Profound Antiviral Effect of Oral Administration of MIV-210 on Chronic Hepadnaviral Infection in a Woodchuck Model of Hepatitis B
Michalak, Tomasz I, Zhang, Hong, Churchill, Norma D, Larsson, Torbjörn, Johansson, Nils-Gunnar, Oberg, Bo
Published in Antimicrobial Agents and Chemotherapy (01.09.2009)
Published in Antimicrobial Agents and Chemotherapy (01.09.2009)
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Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors
HOMBROUCK, Anneleen, VAN REMOORTEL, Barbara, LETIZIA BARRECA, Maria, DE LUCA, Laura, FERRO, Stefania, CHIMIRRI, Alba, DEBYSER, Zeger, WITVROUW, Myriam, MICHIELS, Martine, NOPPE, Wim, CHRIST, Frauke, ENEROTH, Anders, SAHLBERG, Britt Louise, BENKESTOCK, Kurt, VRANG, Lotta, GUNNAR JOHANSSON, Nils
Published in Antimicrobial Agents and Chemotherapy (01.08.2008)
Published in Antimicrobial Agents and Chemotherapy (01.08.2008)
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Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity
Pérez-Moreno, Guiomar, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Johansson, Nils Gunnar, Müller, Sylke, Baragaña, Beatriz, Hampton, Shahienaz Emma, Gilbert, Ian Hugh, Kaiser, Marcel, Sarkar, Sandipan, Pandurangan, Thiyagamurthy, Kumar, Vijeesh, González-Pacanowska, Dolores
Published in Malaria journal (03.12.2019)
Published in Malaria journal (03.12.2019)
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Journal Article
Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase
McCarthy, Orla, Musso-Buendia, Alex, Kaiser, Marcel, Brun, Reto, Ruiz-Perez, Luis M., Johansson, Nils Gunnar, Pacanowska, Dolores Gonzalez, Gilbert, Ian H.
Published in European journal of medicinal chemistry (01.02.2009)
Published in European journal of medicinal chemistry (01.02.2009)
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Journal Article
β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase
Baragaña, Beatriz, McCarthy, Orla, Sánchez, Paula, Bosch-Navarrete, Cristina, Kaiser, Marcel, Brun, Reto, Whittingham, Jean L., Roberts, Shirley M., Zhou, Xiao-Xiong, Wilson, Keith S., Johansson, Nils Gunnar, González-Pacanowska, Dolores, Gilbert, Ian H.
Published in Bioorganic & medicinal chemistry (01.04.2011)
Published in Bioorganic & medicinal chemistry (01.04.2011)
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Journal Article
Acyclic Nucleoside Analogues as Inhibitors of Plasmodium falciparum dUTPase
NGUYEN, Corinne, RUDA, Gian Filippo, SCHIPANI, Alessandro, KASINATHAN, Ganasan, LEAL, Isabel, MUSSO-BUENDIA, Alexander, KAISER, Marcel, BRUN, Reto, RUIZ-PéREZ, Luis M., SAHLBERG, Britt-Louise, JOHANSSON, Nils Gunnar, GONZáLEZ-PACANOWSKA, Dolores, GILBERT, Ian H.
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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dUTPase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors
Whittingham, Jean L., Leal, Isabel, Nguyen, Corinne, Kasinathan, Ganasan, Bell, Emma, Jones, Andrew F., Berry, Colin, Benito, Agustin, Turkenburg, Johan P., Dodson, Eleanor J., Perez, Luis M. Ruiz, Wilkinson, Anthony J., Johansson, Nils Gunnar, Brun, Reto, Gilbert, Ian H., Pacanowska, Dolores Gonzalez, Wilson, Keith S.
Published in Structure (London) (01.02.2005)
Published in Structure (London) (01.02.2005)
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Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs
Bell, Frank W, Cantrell, Amanda S, Hoegberg, Marita, Jaskunas, S. Richard, Johansson, Nils Gunnar, Jordan, Christopher L, Kinnick, Michael D, Lind, Peter, Morin, John M
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Journal Article
Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs
Eriksson, Staffan, Kierdaszuk, Borys, Munch-Petersen, Birgitte, Oberg, Bo, Gunnar Johansson, Nils
Published in Biochemical and biophysical research communications (30.04.1991)
Published in Biochemical and biophysical research communications (30.04.1991)
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Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogs
Cantrell, Amanda S, Engelhardt, Per, Högberg, Marita, Jaskunas, S. Richard, Johansson, Nils Gunnar, Jordan, Christopher L, Kangasmetsä, Jussi, Kinnick, Michael D, Lind, Peter, Morin, John M, Muesing, M. A, Noreén, Rolf, Öberg, Bo, Pranc, Paul, Sahlberg, Christer, Ternansky, Robert J, Vasileff, Robert T, Vrang, Lotta, West, Sarah J, Zhang, Hong
Published in Journal of medicinal chemistry (11.10.1996)
Published in Journal of medicinal chemistry (11.10.1996)
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Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease
Harrison, Justin R, Sarkar, Sandipan, Hampton, Shahienaz, Riley, Jennifer, Stojanovski, Laste, Sahlberg, Christer, Appelqvist, Pia, Erath, Jessey, Mathan, Vinodhini, Rodriguez, Ana, Kaiser, Marcel, Pacanowska, Dolores Gonzalez, Read, Kevin D, Johansson, Nils Gunnar, Gilbert, Ian H
