Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
Williams, Pete A, Tribble, James R, Pepper, Keating W, Cross, Stephen D, Morgan, B Paul, Morgan, James E, John, Simon W M, Howell, Gareth R
Published in Molecular neurodegeneration (06.04.2016)
Published in Molecular neurodegeneration (06.04.2016)
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Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma
Williams, Pete A, Howell, Gareth R, Barbay, Jessica M, Braine, Catherine E, Sousa, Gregory L, John, Simon W M, Morgan, James E
Published in PloS one (19.08.2013)
Published in PloS one (19.08.2013)
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GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
Nair, K. Saidas, Srivastava, Chitrangda, Brown, Robert V., Koli, Swanand, Choquet, Hélène, Kang, Hong Soon, Kuo, Yien-Ming, Grimm, Sara A., Sutherland, Caleb, Badea, Alexandra, Johnson, G. Allan, Zhao, Yin, Yin, Jie, Okamoto, Kyoko, Clark, Graham, Borrás, Terete, Zode, Gulab, Kizhatil, Krishnakumar, Chakrabarti, Subhabrata, John, Simon W. M., Jorgenson, Eric, Jetten, Anton M.
Published in Nature communications (12.08.2021)
Published in Nature communications (12.08.2021)
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Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice
Tribble, James R, Harder, Jeffrey M, Williams, Pete A, John, Simon W M
Published in Molecular brain (25.05.2020)
Published in Molecular brain (25.05.2020)
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Journal Article
Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma
Berry, Ryan H, Qu, Juan, John, Simon W M, Howell, Gareth R, Jakobs, Tatjana C
Published in PloS one (04.12.2015)
Published in PloS one (04.12.2015)
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Journal Article
Mutations in Col4a1 Cause Perinatal Cerebral Hemorrhage and Porencephaly
Gould, Douglas B., Phalan, F. Campbell, Breedveld, Guido J., van Mil, Saskia E., Smith, Richard S., Schimenti, John C., Aguglia, Umberto, van der Knaap, Marjo S., Heutink, Peter, Simon W. M. John
Published in Science (American Association for the Advancement of Science) (20.05.2005)
Published in Science (American Association for the Advancement of Science) (20.05.2005)
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Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
Williams, Pete A, Braine, Catherine E, Kizhatil, Krishnakumar, Foxworth, Nicole E, Tolman, Nicholas G, Harder, Jeffrey M, Scott, Rebecca A, Sousa, Gregory L, Panitch, Alyssa, Howell, Gareth R, John, Simon W M
Published in Molecular neurodegeneration (22.01.2019)
Published in Molecular neurodegeneration (22.01.2019)
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Journal Article
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
Howell, Gareth R, Libby, Richard T, Jakobs, Tatjana C, Smith, Richard S, Phalan, F. Campbell, Barter, Joseph W, Barbay, Jessica M, Marchant, Jeffrey K, Mahesh, Nagaraju, Porciatti, Vittorio, Whitmore, Alan V, Masland, Richard H, John, Simon W.M
Published in The Journal of cell biology (31.12.2007)
Published in The Journal of cell biology (31.12.2007)
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Mutations in a P-type ATPase gene cause axonal degeneration
Zhu, Xianjun, Libby, Richard T, de Vries, Wilhelmine N, Smith, Richard S, Wright, Dana L, Bronson, Roderick T, Seburn, Kevin L, John, Simon W M
Published in PLoS genetics (01.08.2012)
Published in PLoS genetics (01.08.2012)
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Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice
Nair, K Saidas, Hmani-Aifa, Mounira, Ali, Zain, Kearney, Alison L, Salem, Salma Ben, Macalinao, Danilo G, Cosma, Ioan M, Bouassida, Walid, Hakim, Bochra, Benzina, Zeineb, Soto, Ileana, Söderkvist, Peter, Howell, Gareth R, Smith, Richard S, Ayadi, Hammadi, John, Simon W M
Published in Nature genetics (01.06.2011)
Published in Nature genetics (01.06.2011)
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DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation
Soto, Ileana, Howell, Gareth R, John, Cai W, Kief, Joseph L, Libby, Richard T, John, Simon W M
Published in PloS one (10.09.2014)
Published in PloS one (10.09.2014)
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Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice
Williams, Pete A., Harder, Jeffrey M., Foxworth, Nicole E., Cochran, Kelly E., Philip, Vivek M., Porciatti, Vittorio, Smithies, Oliver, John, Simon W. M.
Published in Science (American Association for the Advancement of Science) (17.02.2017)
Published in Science (American Association for the Advancement of Science) (17.02.2017)
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Journal Article
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial
De Moraes, Carlos Gustavo, John, Simon W M, Williams, Pete A, Blumberg, Dana M, Cioffi, George A, Liebmann, Jeffrey M
Published in JAMA ophthalmology (01.01.2022)
Published in JAMA ophthalmology (01.01.2022)
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A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
Choquet, Hélène, Paylakhi, Seyyedhassan, Kneeland, Stephen C., Thai, Khanh K., Hoffmann, Thomas J., Yin, Jie, Kvale, Mark N., Banda, Yambazi, Tolman, Nicholas G., Williams, Pete A., Schaefer, Catherine, Melles, Ronald B., Risch, Neil, John, Simon W. M., Nair, K. Saidas, Jorgenson, Eric
Published in Nature communications (11.06.2018)
Published in Nature communications (11.06.2018)
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Journal Article
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process
Kizhatil, Krishnakumar, Ryan, Margaret, Marchant, Jeffrey K, Henrich, Stephen, John, Simon W M
Published in PLoS biology (01.07.2014)
Published in PLoS biology (01.07.2014)
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Transcriptomic profiling of Schlemm's canal cells reveals a lymphatic-biased identity and three major cell states
Balasubramanian, Revathi, Kizhatil, Krishnakumar, Li, Taibo, Tolman, Nicholas, Bhandari, Aakriti, Clark, Graham, Bupp-Chickering, Violet, Kelly, Ruth A, Zhou, Sally, Peregrin, John, Simón, Marina, Montgomery, Christa, Stamer, W Daniel, Qian, Jiang, John, Simon W M
Published in eLife (18.10.2024)
Published in eLife (18.10.2024)
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