The Current State of Peptide Drug Discovery: Back to the Future?
Henninot, Antoine, Collins, James C, Nuss, John M
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Author Correction: Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo
Wong, Jeffrey Y. K., Ekanayake, Arunika I., Kharchenko, Serhii, Kirberger, Steven E., Qiu, Ryan, Kelich, Payam, Sarkar, Susmita, Li, Jiaqian, Fernandez, Kleinberg X., Alvizo-Paez, Edgar R., Miao, Jiayuan, Kalhor-Monfared, Shiva, John, J. Dwyer, Kang, Hongsuk, Choi, Hwanho, Nuss, John M., Vederas, John C., Lin, Yu-Shan, Macauley, Matthew S., Vukovic, Lela, Pomerantz, William C. K., Derda, Ratmir
Published in Nature communications (21.11.2023)
Published in Nature communications (21.11.2023)
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Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo
Wong, Jeffrey Y. K., Ekanayake, Arunika I., Kharchenko, Serhii, Kirberger, Steven E., Qiu, Ryan, Kelich, Payam, Sarkar, Susmita, Li, Jiaqian, Fernandez, Kleinberg X., Alvizo-Paez, Edgar R., Miao, Jiayuan, Kalhor-Monfared, Shiva, John, J. Dwyer, Kang, Hongsuk, Choi, Hwanho, Nuss, John M., Vederas, John C., Lin, Yu-Shan, Macauley, Matthew S., Vukovic, Lela, Pomerantz, William C. K., Derda, Ratmir
Published in Nature communications (13.09.2023)
Published in Nature communications (13.09.2023)
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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3
Wagman, Allan S, Boyce, Rustum S, Brown, Sean P, Fang, Eric, Goff, Dane, Jansen, Johanna M, Le, Vincent P, Levine, Barry H, Ng, Simon C, Ni, Zhi-Jie, Nuss, John M, Pfister, Keith B, Ramurthy, Savithri, Renhowe, Paul A, Ring, David B, Shu, Wei, Subramanian, Sharadha, Zhou, Xiaohui A, Shafer, Cynthia M, Harrison, Stephen D, Johnson, Kirk W, Bussiere, Dirksen E
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors
Ramurthy, Savithri, Pfister, Keith B., Boyce, Rustum S., Brown, Sean P., Costales, Abran Q., Desai, Manoj C., Fang, Eric, Levine, Barry H., Ng, Simon C., Nuss, John M., Ring, David B., Shafer, Cynthia M., Shu, Wei, Subramanian, Sharadha, Wagman, Allan S., Wang, Haixia, Bussiere, Dirksen E.
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo
RING, David B, JOHNSON, Kirk W, WAGMAN, Allan S, HAMMOND, Mary-Ellen Wernette, HARRISON, Stephen D, HENRIKSEN, Erik J, NUSS, John M, GOFF, Dane, KINNICK, Tyson R, MA, Sylvia T, REEDER, John W, SAMUELS, Isa, SLABIAK, Trina
Published in Diabetes (New York, N.Y.) (01.03.2003)
Published in Diabetes (New York, N.Y.) (01.03.2003)
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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)
Takeuchi, Craig S, Kim, Byung Gyu, Blazey, Charles M, Ma, Sunghoon, Johnson, Henry W. B, Anand, Neel K, Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A, Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S, Wang, Longcheng, Leahy, James W, Nuss, John M, Aay, Naing, Aoyama, Ron, Foster, Paul, Lee, Jae, Lehoux, Isabelle, Munagala, Narsimha, Plonowski, Arthur, Rajan, Sharmila, Woolfrey, John, Yamaguchi, Kyoko, Lamb, Peter, Miller, Nicole
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
