Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity
Marsili, Alessandro, Aguayo-Mazzucato, Cristina, Chen, Ting, Kumar, Aditi, Chung, Mirra, Lunsford, Elaine P, Harney, John W, Van-Tran, Thuy, Gianetti, Elena, Ramadan, Waile, Chou, Cyril, Bonner-Weir, Susan, Larsen, Philip Reed, Silva, Jorge Enrique, Zavacki, Ann Marie
Published in PloS one (16.06.2011)
Published in PloS one (16.06.2011)
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Ubiquitination-Induced Conformational Change within the Deiodinase Dimer Is a Switch Regulating Enzyme Activity
Sagar, G. D. Vivek, Gereben, Balázs, Callebaut, Isabelle, Mornon, Jean-Paul, Zeöld, Anikó, da Silva, Wagner S., Luongo, Cristina, Dentice, Monica, Tente, Susana M., Freitas, Beatriz C. G., Harney, John W., Zavacki, Ann Marie, Bianco, Antonio C.
Published in Molecular and Cellular Biology (01.07.2007)
Published in Molecular and Cellular Biology (01.07.2007)
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The E3 Ubiquitin Ligase TEB4 Mediates Degradation of Type 2 Iodothyronine Deiodinase
Zavacki, Ann Marie, Arrojo e Drigo, Rafael, Freitas, Beatriz C. G., Chung, Mirra, Harney, John W., Egri, Péter, Wittmann, Gábor, Fekete, Csaba, Gereben, Balázs, Bianco, Antonio C.
Published in Molecular and Cellular Biology (01.10.2009)
Published in Molecular and Cellular Biology (01.10.2009)
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The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
Bianco, Antonio C, Dentice, Monica, Bandyopadhyay, Amitabha, Gereben, Balázs, Callebaut, Isabelle, Christoffolete, Marcelo A, Kim, Brian W, Nissim, Sahar, Mornon, Jean-Paul, Zavacki, Ann Marie, Zeöld, Anikó, Capelo, Luciane P, Curcio-Morelli, Cyntia, Ribeiro, Rogério, Harney, John W, Tabin, Clifford J
Published in Nature cell biology (01.07.2005)
Published in Nature cell biology (01.07.2005)
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The Small Polyphenolic Molecule Kaempferol Increases Cellular Energy Expenditure and Thyroid Hormone Activation
DA-SILVA, Wagner S, HARNEY, John W, KIRN, Brian W, JING LI, BIANCO, Suzy D. C, CRESCENZI, Alessandra, CHRISTOFFOLETE, Marcelo A, HUANG, Stephen A, BIANCO, Antonio C
Published in Diabetes (New York, N.Y.) (01.03.2007)
Published in Diabetes (New York, N.Y.) (01.03.2007)
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Type 2 Iodothyronine Deiodinase Levels Are Higher in Slow-Twitch than Fast-Twitch Mouse Skeletal Muscle and Are Increased in Hypothyroidism
Marsili, Alessandro, Ramadan, Waile, Harney, John W, Mulcahey, Michelle, Castroneves, Luciana Audi, Goemann, Iuri Martin, Wajner, Simone Magagnin, Huang, Stephen A, Zavacki, Ann Marie, Maia, Ana Luiza, Dentice, Monica, Salvatore, Domenico, Silva, J. Enrique, Larsen, P. Reed
Published in Endocrinology (Philadelphia) (01.12.2010)
Published in Endocrinology (Philadelphia) (01.12.2010)
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Supramolecular Complexes Mediate Selenocysteine Incorporation In Vivo
Small-Howard, Andrea, Morozova, Nadya, Stoytcheva, Zoia, Forry, Erin P., Mansell, John B., Harney, John W., Carlson, Bradley A., Xu, Xue-ming, Hatfield, Dolph L., Berry, Marla J.
Published in Molecular and Cellular Biology (01.03.2006)
Published in Molecular and Cellular Biology (01.03.2006)
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Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase
Marsili, Alessandro, Sanchez, Edith, Singru, Praful, Harney, John W, Zavacki, Ann Marie, Lechan, Ronald M, Larsen, P R
Published in Journal of endocrinology (01.10.2011)
Published in Journal of endocrinology (01.10.2011)
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Efficient Incorporation of Multiple Selenocysteines Involves an Inefficient Decoding Step Serving as a Potential Translational Checkpoint and Ribosome Bottleneck
Stoytcheva, Zoia, Tujebajeva, Rosa M, Harney, John W, Berry, Marla J
Published in Molecular and Cellular Biology (01.12.2006)
Published in Molecular and Cellular Biology (01.12.2006)
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Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation
Curcio-Morelli, Cyntia, Zavacki, Ann Marie, Christofollete, Marcelo, Gereben, Balazs, de Freitas, Beatriz C G, Harney, John W, Li, Zaibo, Wu, Guan, Bianco, Antonio C
Published in The Journal of clinical investigation (01.07.2003)
Published in The Journal of clinical investigation (01.07.2003)
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Atypical Expression of Type 2 Iodothyronine Deiodinase in Thyrotrophs Explains the Thyroxine-Mediated Pituitary Thyrotropin Feedback Mechanism
Christoffolete, Marcelo A, Ribeiro, Rogério, Singru, Praful, Fekete, Csaba, da Silva, Wagner S, Gordon, David F, Huang, Stephen A, Crescenzi, Alessandra, Harney, John W, Ridgway, E. Chester, Larsen, P. Reed, Lechan, Ronald M, Bianco, Antonio C
Published in Endocrinology (Philadelphia) (01.04.2006)
Published in Endocrinology (Philadelphia) (01.04.2006)
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The Iodothyronine Selenodeiodinases Are Thioredoxin-fold Family Proteins Containing a Glycoside Hydrolase Clan GH-A-like Structure
Callebaut, Isabelle, Curcio-Morelli, Cyntia, Mornon, Jean-P., Gereben, Balazs, Buettner, Christoph, Huang, Stephen, Castro, Bertrand, Fonseca, Tatiana L., Harney, John W., Larsen, P.Reed, Bianco, Antonio C.
