Synthetic studies toward a simplified eleuthoside core
Scola, Paul M., Kadow, John F., Langley, David, Vyas, Dolatrai
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
Get full text
Journal Article
Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action
Langley, David R., Roy Kimura, S., Sivaprakasam, Prasanna, Zhou, Nannan, Dicker, Ira, McAuliffe, Brian, Wang, Tao, Kadow, John F., Meanwell, Nicholas A., Krystal, Mark
Published in Proteins, structure, function, and bioinformatics (01.02.2015)
Published in Proteins, structure, function, and bioinformatics (01.02.2015)
Get full text
Journal Article
In Vitro Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068
NOWICKA-SANS, Beata, GONG, Yi-Fei, LI ZHU, MAJUMDAR, Antara, STOCK, David, LATAILLADE, Max, HANNA, George J, MATISKELLA, John D, UEDA, Yasutsugu, TAO WANG, KADOW, John F, MEANWELL, Nicholas A, MCAULIFFE, Brian, KRYSTAL, Mark, DICKER, Ira, HO, Hsu-Tso, NANNAN ZHOU, EGGERS, Betsy, LIN, Pin-Fang, RAY, Neelanjana, WIND-ROTOLO, Megan
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Get full text
Journal Article
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
LEMM, Julie A, MENGPING LIU, KNIPE, Jay O, COLONNO, Richard, MEANWELL, Nicholas A, KADOW, John F, SANTONE, Kenneth S, ROBERTS, Susan B, MIN GAO, GENTLES, Robert G, MIN DING, VOSS, Stacey, PELOSI, Lenore A, WANG, Ying-Kai, RIGAT, Karen L, MOSURE, Kathleen W, BENDER, John A
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Get full text
Journal Article
AlMe3-Promoted Formation of Amides from Acids and Amines
Li, Jianqing, Subramaniam, Krishnananthan, Smith, Daniel, Qiao, Jennifer X, Li, Jie Jack, Qian-Cutrone, Jingfang, Kadow, John F, Vite, Gregory D, Chen, Bang-Chi
Published in Organic letters (06.01.2012)
Published in Organic letters (06.01.2012)
Get full text
Journal Article
Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents
Yeung, Kap-Sun, Qiu, Zhilei, Xue, Quifen, Fang, Haiquan, Yang, Zheng, Zadjura, Lisa, D’Arienzo, Celia J., Eggers, Betsy J., Riccardi, Keith, Shi, Pei-Yong, Gong, Yi-Fei, Browning, Marc R., Gao, Qi, Hansel, Steven, Santone, Kenneth, Lin, Ping-Fang, Meanwell, Nicholas A., Kadow, John F.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Get full text
Journal Article
Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors
Yeung, Kap-Sun, Qiu, Zhilei, Yin, Zhiwei, Trehan, Ashok, Fang, Haiquan, Pearce, Bradley, Yang, Zheng, Zadjura, Lisa, D’Arienzo, Celia J., Riccardi, Keith, Shi, Pei-Yong, Spicer, Timothy P., Gong, Yi-Fei, Browning, Marc R., Hansel, Steven, Santone, Kenneth, Barker, Jonathan, Coulter, Thomas, Lin, Ping-Fang, Meanwell, Nicholas A., Kadow, John F.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Get full text
Journal Article
Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives
Wang, Tao, Kadow, John F., Zhang, Zhongxing, Yin, Zhiwei, Gao, Qi, Wu, Dedong, Parker, Dawn DiGiugno, Yang, Zheng, Zadjura, Lisa, Robinson, Brett A., Gong, Yi-Fei, Blair, Wade S., Shi, Pei-Yong, Yamanaka, Gregory, Lin, Pin-Fang, Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Get full text
Journal Article
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Get full text
Journal Article
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase
Ding, Min, He, Feng, Hudyma, Thomas W., Zheng, Xiaofan, Poss, Michael A., Kadow, John F., Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert A., Lemm, Julie A., Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore A., Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Get full text
Journal Article
Inhibitors of HIV‑1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir
Meanwell, Nicholas A, Krystal, Mark R, Nowicka-Sans, Beata, Langley, David R, Conlon, David A, Eastgate, Martin D, Grasela, Dennis M, Timmins, Peter, Wang, Tao, Kadow, John F
Published in Journal of medicinal chemistry (11.01.2018)
Published in Journal of medicinal chemistry (11.01.2018)
Get full text
Journal Article
Antiviral Properties of HIV-1 Capsid Inhibitor GSK878
Wang, Chunfu, Huang, Haichang, Mallon, Kirsten, Valera, Lourdes, Parcella, Kyle, Cockett, Mark I, Kadow, John F, Gillis, Eric P, Krystal, Mark, Fridell, Robert A
Published in Antimicrobial agents and chemotherapy (17.05.2023)
Published in Antimicrobial agents and chemotherapy (17.05.2023)
Get full text
Journal Article
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir
Wang, Tao, Ueda, Yasu, Zhang, Zhongxing, Yin, Zhiwei, Matiskella, John, Pearce, Bradley C, Yang, Zheng, Zheng, Ming, Parker, Dawn D, Yamanaka, Gregory A, Gong, Yi-Fei, Ho, Hsu-Tso, Colonno, Richard J, Langley, David R, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
Get full text
Journal Article
Potent Long-Acting Inhibitors Targeting the HIV‑1 Capsid Based on a Versatile Quinazolin-4-one Scaffold
Gillis, Eric P., Parcella, Kyle, Bowsher, Michael, Cook, James H., Iwuagwu, Christiana, Naidu, B. Narasimhulu, Patel, Manoj, Peese, Kevin, Huang, Haichang, Valera, Lourdes, Wang, Chunfu, Kieltyka, Kasia, Parker, Dawn D., Simmermacher, Jean, Arnoult, Eric, Nolte, Robert T., Wang, Liping, Bender, John A., Frennesson, David B., Saulnier, Mark, Wang, Alan Xiangdong, Meanwell, Nicholas A., Belema, Makonen, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Kadow, John F., Cockett, Mark, Fridell, Robert
Published in Journal of medicinal chemistry (09.02.2023)
Published in Journal of medicinal chemistry (09.02.2023)
Get full text
Journal Article
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV‑1 Protease Inhibitor Atazanavir
A. M. Subbaiah, Murugaiah, Mandlekar, Sandhya, Desikan, Sridhar, Ramar, Thangeswaran, Subramani, Lakshumanan, Annadurai, Mathiazhagan, Desai, Salil D, Sinha, Sarmistha, Jenkins, Susan M, Krystal, Mark R, Subramanian, Murali, Sridhar, Srikanth, Padmanabhan, Shweta, Bhutani, Priyadeep, Arla, Rambabu, Singh, Shashyendra, Sinha, Jaydeep, Thakur, Megha, Kadow, John F, Meanwell, Nicholas A
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
Get full text
Journal Article
A General Method for the Preparation of 4- and 6-Azaindoles
Zhang, Zhongxing, Yang, Zhong, Meanwell, Nicholas A, Kadow, John F, Wang, Tao
Published in Journal of organic chemistry (05.04.2002)
Published in Journal of organic chemistry (05.04.2002)
Get full text
Journal Article
New dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Vite, Gregory D., Mastalerz, Harold, Kadow, John F., Kim, Soong-Hoon, Leavitt, Kenneth J., Du, Karen, Crews, Donald, Mitt, Toomas, Wong, Tai W., Hunt, John T., Vyas, Dolatrai M., Tokarski, John S.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Get full text
Journal Article