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine
Smith, David B, Kalayanov, Genadiy, Sund, Christian, Winqvist, Anna, Maltseva, Tatiana, Leveque, Vincent J.-P, Rajyaguru, Sonal, Pogam, Sophie Le, Najera, Isabel, Benkestock, Kurt, Zhou, Xiao-Xiong, Kaiser, Ann C, Maag, Hans, Cammack, Nick, Martin, Joseph A, Swallow, Steven, Johansson, Nils Gunnar, Klumpp, Klaus, Smith, Mark
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
Synthesis and antiviral activity of prodrugs of the nucleoside 1-[2′,3′-Dideoxy-3′-C-(hydroxymethyl)-β- d-erythropentofuranosyl] cytosine
Mauldin, Scott C., Paget Jr, C.J., Jones, C.David, Colacino, Joseph M., Baxter, Angela J., Staschke, Kirk A., Johansson, Nils-Gunnar, Vrang, Lotta
Published in Bioorganic & medicinal chemistry (01.05.1998)
Published in Bioorganic & medicinal chemistry (01.05.1998)
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Journal Article
2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups
Klumpp, Klaus, Kalayanov, Genadiy, Ma, Han, Le Pogam, Sophie, Leveque, Vincent, Jiang, Wen-Rong, Inocencio, Nicole, De Witte, Anniek, Rajyaguru, Sonal, Tai, Ezra, Chanda, Sushmita, Irwin, Michael R., Sund, Christian, Winqist, Anna, Maltseva, Tatiana, Eriksson, Staffan, Usova, Elena, Smith, Mark, Alker, Andre, Najera, Isabel, Cammack, Nick, Martin, Joseph A., Johansson, Nils Gunnar, Smith, David B.
Published in The Journal of biological chemistry (25.01.2008)
Published in The Journal of biological chemistry (25.01.2008)
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Journal Article
Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase
Hampton, Shahienaz E., Schipani, Alessandro, Bosch-Navarrete, Cristina, Recio, Eliseo, Kaiser, Marcel, Kahnberg, Pia, González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Published in Bioorganic & medicinal chemistry (15.09.2013)
Published in Bioorganic & medicinal chemistry (15.09.2013)
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Journal Article
The Design, Synthesis, and Antiviral Activity of 4′-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4′-Azidoarabinocytidine
Smith, David B, Kalayanov, Genadiy, Sund, Christian, Winqvist, Anna, Pinho, Pedro, Maltseva, Tatiana, Morisson, Veronique, Leveque, Vincent, Rajyaguru, Sonal, Pogam, Sophie Le, Najera, Isabel, Benkestock, Kurt, Zhou, Xiao-Xiong, Maag, Hans, Cammack, Nick, Martin, Joseph A, Swallow, Steven, Johansson, Nils Gunnar, Klumpp, Klaus, Smith, Mark
Published in Journal of medicinal chemistry (08.01.2009)
Published in Journal of medicinal chemistry (08.01.2009)
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Journal Article
Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication
Nilsson, Magnus, Kalayanov, Genadiy, Winqvist, Anna, Pinho, Pedro, Sund, Christian, Zhou, Xiao-Xiong, Wähling, Horst, Belfrage, Anna-Karin, Pelcman, Michael, Agback, Tatiana, Benckestock, Kurt, Wikström, Kristina, Boothee, Mirva, Lindqvist, Anneli, Rydegård, Christina, Jonckers, Tim H.M., Vandyck, Koen, Raboisson, Pierre, Lin, Tse-I, Lachau-Durand, Sophie, de Kock, Herman, Smith, David B., Martin, Joseph A., Klumpp, Klaus, Simmen, Kenneth, Vrang, Lotta, Terelius, Ylva, Samuelsson, Bertil, Rosenquist, Åsa, Johansson, Nils Gunnar
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
Design, Synthesis, and Evaluation of 5′-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase
Hampton, Shahienaz E., Baragaña, Beatriz, Schipani, Alessandro, Bosch-Navarrete, Cristina, Musso-Buendía, J. Alexander, Recio, Eliseo, Kaiser, Marcel, Whittingham, Jean L., Roberts, Shirley M., Shevtsov, Mikhail, Brannigan, James A., Kahnberg, Pia, Brun, Reto, Wilson, Keith S., González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Published in ChemMedChem (04.10.2011)
Published in ChemMedChem (04.10.2011)
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Journal Article
Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase
Ruda, Gian Filippo, Nguyen, Corinne, Ziemkowski, Przemysław, Felczak, Krzysztof, Kasinathan, Ganasan, Musso-Buendia, Alexander, Sund, Christian, Zhou, Xiao Xiong, Kaiser, Marcel, Ruiz-Pérez, Luis M., Brun, Reto, Kulikowski, Tadeusz, Johansson, Nils Gunnar, González-Pacanowska, Dolores, Gilbert, Ian H.
Published in ChemMedChem (07.02.2011)
Published in ChemMedChem (07.02.2011)
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Journal Article
Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate
Eriksson, B, Helgstrand, E, Johansson, N G, Larsson, A, Misiorny, A, Norén, J O, Philipson, L, Stenberg, K, Stening, G, Stridh, S, Oberg, B
Published in Antimicrobial Agents and Chemotherapy (01.06.1977)
Published in Antimicrobial Agents and Chemotherapy (01.06.1977)
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