Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis
Zhang, Shaowei, Heyes, Derren J., Feng, Lingling, Sun, Wenli, Johannissen, Linus O., Liu, Huanting, Levy, Colin W., Li, Xuemei, Yang, Ji, Yu, Xiaolan, Lin, Min, Hardman, Samantha J. O., Hoeven, Robin, Sakuma, Michiyo, Hay, Sam, Leys, David, Rao, Zihe, Zhou, Aiwu, Cheng, Qi, Scrutton, Nigel S.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Journal Article
Vertebrate Cryptochromes are Vestigial Flavoproteins
Kutta, Roger J., Archipowa, Nataliya, Johannissen, Linus O., Jones, Alex R., Scrutton, Nigel S.
Published in Scientific reports (20.03.2017)
Published in Scientific reports (20.03.2017)
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Journal Article
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme
Hutton, Amy E., Foster, Jake, Crawshaw, Rebecca, Hardy, Florence J., Johannissen, Linus O., Lister, Thomas M., Gérard, Emilie F., Birch-Price, Zachary, Obexer, Richard, Hay, Sam, Green, Anthony P.
Published in Nature communications (04.03.2024)
Published in Nature communications (04.03.2024)
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Journal Article
Redox driven B12-ligand switch drives CarH photoresponse
Poddar, Harshwardhan, Rios-Santacruz, Ronald, Heyes, Derren J., Shanmugam, Muralidharan, Brookfield, Adam, Johannissen, Linus O., Levy, Colin W., Jeffreys, Laura N., Zhang, Shaowei, Sakuma, Michiyo, Colletier, Jacques-Philippe, Hay, Sam, Schirò, Giorgio, Weik, Martin, Scrutton, Nigel S., Leys, David
Published in Nature communications (21.08.2023)
Published in Nature communications (21.08.2023)
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Journal Article
Photocobilins integrate B12 and bilin photochemistry for enzyme control
Zhang, Shaowei, Jeffreys, Laura N., Poddar, Harshwardhan, Yu, Yuqi, Liu, Chuanyang, Patel, Kaylee, Johannissen, Linus O., Zhu, Lingyun, Cliff, Matthew J., Yan, Cunyu, Schirò, Giorgio, Weik, Martin, Sakuma, Michiyo, Levy, Colin W., Leys, David, Heyes, Derren J., Scrutton, Nigel S.
Published in Nature communications (28.03.2024)
Published in Nature communications (28.03.2024)
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Journal Article
Quantum Biology: An Update and Perspective
Kim, Youngchan, Bertagna, Federico, D’Souza, Edeline M., Heyes, Derren J., Johannissen, Linus O., Nery, Eveliny T., Pantelias, Antonio, Sanchez-Pedreño Jimenez, Alejandro, Slocombe, Louie, Spencer, Michael G., Al-Khalili, Jim, Engel, Gregory S., Hay, Sam, Hingley-Wilson, Suzanne M., Jeevaratnam, Kamalan, Jones, Alex R., Kattnig, Daniel R., Lewis, Rebecca, Sacchi, Marco, Scrutton, Nigel S., Silva, S. Ravi P., McFadden, Johnjoe
Published in Quantum reports (01.03.2021)
Published in Quantum reports (01.03.2021)
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Journal Article
Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase
Karuppiah, Vijaykumar, Ranaghan, Kara E, Leferink, Nicole G. H, Johannissen, Linus O, Shanmugam, Muralidharan, Ní Cheallaigh, Aisling, Bennett, Nathan J, Kearsey, Lewis J, Takano, Eriko, Gardiner, John M, van der Kamp, Marc W, Hay, Sam, Mulholland, Adrian J, Leys, David, Scrutton, Nigel S
Published in ACS catalysis (01.09.2017)
Published in ACS catalysis (01.09.2017)
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Journal Article
Identification of B cell epitopes enhanced by protein unfolding and aggregation
Eyes, Timothy J., Austerberry, James I., Dearman, Rebecca J., Johannissen, Linus O., Kimber, Ian, Smith, Noel, Thistlethwaite, Angela, Derrick, Jeremy P.
Published in Molecular immunology (01.01.2019)
Published in Molecular immunology (01.01.2019)
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Journal Article
Coupled motions direct electrons along human microsomal P450 Chains
Pudney, Christopher R, Khara, Basile, Johannissen, Linus O, Scrutton, Nigel S
Published in PLoS biology (01.12.2011)
Published in PLoS biology (01.12.2011)
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Journal Article
Atomic Description of an Enzyme Reaction Dominated by Proton Tunneling
Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus O, Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara E, Mulholland, Adrian J, Sutcliffe, Michael J, Scrutton, Nigel S, Leys, David
Published in Science (American Association for the Advancement of Science) (14.04.2006)
Published in Science (American Association for the Advancement of Science) (14.04.2006)
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Journal Article
Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems
Sutcliffe, Michael J, Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus O, Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara E, Mulholland, Adrian J, Leys, David, Scrutton, Nigel S
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (29.08.2006)
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (29.08.2006)
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Journal Article
The photochemical mechanism of a B12-dependent photoreceptor protein
Kutta, Roger J., Hardman, Samantha J. O., Johannissen, Linus O., Bellina, Bruno, Messiha, Hanan L., Ortiz-Guerrero, Juan Manuel, Elías-Arnanz, Montserrat, Padmanabhan, S., Barran, Perdita, Scrutton, Nigel S., Jones, Alex R.
Published in Nature communications (12.08.2015)
Published in Nature communications (12.08.2015)
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Journal Article
The enzyme aromatic amine dehydrogenase induces a substrate conformation crucial for promoting vibration that significantly reduces the effective potential energy barrier to proton transfer
Johannissen, Linus O, Scrutton, Nigel S, Sutcliffe, Michael J
Published in Journal of the Royal Society interface (06.12.2008)
Published in Journal of the Royal Society interface (06.12.2008)
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Journal Article
Chelator-Based Parameterization of the 12-6‑4 Lennard-Jones Molecular Mechanics Potential for More Realistic Metal Ion–Protein Interactions
Kantakevičius, Paulius, Mathiah, Calvin, Johannissen, Linus O., Hay, Sam
Published in Journal of chemical theory and computation (12.04.2022)
Published in Journal of chemical theory and computation (12.04.2022)
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Journal Article
Decoding Catalysis by Terpene Synthases
Whitehead, Joshua N., Leferink, Nicole G. H., Johannissen, Linus O., Hay, Sam, Scrutton, Nigel S.
Published in ACS catalysis (06.10.2023)
Published in ACS catalysis (06.10.2023)
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Journal Article