Rice, Kenneth D, Aay, Naing, Anand, Neel K, Blazey, Charles M, Bowles, Owen J, Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K, Defina, Steven C, Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A, Kennedy, Abigail R, Kim, Angie I, Koltun, Elena S, Lougheed, Julie C, Manalo, Jean-Claire L, Martini, Jean-Francois, Nuss, John M, Peto, Csaba J, Tsang, Tsze H, Yu, Peiwen, Johnston, Stuart
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
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Discovery of XL413, a potent and selective CDC7 inhibitor
Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors
Leahy, James W, Buhr, Chris A, Johnson, Henry W. B, Kim, Byung Gyu, Baik, TaeGon, Cannoy, Jonah, Forsyth, Timothy P, Jeong, Joon Won, Lee, Matthew S, Ma, Sunghoon, Noson, Kevin, Wang, Longcheng, Williams, Matthew, Nuss, John M, Brooks, Eric, Foster, Paul, Goon, Leanne, Heald, Nathan, Holst, Charles, Jaeger, Christopher, Lam, Scott, Lougheed, Julie, Nguyen, Lam, Plonowski, Arthur, Song, Joanne, Stout, Thomas, Wu, Xiang, Yakes, Michael F, Yu, Peiwen, Zhang, Wentao, Lamb, Peter, Raeber, Olivia
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
Kim, Moon H., Tsuhako, Amy Lew, Co, Erick W., Aftab, Dana T., Bentzien, Frauke, Chen, Jason, Cheng, Wei, Engst, Stefan, Goon, Levina, Klein, Rhett R., Le, Donna T., Mac, Morrison, Parks, Jason J., Qian, Fawn, Rodriquez, Monica, Stout, Thomas J., Till, Jeffrey H., Won, Kwang-Ai, Wu, Xiang, Michael Yakes, F., Yu, Peiwen, Zhang, Wentao, Zhao, Yeping, Lamb, Peter, Nuss, John M., Xu, Wei
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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The design, synthesis, and biological evaluation of PIM kinase inhibitors
Tsuhako, Amy Lew, Brown, David S., Koltun, Elena S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Franzini, Maurizio, Galan, Adam, Huang, Ping, Johnston, Stuart, Kane, Brian, Kim, Moon H., Douglas Laird, A., Lin, Rui, Mock, Lillian, Ngan, Iris, Pack, Michael, Stott, Gordon, Stout, Thomas J., Yu, Peiwen, Zaharia, Cristiana, Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Kearney, Patrick C., Xu, Wei
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists
Ibrahim, Mohamed A, Johnson, Henry W. B, Jeong, Joon Won, Lewis, Gary L, Shi, Xian, Noguchi, Robin T, Williams, Matthew, Leahy, James W, Nuss, John M, Woolfrey, John, Banica, Monica, Bentzien, Frauke, Chou, Yu-Chien, Gibson, Anna, Heald, Nathan, Lamb, Peter, Mattheakis, Larry, Matthews, David, Shipway, Aaron, Wu, Xiang, Zhang, WenTao, Zhou, Sihong, Shankar, Geetha
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors
Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Discovery of a new class of glucosylceramide synthase inhibitors
Koltun, Elena, Richards, Steven, Chan, Vicky, Nachtigall, Jason, Du, Hongwang, Noson, Kevin, Galan, Adam, Aay, Naing, Hanel, Art, Harrison, Amanda, Zhang, Jeff, Won, Kwang-Ai, Tam, Danny, Qian, Fawn, Wang, Tao, Finn, Patricia, Ogilvie, Kathleen, Rosen, Jon, Mohan, Raju, Larson, Christopher, Lamb, Peter, Nuss, John, Kearney, Patrick
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Characterization of Novel Antimicrobial Peptoids
GOODSON, B, EHRHARDT, A, GIACONA, M. B, VITT, C, WINTER, J, NG, S, NUSS, J, JOHNSON, K, GIEDLIN, M, YAMAMOTO, R, MOOS, W. H, KREBBER, A, LADNER, M
Published in Antimicrobial Agents and Chemotherapy (01.06.1999)
Published in Antimicrobial Agents and Chemotherapy (01.06.1999)
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