Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses
D'Souza, Warren N, Douangpanya, Jason, Mu, Sharon, Jaeckel, Peter, Zhang, Ming, Maxwell, Joseph R, Rottman, James B, Labitzke, Katja, Willee, Angela, Beckmann, Holger, Wang, Yingcai, Li, Yang, Schwandner, Ralf, Johnston, James A, Towne, Jennifer E, Hsu, Hailing
Published in PloS one (20.07.2017)
Published in PloS one (20.07.2017)
Get full text
Journal Article
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
Smith, Dirk, Helgason, Hannes, Sulem, Patrick, Bjornsdottir, Unnur Steina, Lim, Ai Ching, Sveinbjornsson, Gardar, Hasegawa, Haruki, Brown, Michael, Ketchem, Randal R, Gavala, Monica, Garrett, Logan, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Magnusson, Olafur T, Eyjolfsson, Gudmundur I, Olafsson, Isleifur, Onundarson, Pall Torfi, Sigurdardottir, Olof, Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn Runar, Ludviksdottir, Dora, Boezen, H Marike, Heinzmann, Andrea, Krueger, Marcus, Porsbjerg, Celeste, Ahluwalia, Tarunveer S, Waage, Johannes, Backer, Vibeke, Deichmann, Klaus A, Koppelman, Gerard H, Bønnelykke, Klaus, Bisgaard, Hans, Masson, Gisli, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Johnston, James A, Jonsdottir, Ingileif, Stefansson, Kari
Published in PLoS genetics (08.03.2017)
Published in PLoS genetics (08.03.2017)
Get full text
Journal Article
IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation
Floudas, Achilleas, Saunders, Sean P, Moran, Tara, Schwartz, Christian, Hams, Emily, Fitzgerald, Denise C, Johnston, James A, Ogg, Graham S, McKenzie, Andrew N, Walsh, Patrick T, Fallon, Padraic G
Published in The Journal of immunology (1950) (15.07.2017)
Published in The Journal of immunology (1950) (15.07.2017)
Get full text
Journal Article
Btk regulates macrophage polarization in response to lipopolysaccharide
Ní Gabhann, Joan, Hams, Emily, Smith, Siobhán, Wynne, Claire, Byrne, Jennifer C, Brennan, Kiva, Spence, Shaun, Kissenpfennig, Adrien, Johnston, James A, Fallon, Padraic G, Jefferies, Caroline A
Published in PloS one (21.01.2014)
Published in PloS one (21.01.2014)
Get full text
Journal Article
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
Miner, Kent, Labitzke, Katja, Liu, Benxian, Wang, Paul, Henckels, Kathryn, Gaida, Kevin, Elliott, Robin, Chen, Jian Jeffrey, Liu, Longbin, Leith, Anh, Trueblood, Esther, Hensley, Kelly, Xia, Xing-Zhong, Homann, Oliver, Bennett, Brian, Fiorino, Mike, Whoriskey, John, Yu, Gang, Escobar, Sabine, Wong, Min, Born, Teresa L, Budelsky, Alison, Comeau, Mike, Smith, Dirk, Phillips, Jonathan, Johnston, James A, McGivern, Joseph G, Weikl, Kerstin, Powers, David, Kunzelmann, Karl, Mohn, Deanna, Hochheimer, Andreas, Sullivan, John K
Published in Frontiers in pharmacology (14.02.2019)
Published in Frontiers in pharmacology (14.02.2019)
Get full text
Journal Article
Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Using the Elongin-Cullin E3 Ligase
ELLIOTT, Joanne, LYNCH, Oonagh T, POWER, Ultan F, JOHNSTON, James A, SUESSMUTH, Yvonne, PING QIAN, BOYD, Caroline R, BURROWS, James F, BUICK, Richard, STEVENSON, Nigel J, TOUZELET, Olivier, GADINA, Massimo
Published in Journal of Virology (01.04.2007)
Published in Journal of Virology (01.04.2007)
Get full text
Journal Article
Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis
BURDEN, Roberta E, GORMLEY, Julie A, SCOTT, Christopher J, JAQUIN, Thomas J, SMALL, Donna M, QUINN, Derek J, HEGARTY, Shauna M, WARD, Claire, WALKER, Brian, JOHNSTON, James A, OLWILL, Shane A
Published in Clinical cancer research (01.10.2009)
Published in Clinical cancer research (01.10.2009)
Get full text
Journal Article
The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
Hookham, Michelle B., Elliott, Joanne, Suessmuth, Yvonne, Staerk, Judith, Ward, Alister C., Vainchenker, William, Percy, Melanie J., McMullin, Mary Frances, Constantinescu, Stefan N., Johnston, James A.
