Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
Uversky, Vladimir N, Davé, Vrushank, Iakoucheva, Lilia M, Malaney, Prerna, Metallo, Steven J, Pathak, Ravi Ramesh, Joerger, Andreas C
Published in Chemical reviews (09.07.2014)
Published in Chemical reviews (09.07.2014)
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Journal Article
Design of a molecular support for cryo-EM structure determination
Martin, Thomas G., Bharat, Tanmay A. M., Joerger, Andreas C., Bai, Xiao-chen, Praetorius, Florian, Fersht, Alan R., Dietz, Hendrik, Scheres, Sjors H. W.
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
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Journal Article
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Boeckler, Frank M, Joerger, Andreas C, Jaggi, Gaurav, Rutherford, Trevor J, Veprintsev, Dmitry B, Fersht, Alan R
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2008)
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Journal Article
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Balourdas, Dimitrios-Ilias, Markl, Anja M., Krämer, Andreas, Settanni, Giovanni, Joerger, Andreas C.
Published in Cell death & disease (11.06.2024)
Published in Cell death & disease (11.06.2024)
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Journal Article
Tracing the Evolution of the p53 Tetramerization Domain
Joerger, Andreas C., Wilcken, Rainer, Andreeva, Antonina
Published in Structure (London) (02.09.2014)
Published in Structure (London) (02.09.2014)
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Journal Article
Structural insights into a regulatory mechanism of FIR RRM1-FUSE interaction
Ni, Xiaomin, Joerger, Andreas C, Chaikuad, Apirat, Knapp, Stefan
Published in Open biology (31.05.2023)
Published in Open biology (31.05.2023)
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Journal Article
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53
Joerger, Andreas C., Bauer, Matthias R., Wilcken, Rainer, Baud, Matthias G.J., Harbrecht, Hannes, Exner, Thomas E., Boeckler, Frank M., Spencer, John, Fersht, Alan R.
Published in Structure (London) (01.12.2015)
Published in Structure (London) (01.12.2015)
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Journal Article
Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs
Bauer, Matthias R, Jones, Rhiannon N, Baud, Matthias G. J, Wilcken, Rainer, Boeckler, Frank M, Fersht, Alan R, Joerger, Andreas C, Spencer, John
Published in ACS chemical biology (19.08.2016)
Published in ACS chemical biology (19.08.2016)
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Journal Article
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
Zhang, Qiang, Balourdas, Dimitrios-Ilias, Baron, Bruno, Senitzki, Alon, Haran, Tali E., Wiman, Klas G., Soussi, Thierry, Joerger, Andreas C.
Published in Cell death & disease (07.03.2022)
Published in Cell death & disease (07.03.2022)
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Journal Article
Structural Evolution of p53, p63, and p73: Implication for Heterotetramer Formation
Joerger, Andreas C., Rajagopalan, Sridharan, Natan, Eviatar, Veprintsev, Dmitry B., Robinson, Carol V., Fersht, Alan R.
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2009)
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Journal Article
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration
Arbely, Eyal, Natan, Eviatar, Brandt, Tobias, Allen, Mark D., Veprintsev, Dmitry B., Robinson, Carol V., Chin, Jason W., Joerger, Andreas C., Fersht, Alan R.
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
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Journal Article
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2
Vogel, Simon M, Bauer, Matthias R, Joerger, Andreas C, Wilcken, Rainer, Brandt, Tobias, Veprintsev, Dmitry B, Rutherford, Trevor J, Fersht, Alan R, Boeckler, Frank M
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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Journal Article
Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells
Luparello, Claudio, Cruciata, Ilenia, Joerger, Andreas C, Ocasio, Cory A, Jones, Rhiannon, Tareque, Raysa Khan, Bagley, Mark C, Spencer, John, Walker, Martin, Austin, Carol, Ferrara, Tiziana, D Oca, Pietro, Bellina, Rossella, Branni, Rossella, Caradonna, Fabio
Published in International journal of molecular sciences (26.03.2021)
Published in International journal of molecular sciences (26.03.2021)
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Journal Article
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
Wanior, Marek, Krämer, Andreas, Knapp, Stefan, Joerger, Andreas C.
Published in Oncogene (27.05.2021)
Published in Oncogene (27.05.2021)
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Journal Article