The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects
Johnson, Christian W., Reid, Derion, Parker, Jillian A., Salter, Shores, Knihtila, Ryan, Kuzmic, Petr, Mattos, Carla
Published in The Journal of biological chemistry (04.08.2017)
Published in The Journal of biological chemistry (04.08.2017)
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Journal Article
Expression, purification, crystallization and X-ray data collection for RAS and its mutants
Johnson, Christian W., Buhrman, Greg, Ting, Pamela Y., Colicelli, John, Mattos, Carla
Published in Data in brief (01.03.2016)
Published in Data in brief (01.03.2016)
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Journal Article
Allosteric site variants affect GTP hydrolysis on Ras
Johnson, Christian W., Fetics, Susan K., Davis, Kathleen P., Rodrigues, Jose A., Mattos, Carla
Published in Protein science (01.10.2023)
Published in Protein science (01.10.2023)
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Journal Article
Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D
Johnson, Christian W., Lin, Yi-Jang, Reid, Derion, Parker, Jillian, Pavlopoulos, Spiro, Dischinger, Patrick, Graveel, Carrie, Aguirre, Andrew J., Steensma, Matthew, Haigis, Kevin M., Mattos, Carla
Published in Cell reports (Cambridge) (06.08.2019)
Published in Cell reports (Cambridge) (06.08.2019)
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Journal Article
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity
Yang, Moon Hee, Tran, Timothy H, Hunt, Bethany, Agnor, Rebecca, Johnson, Christian W, Shui, Bing, Waybright, Timothy J, Nowak, Jonathan A, Stephen, Andrew G, Simanshu, Dhirendra K, Haigis, Kevin M
Published in Cancer research (Chicago, Ill.) (02.10.2023)
Published in Cancer research (Chicago, Ill.) (02.10.2023)
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Journal Article
Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding
Ting, Pamela Y, Johnson, Christian W, Fang, Cong, Cao, Xiaoqing, Graeber, Thomas G, Mattos, Carla, Colicelli, John
Published in The FASEB journal (01.09.2015)
Published in The FASEB journal (01.09.2015)
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Journal Article
Regulation of GTPase function by autophosphorylation
Johnson, Christian W., Seo, Hyuk-Soo, Terrell, Elizabeth M., Yang, Moon-Hee, KleinJan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M.C., Geffken, Ezekiel A., Lakhani, Jimit, Song, Kijun, Bashyal, Puspalata, Popow, Olesja, Paulo, Joao A., Liu, Andrea, Mattos, Carla, Marshall, Christopher B., Ikura, Mitsuhiko, Morrison, Deborah K., Dhe-Paganon, Sirano, Haigis, Kevin M.
Published in Molecular cell (03.03.2022)
Published in Molecular cell (03.03.2022)
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Journal Article
DRoP: A Water Analysis Program Identifies Ras-GTP-Specific Pathway of Communication between Membrane-Interacting Regions and the Active Site
Kearney, Bradley M., Johnson, Christian W., Roberts, Daniel M., Swartz, Paul, Mattos, Carla
Published in Journal of molecular biology (06.02.2014)
Published in Journal of molecular biology (06.02.2014)
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Journal Article
The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
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Book Chapter
Journal Article
Tissue-Specific Oncogenic Activity of KRASA146T
Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian A., Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A., Westover, Kenneth D., Haigis, Kevin M.
Published in Cancer discovery (01.06.2019)
Published in Cancer discovery (01.06.2019)
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Journal Article
Abstract 84: Characterization of oncogenic KRAS A59 alleles and their cooperation with the MAPK signaling pathway
Johnson, Christian W., Terrell, Elizabeth M., Burd, Christin E., Morrison, Deborah, Haigis, Kevin M.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Tissue-specific oncogenic activity of K-RasA146T
Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian A., Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A., Westover, Kenneth D., Haigis, Kevin M.
Published in Cancer discovery (05.04.2019)
Published in Cancer discovery (05.04.2019)
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Journal Article
Tissue-Specific Oncogenic Activity of KRAS A146T
Poulin, Emily J, Bera, Asim K, Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A, Huang, Tannie Q, Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A, Brubaker, Douglas K, Joughin, Brian A, Johnson, Christian W, DeStefanis, Rebecca A, Ghazi, Phaedra C, Gondi, Sudershan, Wales, Thomas E, Iacob, Roxana E, Bogdanova, Lana, Gierut, Jessica J, Li, Yina, Engen, John R, Perez-Mancera, Pedro A, Braun, Benjamin S, Gygi, Steven P, Lauffenburger, Douglas A, Westover, Kenneth D, Haigis, Kevin M
Published in Cancer discovery (01.06.2019)
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Published in Cancer discovery (01.06.2019)
Journal Article
Allosteric regulation of switch-II controls K-Ras oncogenicity
Yang, Moon Hee, Tran, Timothy H, Hunt, Bethany, Agnor, Rebecca, Johnson, Christian W, Waybright, Timothy J, Nowak, Jonathan A, Stephen, Andrew G, Simanshu, Dhirendra K, Haigis, Kevin M
Published in bioRxiv (21.09.2022)
Published in bioRxiv (21.09.2022)
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Paper
Regulation of GTPase function by autophosphorylation
Johnson, Christian W, Hyuk-Soo Seo, Terrell, Elizabeth M, Kleinjan, Fenneke, Gebregiworgis, Teklab, Gasmi-Seabrook, Genevieve M C, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Popow, Olesja, Paulo, Joao A, Liu, Andrea, Mattos, Carla, Marshall, Christopher B, Ikura, Mitsuhiko, Morrison, Deborah K, Dhe-Paganon, Sirano, Haigis, Kevin M
Published in bioRxiv (23.06.2021)
Published in bioRxiv (23.06.2021)
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Paper
Obama's tax plan isn't much of a change
Scott W. Johnson Christian Science Monitor
Published in Deseret news (Salt Lake City, Utah : 1964) (19.10.2008)
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Published in Deseret news (Salt Lake City, Utah : 1964) (19.10.2008)
Newspaper Article