ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors
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Published in Bioorganic & medicinal chemistry letters (15.08.2018)
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Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1
Come, Jon H, Senter, Timothy J, Clark, Michael P, Court, John J, Gale-Day, Zachary, Gu, Wenxin, Krueger, Elaine, Liang, Jianglin, Morris, Mark, Nanthakumar, Suganthini, O’Dowd, Hardwin, Maltais, Francois, Iyer, Ganesh, Andreassi, John, Boucher, Christina, Considine, Tony, Moody, Cameron S, Taylor, William, Mohanty, Arun K, Huang, Yulin, Zuccola, Harmon, Coll, Joyce, Bonanno, Kenneth C, Gagnon, Kevin J, Gan, Lu, Lu, Fan, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Song, Bin, Crawford, Dan, Doyle, Elisabeth, Kramer, Tal, Vought, Bryan, Phillips, Jonathan, Kemper, Raymond, Sanders, Martin, Swett, Rebecca, Furey, Brinley, Winquist, Ray, Bunnage, Mark E, Jackson, Katrina L, Charifson, Paul S, Magavi, Sanjay S
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J, Poisson, Carl, Ardzinski, Andrzej, Bilimoria, Darius, Chan, Laval, Chandupatla, Kishan, Chauret, Nathalie, Collier, Philip N, Das, Sanjoy Kumar, Denis, Francois, Dorsch, Warren, Iyer, Ganesh, Lauffer, David, L’Heureux, Lucille, Li, Pan, Luisi, Brian S, Mani, Nagraj, Nanthakumar, Suganthi, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S, Tang, Qing, Waal, Nathan D, Yannopoulos, Constantin G, Green, Jeremy
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates
Li, Pan, Dorsch, Warren, Lauffer, David J., Bilimoria, Darius, Chauret, Nathalie, Court, John J., Das, Sanjoy Kumar, Denis, Francois, Mani, Nagraj, Nanthakumar, Suganthini, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S., Stearns, Ralph, Tang, Qing, Waal, Nathan D., Green, Jeremy
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2
Clark, Michael P, Ledeboer, Mark W, Davies, Ioana, Byrn, Randal A, Jones, Steven M, Perola, Emanuele, Tsai, Alice, Jacobs, Marc, Nti-Addae, Kwame, Bandarage, Upul K, Boyd, Michael J, Bethiel, Randy S, Court, John J, Deng, Hongbo, Duffy, John P, Dorsch, Warren A, Farmer, Luc J, Gao, Huai, Gu, Wenxin, Jackson, Katrina, Jacobs, Dylan H, Kennedy, Joseph M, Ledford, Brian, Liang, Jianglin, Maltais, François, Murcko, Mark, Wang, Tiansheng, Wannamaker, M. Woods, Bennett, Hamilton B, Leeman, Joshua R, McNeil, Colleen, Taylor, William P, Memmott, Christine, Jiang, Min, Rijnbrand, Rene, Bral, Christopher, Germann, Ursula, Nezami, Azin, Zhang, Yuegang, Salituro, Francesco G, Bennani, Youssef L, Charifson, Paul S
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
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Design and synthesis of novel conformationally restricted HIV protease inhibitors
Salituro, Francesco G., Baker, Christopher T., Court, John J., Deininger, David D., Kim, Eunice E., Li, Biquin, Novak, Perry M., Rao, Bhisetti G., Pazhanisamy, S., Porter, Margaret D., Schairer, Wayne C., Tung, Roger D.
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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2,6-Disubstituted Aryl Carboxylic Acids, Leaving Groups "Par Excellence" for Benzisothiazolone Inhibitors of Human Leukocyte Elastase
Subramanyam, Chakrapani, Bell, Malcolm R, Carabateas, Philip, Court, John J, Dority, John A. Jr, Ferguson, Edward, Gordon, Robert, Hlasta, Dennis J, Kumar, Virendra
Published in Journal of medicinal chemistry (01.08.1994)
Published in Journal of medicinal chemistry (01.08.1994)
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A Novel Class of Cyclic .beta.-Dicarbonyl Leaving Groups and Their Use in the Design of Benzisothiazolone Human Leukocyte Elastase Inhibitors
Hlasta, Dennis J, Ackerman, James H, Court, John J, Farrell, Robert P, Johnson, Judith A, Kofron, James L, Robinson, David T, Talomie, Timothy G, Dunlap, Richard P, Franke, Catherine A
Published in Journal of medicinal chemistry (01.11.1995)
Published in Journal of medicinal chemistry (01.11.1995)
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2,6-Disubstituted Aryl Carboxylic Acids, Leaving Groups "Par Excellence" for Benzisothiazolone Inhibitors of Human Leukocyte Elastase. [Erratum to document cited in CA121:230709]
Subramanyam, Chakrapani, Bell, Malcolm R, Carabateas, Philip, Court, John J, Dority, John A. Jr, Ferguson, Edward, Gordon, Robert, Hlasta, Dennis J, Kumar, Virendra
Published in Journal of medicinal chemistry (01.08.1995)
Published in Journal of medicinal chemistry (01.08.1995)
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Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization
Perni, Robert B., Pitlik, Janos, Britt, Shawn D., Court, John J., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Levin, Rhonda B., Lin, Chao, Lin, Kai, Moon, Young-Choon, Luong, Yu-Ping, O'Malley, Ethan T., Rao, B.Govinda, Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Year of Publication 14.11.2023
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Year of Publication 14.11.2023
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Inhibitors of hepatitis C virus NS3.4A protease. Part 3: P2 proline variants
PERNI, Robert B, FARMER, Luc J, KAI LIN, LUONG, Yu-Ping, MAXWELL, John P, MURCKO, Mark A, PITLIK, Janos, GOVINDA RAO, B, SCHAIRER, Wayne C, TUNG, Roger D, VAN DRIE, John H, WILSON, Keith, COTTRELL, Kevin M, THOMSON, John A, COURT, John J, COURTNEY, Lawrence F, DEININGER, David D, GATES, Cynthia A, HARBESON, Scott L, KIM, Joseph L, CHAO LIN
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization
PERNI, Robert B, PITLIK, Janos, CHAO LIN, KAI LIN, MOON, Young-Choon, LUONG, Yu-Ping, O'MALLEY, Ethan T, GOVINDA RAO, B, THOMSON, John A, TUNG, Roger D, VAN DRIE, John H, YUNYI WEI, BRITT, Shawn D, COURT, John J, COURTNEY, Lawrence F, DEININGER, David D, FARMER, Luc J, GATES, Cynthia A, HARBESON, Scott L, LEVIN, Rhonda B
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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SUBSTITUTED QUINOXALINE DNA-PK INHIBITORS
Jackson, Katrina Lee, Maxwell, John Patrick, Li, Pan, Gu, Wenxin, Ronkin, Steven M, Deng, Hongbo, Court, John J, Morris, Mark A, Charifson, Paul S, Giroux, Simon, Xu, Jinwang, Pierce, Albert Charles, Cottrell, Kevin Michael, Tang, Qing, Lauffer, David J, Waal, Nathan D
Year of Publication 07.09.2023
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Year of Publication 07.09.2023
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