The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease
Huot, Philippe, Johnston, Tom H, Koprich, James B, Fox, Susan H, Brotchie, Jonathan M
Published in Pharmacological reviews (01.01.2013)
Published in Pharmacological reviews (01.01.2013)
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Journal Article
Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque
Koprich, James B, Johnston, Tom H, Reyes, Gabriela, Omana, Vanessa, Brotchie, Jonathan M
Published in PloS one (30.11.2016)
Published in PloS one (30.11.2016)
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Journal Article
Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein
Koprich, James B, Johnston, Tom H, Huot, Philippe, Reyes, M Gabriela, Espinosa, Maria, Brotchie, Jonathan M
Published in PloS one (07.03.2011)
Published in PloS one (07.03.2011)
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Journal Article
Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia
Brigham, Elizabeth, Johnston, Tom, Brown, Carl, Holt, Jonathon, Fox, Susan, Hill, Michael, Howson, Patrick, Brotchie, Jonathan, Nguyen, Jack
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
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Journal Article
Optical Properties of Dissolved Organic Matter and Their Relation to Mercury Concentrations in Water and Biota Across a Remote Freshwater Drainage Basin
Lescord, Gretchen L, Emilson, Erik J. S, Johnston, Tom A, Branfireun, Brian A, Gunn, John M
Published in Environmental science & technology (20.03.2018)
Published in Environmental science & technology (20.03.2018)
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Journal Article
Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease
Koprich, James B, Johnston, Tom H, Reyes, M Gabriela, Sun, Xuan, Brotchie, Jonathan M
Published in Molecular neurodegeneration (28.10.2010)
Published in Molecular neurodegeneration (28.10.2010)
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Journal Article
Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
Johnston, Tom H, Fox, Susan H, McIldowie, Matthew J, Piggott, Matthew J, Brotchie, Jonathan M
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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Journal Article
Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson's Disease
Howson, Patrick A, Johnston, Tom H, Ravenscroft, Paula, Hill, Michael P, Su, Jin, Brotchie, Jonathan M, Koprich, James B
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
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Journal Article
Using artificial intelligence to identify drugs for repurposing to treat l-DOPA-induced dyskinesia
Johnston, Tom H., Lacoste, Alix M.B., Ravenscroft, Paula, Su, Jin, Tamadon, Sahar, Seifi, Mahtab, Lang, Anthony E., Fox, Susan H., Brotchie, Jonathan M., Visanji, Naomi P.
Published in Neuropharmacology (01.05.2024)
Published in Neuropharmacology (01.05.2024)
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Journal Article
Pridopidine, a clinic‐ready compound, reduces 3,4‐dihydroxyphenylalanine‐induced dyskinesia in Parkinsonian macaques
Johnston, Tom H., Geva, Michal, Steiner, Lilach, Orbach, Aric, Papapetropoulos, Spyros, Savola, Juha‐Matti, Reynolds, Ian J., Ravenscroft, Paula, Hill, Michael, Fox, Susan H., Brotchie, Jonathan M., Laufer, Ralph, Hayden, Michael R.
Published in Movement disorders (01.05.2019)
Published in Movement disorders (01.05.2019)
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Journal Article
A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human primate models of Parkinson's disease
Schneider, Jay S., Marshall, Courtney A., Keibel, Lauren, Snyder, Nathaniel W., Hill, Michael P., Brotchie, Jonathan M., Johnston, Tom H., Waterhouse, Barry D., Kortagere, Sandhya
Published in Experimental neurology (01.01.2021)
Published in Experimental neurology (01.01.2021)
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Journal Article
Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease
Johnston, Tom H., Lacoste, Alix M.B., Visanji, Naomi P., Lang, Anthony E., Fox, Susan H., Brotchie, Jonathan M.
Published in Neuropharmacology (15.03.2019)
Published in Neuropharmacology (15.03.2019)
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Journal Article
A critique of available scales and presentation of the non-human primate dyskinesia rating scale
Fox, Susan H., Johnston, Tom H., Li, Qin, Brotchie, Jonathan, Bezard, Erwan
Published in Movement disorders (15.09.2012)
Published in Movement disorders (15.09.2012)
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Journal Article
Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice
Kirshenbaum, Greer S, Dawson, Neil, Mullins, Jonathan G L, Johnston, Tom H, Drinkhill, Mark J, Edwards, Ian J, Fox, Susan H, Pratt, Judith A, Brotchie, Jonathan M, Roder, John C, Clapcote, Steven J
Published in PloS one (20.03.2013)
Published in PloS one (20.03.2013)
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Journal Article
Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations
Huot, Philippe, Johnston, Tom H., Darr, Tayyeba, Hazrati, Lili-Naz, Visanji, Naomi P., Pires, Donna, Brotchie, Jonathan M., Fox, Susan H.
Published in Movement disorders (30.07.2010)
Published in Movement disorders (30.07.2010)
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Journal Article
l-DOPA pharmacokinetics in the MPTP-lesioned macaque model of Parkinson's disease
Huot, Philippe, Johnston, Tom H., Koprich, James B., Fox, Susan H., Brotchie, Jonathan M.
Published in Neuropharmacology (01.10.2012)
Published in Neuropharmacology (01.10.2012)
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Journal Article
TC-8831, a nicotinic acetylcholine receptor agonist, reduces l-DOPA-induced dyskinesia in the MPTP macaque
Johnston, Tom H., Huot, Philippe, Fox, Susan H., Koprich, James B., Szeliga, Kendall T., James, John W., Graef, John D., Letchworth, Sharon R., Jordan, Kristen G., Hill, Michael P., Brotchie, Jonathan M.
Published in Neuropharmacology (01.10.2013)
Published in Neuropharmacology (01.10.2013)
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Journal Article
Excess morbidity and mortality among survivors of childhood acute lymphoblastic leukaemia: 25 years of follow-up from the United Kingdom Childhood Cancer Study (UKCCS) population-based matched cohort
Kane, Eleanor, Kinsey, Sally, Bonaventure, Audrey, Johnston, Tom, Simpson, Jill, Howell, Debra, Smith, Alexandra, Roman, Eve
Published in BMJ open (07.03.2022)
Published in BMJ open (07.03.2022)
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