The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
Beer, Nicola L., Tribble, Nicholas D., McCulloch, Laura J., Roos, Charlotta, Johnson, Paul R.V., Orho-Melander, Marju, Gloyn, Anna L.
Published in Human molecular genetics (01.11.2009)
Published in Human molecular genetics (01.11.2009)
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Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics
Brandhorst, Daniel, Brandhorst, Heide, Acreman, Samuel, Johnson, Paul R V
Published in Bioengineering (Basel) (01.08.2024)
Published in Bioengineering (Basel) (01.08.2024)
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GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
Gandasi, Nikhil R., Gao, Rui, Kothegala, Lakshmi, Pearce, Abigail, Santos, Cristiano, Acreman, Samuel, Basco, Davide, Benrick, Anna, Chibalina, Margarita V., Clark, Anne, Guida, Claudia, Harris, Matthew, Johnson, Paul R. V., Knudsen, Jakob G., Ma, Jinfang, Miranda, Caroline, Shigeto, Makoto, Tarasov, Andrei I., Yeung, Ho Yan, Thorens, Bernard, Asterholm, Ingrid W., Zhang, Quan, Ramracheya, Reshma, Ladds, Graham, Rorsman, Patrik
Published in Diabetologia (01.03.2024)
Published in Diabetologia (01.03.2024)
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Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
ROSENGREN, Anders H, BRAUN, Matthias, EDLUND, Anna, GRAM PEDERSEN, Morten, JONSSON, Anna, RAMRACHEYA, Reshma, YUNZHAO TANG, WALKER, Jonathan N, BARRETT, Amy, JOHNSON, Paul R. V, LYSSENKO, Valeriya, MCCARTHY, Mark I, MAHDI, Taman, GROOP, Leif, SALEHI, Albert, GLOYN, Anna L, RENSTRÖM, Erik, RORSMAN, Patrik, ELIASSON, Lena, ANDERSSON, Sofia A, TRAVERS, Mary E, SHIGETO, Makoto, ZHANG, Enming, ALMGREN, Peter, LADENVALL, Claes, AXELSSON, Annika S
Published in Diabetes (New York, N.Y.) (01.07.2012)
Published in Diabetes (New York, N.Y.) (01.07.2012)
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Factors influencing the collagenase digestion phase of human islet isolation
Kin, Tatsuya, Johnson, Paul R V, Shapiro, A M James, Lakey, Jonathan R T
Published in Transplantation (01.01.2007)
Published in Transplantation (01.01.2007)
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The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets
Yashiro, Hiroaki, Tsujihata, Yoshiyuki, Takeuchi, Koji, Hazama, Masatoshi, Johnson, Paul R V, Rorsman, Patrik
Published in The Journal of pharmacology and experimental therapeutics (01.02.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2012)
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Journal Article
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
MacDonald, Patrick E, De Marinis, Yang Zhang, Ramracheya, Reshma, Salehi, Albert, Ma, Xiaosong, Johnson, Paul R V, Cox, Roger, Eliasson, Lena, Rorsman, Patrik
Published in PLoS biology (01.06.2007)
Published in PLoS biology (01.06.2007)
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Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells
Gerber, Philipp A., Bellomo, Elisa A., Hodson, David J., Meur, Gargi, Solomou, Antonia, Mitchell, Ryan K., Hollinshead, Michael, Chimienti, Fabrice, Bosco, Domenico, Hughes, Stephen J., Johnson, Paul R. V., Rutter, Guy A.
Published in Diabetologia (01.08.2014)
Published in Diabetologia (01.08.2014)
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Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity
Brandhorst, Heide, Johnson, Paul R. V., Korsgren, Olle, Brandhorst, Daniel
Published in Cell transplantation (01.11.2017)
Published in Cell transplantation (01.11.2017)
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Journal Article
Donor age significantly influences the Raman spectroscopic biomolecular fingerprint of human pancreatic extracellular matrix proteins following collagenase-based digestion
Spiers, Rebecca M., Marzi, Julia, Brauchle, Eva M., Cross, Sarah E., Vaughan, Rebecca H., Bateman, Paul A., Hughes, Stephen J., Schenke-Layland, Katja, Johnson, Paul R.V.
Published in Acta biomaterialia (01.11.2019)
Published in Acta biomaterialia (01.11.2019)
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Proteomic Profiling Reveals the Ambivalent Character of the Mesenchymal Stem Cell Secretome: Assessing the Effect of Preconditioned Media on Isolated Human Islets
Brandhorst, Heide, Brandhorst, Daniel, Abraham, Anju, Acreman, Samuel, Schive, Simen W., Scholz, Hanne, Johnson, Paul R.V.
Published in Cell transplantation (01.01.2020)
Published in Cell transplantation (01.01.2020)
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Asymptomatic Children with Multiple Endocrine Neoplasia Type 1 Mutations May Harbor Nonfunctioning Pancreatic Neuroendocrine Tumors
Newey, Paul J, Jeyabalan, Jeshmi, Walls, Gerard V, Christie, Paul T, Gleeson, Fergus V, Gould, Steve, Johnson, Paul R. V, Phillips, Rachel R, Ryan, Fiona J, Shine, Brian, Bowl, Michael R, Thakker, Rajesh V
Published in The journal of clinical endocrinology and metabolism (01.10.2009)
Published in The journal of clinical endocrinology and metabolism (01.10.2009)
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Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation
Brandhorst, Daniel, Parnaud, Géraldine, Friberg, Andrew, Lavallard, Vanessa, Demuylder-Mischler, Sandrine, Hughes, Stephen, Saphörster, Julia, Kurfürst, Manfred, Korsgren, Olle, Berney, Thierry, Johnson, Paul R. V.
Published in Cell transplantation (01.10.2017)
Published in Cell transplantation (01.10.2017)
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Journal Article
Improved Baculovirus Vectors for Transduction and Gene Expression in Human Pancreatic Islet Cells
Graves, Leo P, Aksular, Mine, Alakeely, Riyadh A, Ruiz Buck, Daniel, Chambers, Adam C, Murguia-Meca, Fernanda, Plata-Muñoz, Juan-Jose, Hughes, Stephen, Johnson, Paul R V, Possee, Robert D, King, Linda A
Published in Viruses (20.10.2018)
Published in Viruses (20.10.2018)
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Perfluorodecalin-enriched fibrin matrix for human islet culture
Maillard, Elisa, Juszczak, Maciej T, Clark, Anne, Hughes, Stephen J, Gray, Derek R.W, Johnson, Paul R.V
Published in Biomaterials (01.12.2011)
Published in Biomaterials (01.12.2011)
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