In Vivo Visualization of β-Cells by Targeting of GPR44
Eriksson, Olof, Johnström, Peter, Cselenyi, Zsolt, Jahan, Mahabuba, Selvaraju, Ram K, Jensen-Waern, Marianne, Takano, Akihiro, Sörhede Winzell, Maria, Halldin, Christer, Skrtic, Stanko, Korsgren, Olle
Published in Diabetes (New York, N.Y.) (01.02.2018)
Published in Diabetes (New York, N.Y.) (01.02.2018)
Get full text
Journal Article
Preclinical comparison of the blood brain barrier (BBB) permeability of osimertinib (AZD9291) with other irreversible next generation EGFR TKIs
Colclough, N, Ballard, P.G, Barton, P, Chen, K, Cross, D.A.E, Finlay, M.R.V, Han, L, Janefeldt, A, Johnström, P, Ward, R.A, Wrigley, G.L, Yan, Y, Yates, J.W.T, Zhang, D, Zhang, Z
Published in EUROPEAN JOURNAL OF CANCER (01.12.2016)
Published in EUROPEAN JOURNAL OF CANCER (01.12.2016)
Get full text
Journal Article
Conference Proceeding
Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676
Varnäs, Katarina, Juréus, Anders, Johnström, Peter, Ahlgren, Charlotte, Schött, Pär, Schou, Magnus, Gruber, Susanne, Jerning, Eva, Malmborg, Jonas, Halldin, Christer, Afzelius, Lovisa, Farde, Lars
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Get full text
Journal Article
Toward molecular imaging of the free fatty acid receptor 1
Hellström-Lindahl, Ewa, Åberg, Ola, Ericsson, Cecilia, O’Mahony, Gavin, Johnström, Peter, Skrtic, Stanko, Eriksson, Olof
Published in Acta diabetologica (01.07.2017)
Published in Acta diabetologica (01.07.2017)
Get full text
Journal Article
Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography
RUDD, J. H. F, WARBURTON, E. A, PICKARD, J. D, WEISSBERG, P. L, FRYER, T. D, JONES, H. A, CLARK, J. C, ANTOUN, N, JOHNSTRÖM, P, DAVENPORT, A. P, KIRKPATRICK, P. J, ARCH, B. N
Published in Circulation (New York, N.Y.) (11.06.2002)
Published in Circulation (New York, N.Y.) (11.06.2002)
Get full text
Journal Article
Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity
Ballard, Peter, Yates, James W T, Yang, Zhenfan, Kim, Dong-Wan, Yang, James Chih-Hsin, Cantarini, Mireille, Pickup, Kathryn, Jordan, Angela, Hickey, Mike, Grist, Matthew, Box, Matthew, Johnström, Peter, Varnäs, Katarina, Malmquist, Jonas, Thress, Kenneth S, Jänne, Pasi A, Cross, Darren
Published in Clinical cancer research (15.10.2016)
Published in Clinical cancer research (15.10.2016)
Get full text
Journal Article
Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs
Colclough, Nicola, Chen, Kan, Johnström, Peter, Strittmatter, Nicole, Yan, Yumei, Wrigley, Gail L, Schou, Magnus, Goodwin, Richard, Varnäs, Katarina, Adua, Sally J, Zhao, Minghui, Nguyen, Don X, Maglennon, Gareth, Barton, Peter, Atkinson, James, Zhang, Lin, Janefeldt, Annika, Wilson, Joanne, Smith, Aaron, Takano, Akihiro, Arakawa, Ryosuke, Kondrashov, Mikhail, Malmquist, Jonas, Revunov, Evgeny, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Windhorst, Albert D, Karp, Natasha A, Finlay, M Raymond V, Ward, Richard A, Yates, James W T, Smith, Paul D, Farde, Lars, Cheng, Zack, Cross, Darren A E
Published in Clinical cancer research (01.01.2021)
Published in Clinical cancer research (01.01.2021)
Get full text
Journal Article
Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
Zeng, Qingbei, Wang, Jiabing, Cheng, Ziqiang, Chen, Kan, Johnström, Peter, Varnäs, Katarina, Li, David Yunzhi, Yang, Zhen Fan, Zhang, Xiaolin
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
Get full text
Journal Article
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease
Jucaite, Aurelija, Svenningsson, Per, Rinne, Juha O, Cselényi, Zsolt, Varnäs, Katarina, Johnström, Peter, Amini, Nahid, Kirjavainen, Anna, Helin, Semi, Minkwitz, Margaret, Kugler, Alan R, Posener, Joel A, Budd, Samantha, Halldin, Christer, Varrone, Andrea, Farde, Lars
Published in Brain (London, England : 1878) (01.09.2015)
Published in Brain (London, England : 1878) (01.09.2015)
Get full text
Journal Article
Comparative in vivo biodistribution and dosimetry in non-human primate of the fibroblast activation protein radiotracers [68Ga]Ga-FAPI-04, [68Ga]Ga-FAPI-46 and [18F]FAPI-74
Tran, Thuy, Bolin, Martin, Dahl, Kenneth, Johnstrom, Peter, Mitran, Bogdan, Siikanen, Jonathan, Schou, Magnus
