Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Martenyi, Ferenc, Monn, James A, Patil, Sandeep T, Zhang, Lu, Lowe, Stephen L, Jackson, Kimberley A, Andreev, Boris V, Avedisova, Alla S, Bardenstein, Leonid M, Gurovich, Issak Y, Morozova, Margarita A, Mosolov, Sergey N, Neznanov, Nikolai G, Reznik, Alexander M, Smulevich, Anatoly B, Tochilov, Vladimir A, Johnson, Bryan G, Schoepp, Darryle D
Published in Nature medicine (01.09.2007)
Published in Nature medicine (01.09.2007)
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Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (â)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
Fell, Matthew J, Svensson, Kjell A, Johnson, Bryan G, Schoepp, Darryle D
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
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CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography
Wright, Rebecca A., Johnson, Bryan G., Zhang, Ce, Salhoff, Craig, Kingston, Ann E., Calligaro, David O., Monn, James A., Schoepp, Darryle D., Marek, Gerard J.
Published in Neuropharmacology (01.03.2013)
Published in Neuropharmacology (01.03.2013)
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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders
RORICK-KEHN, Linda M, JOHNSON, Bryan G, SCHOEPP, Darryle D, KNITOWSKI, Karen M, SALHOFF, Craig R, WITKIN, Jeffrey M, PERRY, Kenneth W, GRIFFEY, Kelly I, TIZZANO, Joseph P, MONN, James A, MCKINZIE, David L
Published in Psychopharmacologia (01.07.2007)
Published in Psychopharmacologia (01.07.2007)
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Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (â)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039)
Rorick-Kehn, Linda M, Johnson, Bryan G, Burkey, Jennifer L, Wright, Rebecca A, Calligaro, David O, Marek, Gerard J, Nisenbaum, Eric S, Catlow, John T, Kingston, Ann E, Giera, Deborah D, Herin, Marc F, Monn, James A, McKinzie, David L, Schoepp, Darryle D
Published in The Journal of pharmacology and experimental therapeutics (01.04.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2007)
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In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (â)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268)
Fell, Matthew J, Perry, Kenneth W, Falcone, Julie F, Johnson, Bryan G, Barth, Vanessa N, Rash, Karen S, Lucaites, Virginia L, Threlkeld, Penny G, Monn, James A, McKinzie, David L, Marek, Gerard J, Svensson, Kjell A, Nelson, David L
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge
Fell, Matthew J., Katner, Jason S., Johnson, Bryan G., Khilevich, Albert, Schkeryantz, Jeffrey M., Perry, Kenneth W., Svensson, Kjell A.
Published in Neuropharmacology (01.03.2010)
Published in Neuropharmacology (01.03.2010)
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Improved Bioavailability of the mGlu2/3 Receptor Agonist LY354740 Using a Prodrug Strategy: In Vivo Pharmacology of LY544344
Rorick-Kehn, Linda M, Perkins, Everett J, Knitowski, Karen M, Hart, John C, Johnson, Bryan G, Schoepp, Darryle D, McKinzie, David L
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
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Synthesis and Pharmacological Characterization of C4 β -Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu 3 Receptor Agonist
Monn, James A, Henry, Steven S, Massey, Steven M, Clawson, David K, Chen, Qi, Diseroad, Benjamin A, Bhardwaj, Rajni M, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xu-Shan, Carter, Joan H, Getman, Brian G, Adragni, Kofi, Broad, Lisa M, Sanger, Helene E, Ursu, Daniel, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L, Hao, Junliang
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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[ 3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells
Johnson, Bryan G, Wright, Rebecca A, Arnold, M.Brian, Wheeler, William J, Ornstein, Paul L, Schoepp, Darryle D
Published in Neuropharmacology (01.10.1999)
Published in Neuropharmacology (01.10.1999)
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Metabotropic glutamate receptors in the control of mood disorders
Witkin, Jeffrey M, Marek, Gerard J, Johnson, Bryan G, Schoepp, Darryle D
Published in CNS & neurological disorders drug targets (01.04.2007)
Published in CNS & neurological disorders drug targets (01.04.2007)
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Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands
Sørensen, Ulrik S, Bleisch, Thomas J, Kingston, Anne E, Wright, Rebecca A, Johnson, Bryan G, Schoepp, Darryle D, Ornstein, Paul L
Published in Bioorganic & medicinal chemistry (17.01.2003)
Published in Bioorganic & medicinal chemistry (17.01.2003)
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Synthesis and Pharmacological Characterization of 4‑Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists
Monn, James A, Valli, Matthew J, Massey, Steven M, Hao, Junliang, Reinhard, Matthew R, Bures, Mark G, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Stephenson, Gregory A, Herin, Marc, Catlow, John T, Swanson, Steven, Johnson, Bryan G, McKinzie, David L, Henry, Steven S
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors
Monn, James A., Massey, Steven M., Valli, Matthew J., Henry, Steven S., Stephenson, Gregory A., Bures, Mark, Hérin, Marc, Catlow, John, Giera, Deborah, Wright, Rebecca A., Johnson, Bryan G., Andis, Sherri L., Kingston, Ann, Schoepp, Darryle D.
Published in Journal of medicinal chemistry (25.01.2007)
Published in Journal of medicinal chemistry (25.01.2007)
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Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740): Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors
Monn, James A, Valli, Matthew J, Massey, Steven M, Hansen, Marvin M, Kress, Thomas J, Wepsiec, James P, Harkness, Allen R, Grutsch, John L, Wright, Rebecca A, Johnson, Bryan G, Andis, Sherri L, Kingston, Ann, Tomlinson, Rosemarie, Lewis, Richard, Griffey, Kelly R, Tizzano, Joseph P, Schoepp, Darryle D
Published in Journal of medicinal chemistry (25.03.1999)
Published in Journal of medicinal chemistry (25.03.1999)
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Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors: Identification of a Subtype Selective mGlu2 Receptor Agonist
Dominguez, Carmen, Prieto, Lourdes, Valli, Matthew J, Massey, Steven M, Bures, Mark, Wright, Rebecca A, Johnson, Bryan G, Andis, Sherri L, Kingston, Ann, Schoepp, Darryle D, Monn, James A
Published in Journal of medicinal chemistry (19.05.2005)
Published in Journal of medicinal chemistry (19.05.2005)
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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties
Monn, James A, Valli, Matthew J, Massey, Steven M, Wright, Rebecca A, Salhoff, Craig R, Johnson, Bryan G, Howe, Trevor, Alt, Charles A, Rhodes, Gary A, Robey, Roger L, Griffey, Kelly R, Tizzano, Joseph P, Kallman, Mary J, Helton, David R, Schoepp, Darryle D
Published in Journal of medicinal chemistry (14.02.1997)
Published in Journal of medicinal chemistry (14.02.1997)
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The Orexin-1 Antagonist SB-334867 Blocks Antipsychotic Treatment-Emergent Catalepsy: Implications for the Treatment of Extrapyramidal Symptoms
Rasmussen, Kurt, Hsu, Mei-Ann, Noone, Stephen, Johnson, Bryan G., Thompson, Linda K., Hemrick-Luecke, Susan K.
Published in Schizophrenia bulletin (01.11.2007)
Published in Schizophrenia bulletin (01.11.2007)
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