in Frontiers in cellular neuroscience (2018)
Published in Frontiers in cellular neuroscience (2018)
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Journal Article
Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays
Frega, Monica, van Gestel, Sebastianus H. C., Linda, Katrin, van der Raadt, Jori, Keller, Jason, Van Rhijn, Jon-Ruben, Schubert, Dirk, Albers, Cornelis A., Nadif Kasri, Nael
Published in Journal of visualized experiments (08.01.2017)
Published in Journal of visualized experiments (08.01.2017)
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Journal Article
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway
Wang, Shan, Jon-Ruben Van Rhijn, Akkouh, Ibrahim A, Kogo, Naoki, Maas, Nadine, Bleeck, Anna, Irene Santisteban Ortiz, Lewerissa, Elly, Wu, Ka Man, Schoenmaker, Chantal, Djurovic, Srdjan, Hans Van Bokhoven, Kleefstra, Tjitske, Kasri, Nael Nadif, Schubert, Dirk
Published in bioRxiv (25.09.2021)
Published in bioRxiv (25.09.2021)
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Paper
Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity
Shi, Yan, Jon-Ruben Van Rhijn, Bormann, Maren, Mossink, Britt, Frega, Monica, Recaioglu, Hatice, Hakobjan, Marina, Teun Klein Gunnewiek, Schoenmaker, Chantal, Palmer, Elizabeth, Faivre, Laurence, Kittel-Schneider, Sarah, Schubert, Dirk, Brunner, Han, Franke, Barbara, Kasri, Nael Nadif
Published in bioRxiv (29.10.2020)
Published in bioRxiv (29.10.2020)
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Paper
Brunner syndrome associated MAOA dysfunction in human iPSC derived dopaminergic neurons results in dysregulated NMDAR expression and increased network activity
Shi, Yan, Jon-Ruben Van Rhijn, Bormann, Maren, Mossink, Britt, Frega, Monica, Hakobjan, Marina, Kittel-Schneider, Sarah, Schubert, Dirk, Brunner, Han, Franke, Barbara, Kasri, Nael Nadif
Published in bioRxiv (21.08.2019)
Published in bioRxiv (21.08.2019)
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