Published in The Journal of biological chemistry (19.09.2003)
Published in The Journal of biological chemistry (19.09.2003)
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Human Type 3 Iodothyronine Selenodeiodinase Is Located in the Plasma Membrane and Undergoes Rapid Internalization to Endosomes
Baqui, Munira, Botero, Diego, Gereben, Balazs, Curcio, Cyntia, Harney, John W., Salvatore, Domenico, Sorimachi, Kenji, Larsen, P. Reed, Bianco, Antonio C.
Published in The Journal of biological chemistry (10.01.2003)
Published in The Journal of biological chemistry (10.01.2003)
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The Thyroid Hormone-Inactivating Deiodinase Functions as a Homodimer
Sagar, G. D. Vivek, Gereben, Balázs, Callebaut, Isabelle, Mornon, Jean-Paul, Zeöld, Anikó, Curcio-Morelli, Cyntia, Harney, John W, Luongo, Cristina, Mulcahey, Michelle A, Larsen, P. Reed, Huang, Stephen A, Bianco, Antonio C
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2008)
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2008)
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Decoding apparatus for eukaryotic selenocysteine insertion
Tujebajeva, Rosa M, Copeland, Paul R, Xu, Xue-Ming, Carlson, Bradley A, Harney, John W, Driscoll, Donna M, Hatfield, Dolph L, Berry, Marla J
Published in EMBO reports (01.08.2000)
Published in EMBO reports (01.08.2000)
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Agouti-Related Protein (AGRP) Has a Central Inhibitory Action on the Hypothalamic-Pituitary-Thyroid (HPT) Axis; Comparisons between the Effect of AGRP and Neuropeptide Y on Energy Homeostasis and the HPT Axis
Fekete, Csaba, Sarkar, Sumit, Rand, William M, Harney, John W, Emerson, Charles H, Bianco, Antonio C, Lechan, Ronald M
Published in Endocrinology (Philadelphia) (01.10.2002)
Published in Endocrinology (Philadelphia) (01.10.2002)
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Selective Proteolysis of Human Type 2 Deiodinase: A Novel Ubiquitin-Proteasomal Mediated Mechanism for Regulation of Hormone Activation
Gereben, Balázs, Goncalves, Carla, Harney, John W, Larsen, P. Reed, Bianco, Antonio C
Published in Molecular endocrinology (Baltimore, Md.) (01.11.2000)
Published in Molecular endocrinology (Baltimore, Md.) (01.11.2000)
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Nuclear Assembly of UGA Decoding Complexes on Selenoprotein mRNAs: a Mechanism for Eluding Nonsense-Mediated Decay?
de Jesus, Lucia A., Hoffmann, Peter R., Michaud, Tanya, Forry, Erin P., Small-Howard, Andrea, Stillwell, Robert J., Morozova, Nadya, Harney, John W., Berry, Marla J.
Published in Molecular and Cellular Biology (01.03.2006)
Published in Molecular and Cellular Biology (01.03.2006)
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Type 2 Iodothyronine Selenodeiodinase Is Expressed throughout the Mouse Skeleton and in the MC3T3-E1 Mouse Osteoblastic Cell Line during Differentiation
Gouveia, Cecilia H. A, Christoffolete, Marcelo A, Zaitune, Clarissa R, Dora, José Miguel, Harney, John W, Maia, Ana Luiza, Bianco, Antonio C
Published in Endocrinology (Philadelphia) (01.01.2005)
Published in Endocrinology (Philadelphia) (01.01.2005)
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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Ezaki, Osamu, Houten, Sander M, Christoffolete, Marcelo A, Schoonjans, Kristina, Sato, Hiroyuki, Watanabe, Mitsuhiro, Harney, John W, Auwerx, Johan, Mataki, Chikage, Bianco, Antonio C, Messaddeq, Nadia, Kim, Brian W, Kodama, Tatsuhiko
Published in Nature (26.01.2006)
Published in Nature (26.01.2006)
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