Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
Wang, Yun, Zhang, Kelvin, Georgiev, Peter, Wells, Steven, Xu, Haiyan, Lacey, Brian M, Xu, Zangwei, Laskey, Jason, Mcleod, Robbie, Methot, Joey L, Bittinger, Mark, Pasternak, Alexander, Ranganath, Sheila
Published in PloS one (03.12.2020)
Published in PloS one (03.12.2020)
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SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
METHOT, Joey L, HAMBLETT, Christopher L, HONGMEI WANG, KRAL, Astrid M, OZEROVA, Nicole, CRUZ, Jonathan C, HAINES, Brian, CHENARD, Melissa, KENIFIC, Candia M, SECRIST, J. Paul, MILLER, Thomas A, MAMPREIAN, Dawn M, JUNG, Joon, HARSCH, Andreas, SZEWCZAK, Alexander A, DAHLBERG, William K, MIDDLETON, Richard E, HUGHES, Bethany, FLEMING, Judith C
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry
Wen, Xiujuan, Liu, Chang, Tovar, Kiersten, Curran, Patrick, Richards, Matthew, Agrawal, Sony, Johnstone, Richard, Loy, Ryan E., Methot, Joey L., Mansueto, My Sam, Koglin, Markus, Wildey, Mary Jo, Burton, Lyle, Covey, Thomas R., Bateman, Kevin P., Kavana, Michael, McLaren, David G.
Published in Journal of the American Chemical Society (24.07.2024)
Published in Journal of the American Chemical Society (24.07.2024)
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Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Identification of Potent Reverse Indazole Inhibitors for HPK1
Yu, Elsie C, Methot, Joey L, Fradera, Xavier, Lesburg, Charles A, Lacey, Brian M, Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M, Xu, Zangwei, Piesvaux, Jennifer A, Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators
Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors
Zhou, Hua, McGowan, Meredeth A., Lipford, Kathryn, Christopher, Matthew, Fradera, Xavier, Witter, David, Lesburg, Charles A., Li, Chaomin, Methot, Joey L., Lampe, John, Achab, Abdelghani, Shaffer, Lynsey, Goldenblatt, Peter, Shah, Sanjiv, Bass, Alan, Schroeder, Gottfried, Chen, Dapeng, Zeng, Haoyu, Augustin, Martin A., Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (01.01.2020)
Published in Bioorganic & medicinal chemistry letters (01.01.2020)
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Discovery of a new series of PI3K-δ inhibitors from Virtual Screening
Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds
Vara, Brandon A, Levi, Samuel M, Achab, Abdelghani, Candito, David A, Fradera, Xavier, Lesburg, Charles A, Kawamura, Shuhei, Lacey, Brian M, Lim, Jongwon, Methot, Joey L, Xu, Zangwei, Xu, Haiyan, Smith, Dustin M, Piesvaux, Jennifer A, Miller, J. Richard, Bittinger, Mark, Ranganath, Sheila H, Bennett, David J, DiMauro, Erin F, Pasternak, Alexander
Published in ACS medicinal chemistry letters (08.04.2021)
Published in ACS medicinal chemistry letters (08.04.2021)
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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability
Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Discovery of 1‑(1H‑Pyrazolo[4,3‑c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers
Lim, Jongwon, Kelley, Elizabeth H, Methot, Joey L, Zhou, Hua, Petrocchi, Alessia, Chen, Hongmin, Hill, Susan E, Hinton, Marlene C, Hruza, Alan, Jung, Joon O, Maclean, John K. F, Mansueto, My, Naumov, George N, Philippar, Ulrike, Raut, Shruti, Spacciapoli, Peter, Sun, Dongyu, Siliphaivanh, Phieng
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580]
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities
Newbold, Andrea, Matthews, Geoffrey M, Bots, Michael, Cluse, Leonie A, Clarke, Christopher J P, Banks, Kellie-Marie, Cullinane, Carleen, Bolden, Jessica E, Christiansen, Ailsa J, Dickins, Ross A, Miccolo, Claudia, Chiocca, Susanna, Kral, Astrid M, Ozerova, Nicole D, Miller, Thomas A, Methot, Joey L, Richon, Victoria M, Secrist, J Paul, Minucci, Saverio, Johnstone, Ricky W
Published in Molecular cancer therapeutics (01.12.2013)
Published in Molecular cancer therapeutics (01.12.2013)
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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael
Published in MedChemComm (21.07.2021)
Published in MedChemComm (21.07.2021)
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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
Lacey, Brian M., Xu, Zangwei, Chai, Xiaomei, Laskey, Jason, Fradera, Xavier, Mittal, Payal, Mishra, Sasmita, Piesvaux, Jennifer, Saradjian, Peter, Shaffer, Lynsey, Vassileva, Galya, Gerdt, Catherine, Wang, Yun, Ferguson, Heidi, Smith, Dustin M., Ballard, Jeanine, Wells, Steven, Jain, Rishabh, Mueller, Uwe, Addona, George, Kariv, Ilona, Methot, Joey L., Bittinger, Mark, Ranganath, Sheila, Mcleod, Robbie, Pasternak, Alexander, Miller, J. Richard, Xu, Haiyan
Published in SLAS discovery (01.01.2021)
Published in SLAS discovery (01.01.2021)
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