Published in NUCLEAR MEDICINE AND BIOLOGY (01.05.2022)
Published in NUCLEAR MEDICINE AND BIOLOGY (01.05.2022)
Get full text
Journal Article
Conference Proceeding
Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [11C]PBR28 and Machine Learning Analysis
Jucaite, Aurelija, Cselényi, Zsolt, Kreisl, William C., Rabiner, Eugenii A., Varrone, Andrea, Carson, Richard E., Rinne, Juha O., Savage, Alicia, Schou, Magnus, Johnström, Peter, Svenningsson, Per, Rascol, Olivier, Meissner, Wassilios G., Barone, Paolo, Seppi, Klaus, Kaufmann, Horacio, Wenning, Gregor K., Poewe, Werner, Farde, Lars
Published in Movement disorders (01.01.2022)
Published in Movement disorders (01.01.2022)
Get full text
Journal Article
Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study
Jucaite, Aurelija, Stenkrona, Per, Cselényi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnäs, Katarina, Savage, Alicia, Varrone, Andrea, Johnström, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Pilla Reddy, Venkatesh, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S, Pass, Martin, Farde, Lars
Published in Neuro-oncology (Charlottesville, Va.) (12.04.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.04.2021)
Get full text
Journal Article
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1
Staniszewska, Anna D, Pilger, Domenic, Gill, Sonja J, Jamal, Kunzah, Bohin, Natacha, Guzzetti, Sofia, Gordon, Jacob, Hamm, Gregory, Mundin, Gill, Illuzzi, Giuditta, Pike, Andy, McWilliams, Lisa, Maglennon, Gareth, Rose, Jonathan, Hawthorne, Glen, Cortes Gonzalez, Miguel, Halldin, Christer, Johnström, Peter, Schou, Magnus, Critchlow, Susan E, Fawell, Stephen, Johannes, Jeffrey W, Leo, Elisabetta, Davies, Barry R, Cosulich, Sabina, Sarkaria, Jann N, O'Connor, Mark J, Hamerlik, Petra
Published in Clinical cancer research (01.04.2024)
Published in Clinical cancer research (01.04.2024)
Get full text
Journal Article
Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery
Colclough, Nicola, Chen, Kan, Johnström, Peter, Fridén, Markus, McGinnity, Dermot F.
Published in Drug discovery today (01.05.2019)
Published in Drug discovery today (01.05.2019)
Get full text
Journal Article
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
Durant, Stephen T, Zheng, Li, Wang, Yingchun, Chen, Kan, Zhang, Lingli, Zhang, Tianwei, Yang, Zhenfan, Riches, Lucy, Trinidad, Antonio G, Fok, Jacqueline H L, Hunt, Tom, Pike, Kurt G, Wilson, Joanne, Smith, Aaron, Colclough, Nicola, Reddy, Venkatesh Pilla, Sykes, Andrew, Janefeldt, Annika, Johnström, Peter, Varnäs, Katarina, Takano, Akihiro, Ling, Stephanie, Orme, Jonathan, Stott, Jonathan, Roberts, Caroline, Barrett, Ian, Jones, Gemma, Roudier, Martine, Pierce, Andrew, Allen, Jasmine, Kahn, Jenna, Sule, Amrita, Karlin, Jeremy, Cronin, Anna, Chapman, Melissa, Valerie, Kristoffer, Illingworth, Ruth, Pass, Martin
Published in Science advances (01.06.2018)
Published in Science advances (01.06.2018)
Get full text
Journal Article
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390
Pike, Kurt G., Hunt, Thomas A., Barlaam, Bernard, Benstead, David, Cadogan, Elaine, Chen, Kan, Cook, Calum R., Colclough, Nicola, Deng, Chao, Durant, Stephen T., Eatherton, Andrew, Goldberg, Kristin, Johnström, Peter, Liu, Libin, Liu, Zhaoqun, Nissink, J. Willem M., Pang, Chengling, Pass, Martin, Robb, Graeme R., Roberts, Caroline, Schou, Magnus, Steward, Oliver, Sykes, Andy, Yan, Yumei, Zhai, Baochang, Zheng, Li
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
Get full text
Journal Article
Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo
Varnäs, Katarina, Finnema, Sjoerd J., Johnström, Peter, Arakawa, Ryosuke, Halldin, Christer, Eriksson, Lars I., Farde, Lars
Published in British journal of anaesthesia : BJA (01.01.2021)
Published in British journal of anaesthesia : BJA (01.01.2021)
Get full text
Journal Article
The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans
Varnäs, Katarina, Cselényi, Zsolt, Arakawa, Ryosuke, Nag, Sangram, Stepanov, Vladimir, Moein, Mohammad Mahdi, Johnström, Peter, Kingston, Lee, Elmore, Charles S., Halldin, Christer, Farde, Lars
Published in Neuropharmacology (01.01.2020)
Published in Neuropharmacology (01.01.2020)
Get full text
Journal Article