Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
Hitosugi, Taro, Fan, Jun, Chung, Tae-Wook, Lythgoe, Katherine, Wang, Xu, Xie, Jianxin, Ge, Qingyuan, Gu, Ting-Lei, Polakiewicz, Roberto D., Roesel, Johannes L., Chen, Georgia Z., Boggon, Titus J., Lonial, Sagar, Fu, Haian, Khuri, Fadlo R., Kang, Sumin, Chen, Jing
Published in Molecular cell (23.12.2011)
Published in Molecular cell (23.12.2011)
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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
Hitosugi, Taro, Kang, Sumin, Vander Heiden, Matthew G, Chung, Tae-Wook, Elf, Shannon, Lythgoe, Katherine, Dong, Shaozhong, Lonial, Sagar, Wang, Xu, Chen, Georgia Z, Xie, Jianxin, Gu, Ting-Lei, Polakiewicz, Roberto D, Roesel, Johannes L, Boggon, Titus J, Khuri, Fadlo R, Gilliland, D Gary, Cantley, Lewis C, Kaufman, Jonathan, Chen, Jing
Published in Science signaling (17.11.2009)
Published in Science signaling (17.11.2009)
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Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
Debiec-Rychter, Maria, Cools, Jan, Dumez, Herlinde, Sciot, Raf, Stul, Michel, Mentens, Nicole, Vranckx, Hilde, Wasag, Bartosz, Prenen, Hans, Roesel, Johannes, Hagemeijer, Anne, Van Oosterom, Allan, Marynen, Peter
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2005)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2005)
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Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain
Heidel, Florian, Solem, Fian K., Breitenbuecher, Frank, Lipka, Daniel B., Kasper, Stefan, Thiede, M.H., Brandts, Christian, Serve, Hubert, Roesel, Johannes, Giles, Francis, Feldman, Eric, Ehninger, Gerhard, Schiller, Gary J., Nimer, Stephen, Stone, Richard M., Wang, Yanfeng, Kindler, Thomas, Cohen, Pamela S., Huber, Christoph, Fischer, Thomas
Published in Blood (01.01.2006)
Published in Blood (01.01.2006)
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Fibroblast Growth Factor Receptor 3 Associates with and Tyrosine Phosphorylates p90 RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation
Kang, Sumin, Elf, Shannon, Dong, Shaozhong, Hitosugi, Taro, Lythgoe, Katherine, Guo, Ailan, Ruan, Hong, Lonial, Sagar, Khoury, Hanna J., Williams, Ifor R., Lee, Benjamin H., Roesel, Johannes L., Karsenty, Gerard, Hanauer, André, Taunton, Jack, Boggon, Titus J., Gu, Ting-Lei, Chen, Jing
Published in Molecular and Cellular Biology (01.04.2009)
Published in Molecular and Cellular Biology (01.04.2009)
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PKC412 Inhibits the Zinc Finger 198-Fibroblast Growth Factor Receptor 1 Fusion Tyrosine Kinase and Is Active in Treatment of Stem Cell Myeloproliferative Disorder
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, Duclos, Nicole, Cohen, Sarah, Adelsperger, Jennifer, Okabe, Rachel, Coburn, Allison, Galinsky, Ilene, Huntly, Brian, Cohen, Pamela S., Meyer, Thomas, Fabbro, Doriano, Roesel, Johannes, Banerji, Lolita, Griffin, James D., Xiao, Sheng, Fletcher, Jonathan A., Stone, Richard M., Gilliland, D. Gary, Witte, Owen N.
