Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
Link, John O., Taylor, James G., Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Keller, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein
Lawitz, Eric J, Dvory-Sobol, Hadas, Doehle, Brian P, Worth, Angela S, McNally, John, Brainard, Diana M, Link, John O, Miller, Michael D, Mo, Hongmei
Published in Antimicrobial agents and chemotherapy (01.09.2016)
Published in Antimicrobial agents and chemotherapy (01.09.2016)
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Journal Article
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent
Kwon, Hyock Joo, Xing, Weimei, Chan, Katie, Niedziela-Majka, Anita, Brendza, Katherine M, Kirschberg, Thorsten, Kato, Darryl, Link, John O, Cheng, Guofeng, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (09.04.2015)
Published in PloS one (09.04.2015)
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Journal Article
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa
Link, John O., Taylor, James G., Trejo-Martin, Alejandra, Kato, Darryl, Katana, Ashley A., Krygowski, Evan S., Yang, Zheng-Yu, Zipfel, Sheila, Cottell, Jeromy J., Bacon, Elizabeth M., Tran, Chinh V., Yang, Cheng Y., Wang, Yujin, Wang, Kelly W., Zhao, Guangyu, Cheng, Guofeng, Tian, Yang, Gong, Ruoyu, Lee, Yu-Jen, Yu, Mei, Gorman, Eric, Mogalian, Erik, Perry, Jason K.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
Link, John O, Taylor, James G, Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Kellar, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
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Journal Article
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Yant, Stephen R, Mulato, Andrew, Hansen, Derek, Tse, Winston C, Niedziela-Majka, Anita, Zhang, Jennifer R, Stepan, George J, Jin, Debi, Wong, Melanie H, Perreira, Jill M, Singer, Eric, Papalia, Giuseppe A, Hu, Eric Y, Zheng, Jim, Lu, Bing, Schroeder, Scott D, Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R, Hung, Magdeleine, McDougall, William M, Brass, Abraham L, Sundquist, Wesley I, Cihlar, Tomas, Link, John O
Published in Nature medicine (01.09.2019)
Published in Nature medicine (01.09.2019)
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Journal Article
Lenacapavir Exhibits Atropisomerism—Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Zheng, Jim, Lu, Bing, Carr, Gavin, Mwangi, Judy, Wang, Kelly, Hao, Jia, Staiger, Kelly McLennan, Kozon, Nathan, Murray, Bernard P., Bashir, Mohammad, Gohdes, Mark A., Tse, Winston C., Schroeder, Scott, Graupe, Michael, Link, John O., Yoon, Jungjoo, Chiu, Anna, Rowe, William, Smith, Bill J., Subramanian, Raju
Published in The Journal of pharmacology and experimental therapeutics (01.10.2024)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2024)
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Journal Article
A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C
Lawitz, Eric J, Gruener, Daniel, Hill, John M, Marbury, Thomas, Moorehead, Lisa, Mathias, Anita, Cheng, Guofeng, Link, John O, Wong, Kelly A, Mo, Hongmei, McHutchison, John G, Brainard, Diana M
Published in Journal of hepatology (01.07.2012)
Published in Journal of hepatology (01.07.2012)
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Journal Article
In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir
Cheng, Guofeng, Tian, Yang, Doehle, Brian, Peng, Betty, Corsa, Amoreena, Lee, Yu-Jen, Gong, Ruoyu, Yu, Mei, Han, Bin, Xu, Simin, Dvory-Sobol, Hadas, Perron, Michel, Xu, Yili, Mo, Hongmei, Pagratis, Nikos, Link, John O, Delaney, William
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Journal Article
Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873
Kato, Darryl, Choy, Regina Wai-Yan, Canales, Eda, Dick, Ryan A., Lake, April D., Shapiro, Nathan D., Chin, Elbert, Li, Jiayao, Zhang, Jennifer R., Wu, Qiaoyin, Saito, Roland D., Metobo, Sammy, Aktoudianakis, Evangelos, Schroeder, Scott D., Yang, Zheng-Yu, Glatt, Dylan M., Balsitis, Scott, Gamelin, Lindsay, Yu, Mei, Cheng, Guofeng, Delaney, William E., Link, John O.
Published in ACS medicinal chemistry letters (11.04.2024)
Published in ACS medicinal chemistry letters (11.04.2024)
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Journal Article
539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans
Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C
Published in Open forum infectious diseases (26.11.2018)
Published in Open forum infectious diseases (26.11.2018)
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PYRROLO [1,2-b] PYRIDAZINE DERIVATIVE
JEROMY J COTTELL, JOHN O LINK, JAMES G TAYLOR, JENNIFER R ZHANG, ELIZABETH M BACON, YANG ZHENG-YU, GEDIMINAS BRIZGYS, CHOU CHIENHUNG, NATHAN E WRIGHT, ELBERT CHIN, TSE WINSTON C, SHEILA M ZIPFEL
Year of Publication 19.07.2023
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Year of Publication 19.07.2023
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Asymmetric Synthesis and Stereochemical Assignment of RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent
Smith, David B, Waltos, Ann Marie, Loughhead, David G, Weikert, Robert J, Morgans, David J, Rohloff, John C, Link, John O, Zhu, Rong-rong
Published in Journal of organic chemistry (22.03.1996)
Published in Journal of organic chemistry (22.03.1996)
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AMIDE COMPOUND FOR TREATMENT OF HIV
MICHAEL GRAUPE, SCOTT E LAZERWITH, GEDIMINAS BRIZGYS, RANDALL L HALCOMB, YUNFENG ERIC HU, CHOU CHIEN-HUNG, LIU QI, JOHN R SOMOZA, TSE WINSTON C, ROLAND D SAITO, SCOTT D SCHROEDER, JOHN O LINK, JENNIFER R ZHANG, LU YAFAN, EDA CANALES
Year of Publication 21.07.2023
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Year of Publication 21.07.2023
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HIV INHIBITOR COMPOUND
JEROMY J COTTELL, NATHAN SHAPIRO, DARRYL KATO, ASHLEY ANNE KATANA, JOHN O LINK, TERESA ALEJANDRA TREJO MARTIN, ELIZABETH M BACON, YANG ZHENG-YU, ELBERT CHIN
Year of Publication 13.05.2021
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Year of Publication 13.05.2021
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HIV INHIBITOR COMPOUND
JEROMY J COTTELL, NATHAN SHAPIRO, DARRYL KATO, ASHLEY ANNE KATANA, JOHN O LINK, TERESA ALEJANDRA TREJO MARTIN, ELIZABETH M BACON, YANG ZHENG-YU, ELBERT CHIN
Year of Publication 25.03.2021
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Year of Publication 25.03.2021
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THERAPEUTIC COMPOUNDS USEFUL FOR PROPHYLACTIC OR THERAPEUTIC TREATMENT OF HIV VIRUS INFECTION
MICHAEL GRAUPE, ROLAND D SAITO, SCOTT D SCHROEDER, JOHN O LINK, JENNIFER R ZHANG, CHARLES WILLIAM ROWE, TSE WINSTON C, DEMITRIOS STEFANIDIS, STEVEN J HENRY
Year of Publication 28.01.2021
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Year of Publication 28.01.2021
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