Published in Blood (01.06.2007)
Published in Blood (01.06.2007)
Get full text
Journal Article
Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production
Boyd, Caroline R, Orr, Selinda J, Spence, Shaun, Burrows, James F, Elliott, Joanne, Carroll, Helen P, Brennan, Kiva, Gabhann, Joan Ni, Coulter, Wilson A, Johnston, James A, Jefferies, Caroline A
Published in The Journal of immunology (1950) (15.12.2009)
Published in The Journal of immunology (1950) (15.12.2009)
Get full text
Journal Article
A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17
Jaworski, Jakub, Govender, Ureshnie, McFarlane, Cheryl, de la Vega, Michelle, Greene, Michelle K, Rawlings, Neil D, Johnston, James A, Scott, Christopher J, Burrows, James F
Published in Biochemical journal (15.01.2014)
Published in Biochemical journal (15.01.2014)
Get more information
Journal Article
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
Orr, Selinda J., Morgan, Nuala M., Elliott, Joanne, Burrows, James F., Scott, Christopher J., McVicar, Daniel W., Johnston, James A.
Published in Blood (01.02.2007)
Published in Blood (01.02.2007)
Get full text
Journal Article
Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF
Ward, Claire, Kuehn, Diana, Burden, Roberta E, Gormley, Julie A, Jaquin, Thomas J, Gazdoiu, Mihaela, Small, Donna, Bicknell, Roy, Johnston, James A, Scott, Christopher J, Olwill, Shane A
Published in PloS one (02.09.2010)
Published in PloS one (02.09.2010)
Get full text
Journal Article
USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity
Burrows, James F., Kelvin, Alyson A., McFarlane, Cheryl, Burden, Roberta E., McGrattan, Michael J., De la Vega, Michelle, Govender, Ureshnie, Quinn, Derek J., Dib, Karim, Gadina, Massimo, Scott, Christopher J., Johnston, James A.
Published in The Journal of biological chemistry (03.04.2009)
Published in The Journal of biological chemistry (03.04.2009)
Get full text
Journal Article
Substitution of Pseudokinase Domain Residue Val-617 by Large Non-polar Amino Acids Causes Activation of JAK2
Dusa, Alexandra, Staerk, Judith, Elliott, Joanne, Pecquet, Christian, Poirel, Hélène A., Johnston, James A., Constantinescu, Stefan N.
Published in The Journal of biological chemistry (09.05.2008)
Published in The Journal of biological chemistry (09.05.2008)
Get full text
Journal Article
Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
Johnston, James A, Cacalano, Nicholas A, Sanden, David
Published in Nature cell biology (01.05.2001)
Published in Nature cell biology (01.05.2001)
Get full text
Journal Article
Retraction Notice to: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
Spence, Shaun, Fitzsimons, Amy, Boyd, Caroline R., Kessler, Julia, Fitzgerald, Denise, Elliott, Joanne, Gabhann, Joan Ní, Smith, Siobhan, Sica, Antonio, Hams, Emily, Saunders, Sean P., Jefferies, Caroline A., Fallon, Padraic G., McAuley, Danny F., Kissenpfennig, Adrien, Johnston, James A.
Published in Immunity (Cambridge, Mass.) (19.06.2014)
Published in Immunity (Cambridge, Mass.) (19.06.2014)
Get full text
Journal Article
Multiplex Immunoassay for Serological Diagnosis of Mycobacterium bovis Infection in Cattle
Whelan, Clare, Shuralev, Eduard, O'Keeffe, Grainne, Hyland, Paula, Kwok, Hang Fai, Snoddy, Philip, O'Brien, Amanda, Connolly, Marie, Quinn, Padraig, Groll, Matt, Watterson, Todd, Call, Sara, Kenny, Kevin, Duignan, Anthony, Hamilton, Mary Jo, Buddle, Bryce M., Johnston, James A., Davis, William C., Olwill, Shane A., Clarke, John
Published in Clinical and Vaccine Immunology (01.12.2008)
Published in Clinical and Vaccine Immunology (01.12.2008)
Get full text
Journal Article