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2004)
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Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin
Barry, Elly V., Clark, Jennifer J., Cools, Jan, Roesel, Johannes, Gilliland, D. Gary
Published in Blood (15.12.2007)
Published in Blood (15.12.2007)
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[(Alkylamino)methyl]acrylophenones: Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor Protein Tyrosine Kinase
Traxler, Peter, Trinks, Uwe, Buchdunger, Elisabeth, Mett, Helmut, Meyer, Thomas, Mueller, Marcel, Regenass, Urs, Roesel, Johannes, Lydon, Nicholas
Published in Journal of medicinal chemistry (01.06.1995)
Published in Journal of medicinal chemistry (01.06.1995)
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Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy
Manley, Paul W, Caravatti, Giorgio, Furet, Pascal, Roesel, Johannes, Tran, Phi, Wagner, Trixie, Wartmann, Markus
Published in Biochemistry (Easton) (25.09.2018)
Published in Biochemistry (Easton) (25.09.2018)
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3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin : new inhibitors of HIV-1 protease. I: Fermentation, isolation and biological activity
ROGGO, B. E, PETERSEN, F, DELMENDO, R, JENNY, H.-B, PETER, H. H, ROESEL, J
Published in Journal of antibiotics (1994)
Published in Journal of antibiotics (1994)
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Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth
Peter, B, Winter, G E, Blatt, K, Bennett, K L, Stefanzl, G, Rix, U, Eisenwort, G, Hadzijusufovic, E, Gridling, M, Dutreix, C, Hoermann, G, Schwaab, J, Radia, D, Roesel, J, Manley, P W, Reiter, A, Superti-Furga, G, Valent, P
Published in Leukemia (01.02.2016)
Published in Leukemia (01.02.2016)
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Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors
Levis, Mark, Brown, Patrick, Smith, B. Douglas, Stine, Adam, Pham, Rosalyn, Stone, Richard, DeAngelo, Daniel, Galinsky, Ilene, Giles, Frank, Estey, Elihu, Kantarjian, Hagop, Cohen, Pamela, Wang, Yanfeng, Roesel, Johannes, Karp, Judith E., Small, Donald
Published in Blood (15.11.2006)
Published in Blood (15.11.2006)
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Novel Spirodihydrobenzofuranlactams as Antagonists of Endothelin and as Inhibitors of HIV-1 Protease Produced by Stachybotrys sp: I. Fermentation, Isolation and Biological Activity
ROGGO, BARBARA E., PETERSEN, FRANK, SILLS, MATTHEW, ROESEL, JOHANNES L., MOERKER, THÉOPHILE, PETER, HEINRICH H.
Published in Journal of antibiotics (1996)
Published in Journal of antibiotics (1996)
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Non-Covalent Inhibitors of the 20S Proteasome
Carlos García-Echeverría, Patricia Imbach, Johannes Roesel, Peter Fuerst, Marc Lang, Vito Guagnano, Maria Noorani, Johann Zimmermann, Pascal Furet
Published in Chimia (01.04.2003)
Published in Chimia (01.04.2003)
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Sulfonylbenzoyl-nitrostyrenes: Potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase
Traxler, Peter M, Wacker, Oskar, Bach, Ha L, Geissler, Johanna F, Kump, Wilhelm, Meyer, Thomas, Regenass, Urs, Roesel, Johannes L, Lydon, Nicholas
Published in Journal of medicinal chemistry (01.08.1991)
Published in Journal of medicinal chemistry (01.08.1991)
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Aromatic Interactions with Phenylalanine 691 and Cysteine 828: A Concept for FMS-like Tyrosine Kinase-3 Inhibition. Application to the Discovery of a New Class of Potential Antileukemia Agents
Furet, Pascal, Bold, Guido, Meyer, Thomas, Roesel, Johannes, Guagnano, Vito
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
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The Midostaurin (PKC412) Metabolite CGP52421 Shows Little Growth-Inhibitory Activity Against Against Neoplastic Mast Cells but Retains Inhibitory Effects on IgE-Dependent Activation and Histamine Release
Peter, Barbara, Blatt, Katharina, Stefanzl, Gabriele, Hadzijusufovic, Emir, Dutreix, Catherine, Gross, Stefan H, Roesel, Johannes L, Valent, Peter
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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