Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine
Salvatore, Christopher A, Hershey, James C, Corcoran, Halea A, Fay, John F, Johnston, Victor K, Moore, Eric L, Mosser, Scott D, Burgey, Christopher S, Paone, Daniel V, Shaw, Anthony W, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M, Koblan, Kenneth S, Kane, Stefanie A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)
Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase
Dhanak, Dashyant, Duffy, Kevin J., Johnston, Victor K., Lin-Goerke, Juili, Darcy, Michael, Shaw, Antony N., Gu, Baohua, Silverman, Carol, Gates, Adam T., Nonnemacher, Michael R., Earnshaw, David L., Casper, David J., Kaura, Arun, Baker, Audrey, Greenwood, Cathy, Gutshall, Lester L., Maley, Derrick, DelVecchio, Alfred, Macarron, Ricardo, Hofmann, Glenn A., Alnoah, Zaid, Cheng, Hung-Yuan, Chan, George, Khandekar, Sanjay, Keenan, Richard M., Sarisky, Robert T.
Published in The Journal of biological chemistry (11.10.2002)
Published in The Journal of biological chemistry (11.10.2002)
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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor
NGUYEN, Tammy T, GATES, Adam T, GUTSHALL, Lester L, JOHNSTON, Victor K, BAOHUA GU, DUFFY, Kevin J, SARISKY, Robert T
Published in Antimicrobial Agents and Chemotherapy (01.11.2003)
Published in Antimicrobial Agents and Chemotherapy (01.11.2003)
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Arresting Initiation of Hepatitis C Virus RNA Synthesis Using Heterocyclic Derivatives
Gu, Baohua, Johnston, Victor K., Gutshall, Lester L., Nguyen, Tammy T., Gontarek, Richard R., Darcy, Michael G., Tedesco, Rosanna, Dhanak, Dashyant, Duffy, Kevin J., Kao, C. Cheng, Sarisky, Robert T.
Published in The Journal of biological chemistry (09.05.2003)
Published in The Journal of biological chemistry (09.05.2003)
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An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
Evans, Karen A., Chai, Deping, Graybill, Todd L., Burton, George, Sarisky, Robert T., Lin-Goerke, Juili, Johnston, Victor K., Rivero, Ralph A.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase
Tedesco, Rosanna, Shaw, Antony N, Bambal, Ramesh, Chai, Deping, Concha, Nestor O, Darcy, Michael G, Dhanak, Dashyant, Fitch, Duke M, Gates, Adam, Gerhardt, Warren G, Halegoua, Dina L, Han, Chao, Hofmann, Glenn A, Johnston, Victor K, Kaura, Arun C, Liu, Nannan, Keenan, Richard M, Lin-Goerke, Juili, Sarisky, Robert T, Wiggall, Kenneth J, Zimmerman, Michael N, Duffy, Kevin J
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase
Shaw, Antony N., Tedesco, Rosanna, Bambal, Ramesh, Chai, Deping, Concha, Nestor O., Darcy, Michael G., Dhanak, Dashyant, Duffy, Kevin J., Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Liu, Nannan, Sarisky, Robert T., Wiggall, Kenneth J., Zimmerman, Michael N.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors
Tedesco, Rosanna, Chai, Deping, Darcy, Michael G., Dhanak, Dashyant, Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Sarisky, Robert T., Shaw, Antony N., Valko, Klara L., Wiggall, Kenneth J., Zimmerman, Michael N., Duffy, Kevin J.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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The discovery of highly potent CGRP receptor antagonists
Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Bruno, Joseph G., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Salvatore, Christopher A., Theberge, Cory R., Blair Zartman, C., Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Potent benzimidazolone-based CGRP receptor antagonists
THEBERGE, Cory R, BEDNAR, Rodney A, WILLIAMS, Theresa M, ZARTMAN, C. Blair, ZHANG, Xu-Fang, GRAHAM, Samuel L, VACCA, Joseph P, BELL, Ian M, CORCORAN, Halea A, FAY, John F, HERSHEY, James C, JOHNSTON, Victor K, KANE, Stefanie A, MOSSER, Scott, SALVATORE, Christopher A
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Corcoran, Halea A., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Hershey, James C., Miller-Stein, Cynthia M., Moore, Eric L., Mosser, Scott D., Roller, Shane A., Salvatore, Christopher A., Theberge, Cory R., Wong, Bradley K., Blair Zartman, C., Kane, Stefanie A., Williams, Theresa M., Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase
Ranjith-Kumar, C.T, Santos, Jan Lee, Gutshall, Lester L, Johnston, Victor K, Lin-Goerke, Juili, Kim, Min-Ju, Porter, David J, Maley, Derrick, Greenwood, Cathy, Earnshaw, David L, Baker, Audrey, Gu, Baohua, Silverman, Carol, Sarisky, Robert T, Kao, Cheng
Published in Virology (New York, N.Y.) (01.08.2003)
Published in Virology (New York, N.Y.) (01.08.2003)
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Intracellular hepatitis C virus RNA-dependent RNA polymerase activity
DeMarini, Douglas J, Johnston, Victor K, Konduri, Madhavi, Gutshall, Lester L, Sarisky, Robert T
Published in Journal of virological methods (01.10.2003)
Published in Journal of virological methods (01.10.2003)
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzo-thiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors
TEDESCO, Rosanna, DEPING CHAI, SHAW, Antony N, VALKO, Klara L, WIGGALL, Kenneth J, ZIMMERMAN, Michael N, DUFFY, Kevin J, DARCY, Michael G, DHANAK, Dashyant, FITCH, Duke M, GATES, Adam, JOHNSTON, Victor K, KEENAN, Richard M, LIN-GOERKE, Juili, SARISKY, Robert T
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
Journal Article
NOVEL ANTI-INFECTIVES
KEVIN, J. DUFFY, KAREN, A. EVANS, VICTOR, K. JOHNSTON, ROBERT, T. SARISKY, DUKE, M. FITCH, ADAM, T. GATES
Year of Publication 12.12.2003
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Year of Publication 12.12.2003
Patent
NOVEL ANTI-INFECTIVES
DUFFY, KEVIN, J, FITCH, DUKE, M, JOHNSTON, VICTOR, K, GATES, ADAM, T, EVANS, KAREN, A, SARISKY, ROBERT, T
Year of Publication 04.12.2003
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Year of Publication 04.12.2003
Patent