Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma
Cloughesy, Timothy F, Landolfi, Joseph, Hogan, Daniel J, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Elder, J Bradley, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh Leia, Piccioni, David, Walbert, Tobias, Chu, Alice, Das, Asha, Diago, Oscar R, Gammon, Dawn, Gruber, Harry E, Hanna, Michelle, Jolly, Douglas J, Kasahara, Noriyuki, McCarthy, David, Mitchell, Leah, Ostertag, Derek, Robbins, Joan M, Rodriguez-Aguirre, Maria, Vogelbaum, Michael A
Published in Science translational medicine (01.06.2016)
Published in Science translational medicine (01.06.2016)
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Retroviral Replicating Vector Toca 511 ( Vocimagene Amiretrorepvec ) for Prodrug Activator Gene Therapy of Lung Cancer
Kushiya, Hiroki, Hiraoka, Kei, Suzuki, Tomohiro, Inoko, Kazuho, Inagaki, Akihito, Niwa, Hiroki, Sasaki, Katsunori, Nakamura, Toru, Tsuchikawa, Takahiro, Shichinohe, Toshiaki, Jolly, Douglas J, Kasahara, Noriyuki, Hirano, Satoshi
Published in Cancers (25.11.2022)
Published in Cancers (25.11.2022)
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Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity
Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T, Mitchell, Leah A, Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A, Ostertag, Derek, Robbins, Joan M, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
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Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model
Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M
Published in Human gene therapy (01.02.2015)
Published in Human gene therapy (01.02.2015)
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Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer
Inoko, Kazuho, Hiraoka, Kei, Inagaki, Akihito, Takahashi, Mizuna, Kushibiki, Toshihiro, Hontani, Koji, Takano, Hironobu, Sato, Shoki, Takeuchi, Shintaro, Nakamura, Toru, Tsuchikawa, Takahiro, Shichinohe, Toshiaki, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki, Hirano, Satoshi
Published in Cancer gene therapy (01.08.2018)
Published in Cancer gene therapy (01.08.2018)
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Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity
Lin, Amy H, Burrascano, Cindy, Pettersson, Par L, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J
Published in Journal of virology (01.09.2014)
Published in Journal of virology (01.09.2014)
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Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro
Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.
Published in Molecular therapy. Nucleic acids (17.03.2017)
Published in Molecular therapy. Nucleic acids (17.03.2017)
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Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types
Twitty, Chris G, Diago, Oscar R, Hogan, Daniel J, Burrascano, Cindy, Ibanez, Carlos E, Jolly, Douglas J, Ostertag, Derek
Published in Human gene therapy. Part B. Methods (01.02.2016)
Published in Human gene therapy. Part B. Methods (01.02.2016)
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A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy. Oncolytics (30.03.2018)
Published in Molecular therapy. Oncolytics (30.03.2018)
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Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion
Powell, Jerry S., Ragni, Margaret V., White, Gilbert C., Lusher, Jeanne M., Hillman-Wiseman, Carol, Moon, Tom E., Cole, Veronica, Ramanathan-Girish, Sandhya, Roehl, Holger, Sajjadi, Nancy, Jolly, Douglas J., Hurst, Deborah
Published in Blood (15.09.2003)
Published in Blood (15.09.2003)
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MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response
Lin, Amy H, Timberlake, Nina, Logg, Christopher R, Liu, Yanzheng, Kamijima, Shuichi, Diago, Oscar, Wong, Kenneth, Gammon, Dawn K, Ostertag, Derek, Hacke, Katrin, Yang, Emily C, Gruber, Harry, Kasahara, Noriyuki, Jolly, Douglas J
Published in Human gene therapy (01.08.2014)
Published in Human gene therapy (01.08.2014)
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Journal Article
Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC
Cloughesy, Timothy F, Landolfi, Joseph, Vogelbaum, Michael A, Ostertag, Derek, Elder, James B, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh, Piccioni, David, Accomando, William, Diago, Oscar R, Hogan, Daniel J, Gammon, Dawn, Kasahara, Noriyuki, Kheoh, Thian, Jolly, Douglas J, Gruber, Harry E, Das, Asha, Walbert, Tobias
Published in Neuro-oncology (Charlottesville, Va.) (03.09.2018)
Published in Neuro-oncology (Charlottesville, Va.) (03.09.2018)
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Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
Mitchell, Leah A, Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
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VSV-G Pseudotyped Lentiviral Vector Particles Produced in Human Cells Are Inactivated by Human Serum
DePolo, Nicholas J., Reed, Joyce D., Sheridan, Philip L., Townsend, Kay, Sauter, Sybille L., Jolly, Douglas J., Dubensky, Thomas W.
Published in Molecular therapy (01.09.2000)
Published in Molecular therapy (01.09.2000)
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Therapeutic activity of retroviral replicating vector-mediated gene therapy in combination with anti-PD-1 antibody in a murine pancreatic cancer model
Niwa, Hiroki, Nakamura, Toru, Kushiya, Hiroki, Kuraya, Tomotaka, Inoko, Kazuho, Inagaki, Akihito, Suzuki, Tomohiro, Sasaki, Katsunori, Tsuchikawa, Takahiro, Hiraoka, Kei, Shichinohe, Toshiaki, Hatanaka, Yutaka, Jolly, Douglas J., Kasahara, Noriyuki, Hirano, Satoshi
Published in Cancer gene therapy (01.09.2024)
Published in Cancer gene therapy (01.09.2024)
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Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients
Hogan, Daniel J, Zhu, Jay-Jiguang, Diago, Oscar R, Gammon, Dawn, Haghighi, Ali, Lu, Guangrong, Das, Asha, Gruber, Harry E, Jolly, Douglas J, Ostertag, Derek
Published in Clinical cancer research (01.10.2018)
Published in Clinical cancer research (01.10.2018)
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Journal Article
Molecular and Immunologic Signatures are Related to Clinical Benefit from Treatment with Vocimagene Amiretrorepvec (Toca 511) and 5-Fluorocytosine (Toca FC) in Patients with Glioma
Accomando, William P, Rao, Aliz R, Hogan, Daniel J, Newman, Aaron M, Nakao, Aki, Alizadeh, Ash A, Diehn, Maximilian, Diago, Oscar R, Gammon, Dawn, Haghighi, Ali, Gruber, Harry E, Jolly, Douglas J, Ostertag, Derek
Published in Clinical cancer research (01.12.2020)
Published in Clinical cancer research (01.12.2020)
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Journal Article
Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression
Perez, Omar D, Logg, Christopher R, Hiraoka, Kei, Diago, Oscar, Burnett, Ryan, Inagaki, Akihito, Jolson, Dawn, Amundson, Karin, Buckley, Taylor, Lohse, Dan, Lin, Amy, Burrascano, Cindy, Ibanez, Carlos, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J
Published in Molecular therapy (01.09.2012)
Published in Molecular therapy (01.09.2012)
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Journal Article
Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models
Hofacre, Andrew, Yagiz, Kader, Mendoza, Daniel, Lopez Espinoza, Fernando, Munday, Anthony W, Burrascano, Cynthia, Singer, Oded, Gruber, Harry E, Jolly, Douglas J, Lin, Amy H
Published in Human gene therapy (01.04.2018)
Published in Human gene therapy (01.04.2018)
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