Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11
Jo, Ukhyun, Murai, Yasuhisa, Takebe, Naoko, Thomas, Anish, Pommier, Yves
Published in Cancers (14.09.2021)
Published in Cancers (14.09.2021)
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Journal Article
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
Murai, Junko, Zhang, Hongliang, Pongor, Lorinc, Tang, Sai-Wen, Jo, Ukhyun, Moribe, Fumiya, Ma, Yixiao, Tomita, Masaru, Pommier, Yves
Published in Cell reports (Cambridge) (24.03.2020)
Published in Cell reports (Cambridge) (24.03.2020)
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Journal Article
SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243
Murai, Yasuhisa, Jo, Ukhyun, Murai, Junko, Jenkins, Lisa, Huang, Shar-Yin N, Chakka, Sirisha, Chen, Lu, Cheng, Ken, Fukuda, Shinsaku, Takebe, Naoko, Pommier, Yves
Published in Cancer research (Chicago, Ill.) (01.06.2021)
Published in Cancer research (Chicago, Ill.) (01.06.2021)
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Journal Article
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes
Saha, Liton Kumar, Saha, Sourav, Yang, Xi, Huang, Shar-yin Naomi, Sun, Yilun, Jo, Ukhyun, Pommier, Yves
Published in Nature communications (06.04.2023)
Published in Nature communications (06.04.2023)
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Journal Article
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment
Kang, Jinho, Choi, Yoon Ji, Seo, Bo Yeon, Jo, Ukhyun, Park, Serk In, Kim, Yeul Hong, Park, Kyong Hwa
Published in Scientific reports (19.06.2019)
Published in Scientific reports (19.06.2019)
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Journal Article
PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress
Jo, Ukhyun, Cai, Winson, Wang, Jingming, Kwon, Yoojin, D'Andrea, Alan D, Kim, Hyungjin
Published in PLoS genetics (01.12.2016)
Published in PLoS genetics (01.12.2016)
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Journal Article
Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway
Wang, Jingming, Chan, Bryan, Tong, Michael, Paung, YiTing, Jo, Ukhyun, Martin, Dwight, Seeliger, Markus, Haley, John, Kim, Hyungjin
Published in PLoS genetics (21.02.2019)
Published in PLoS genetics (21.02.2019)
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Journal Article
Posttranslational regulation of Akt in human cancer
Chan, Chia-Hsin, Jo, Ukhyun, Kohrman, Abraham, Rezaeian, Abdol Hossein, Chou, Ping-Chieh, Logothetis, Christopher, Lin, Hui-Kuan
Published in Cell & bioscience (01.10.2014)
Published in Cell & bioscience (01.10.2014)
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Journal Article
Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation
Pongor, Lorinc S., Tlemsani, Camille, Elloumi, Fathi, Arakawa, Yasuhiro, Jo, Ukhyun, Gross, Jacob M., Mosavarpour, Sara, Varma, Sudhir, Kollipara, Rahul K., Roper, Nitin, Teicher, Beverly A., Aladjem, Mirit I., Reinhold, William, Thomas, Anish, Minna, John D., Johnson, Jane E., Pommier, Yves
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Journal Article
Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C
Whang, Young Mi, Jo, Ukhyun, Sung, Jae Sook, Ju, Hyun Jung, Kim, Hyun Kyung, Park, Kyong Hwa, Lee, Jong Won, Koh, In Song, Kim, Yeul Hong
Published in PloS one (21.01.2013)
Published in PloS one (21.01.2013)
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Journal Article
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways
Sun, Yilun, Saha, Liton Kumar, Saha, Sourav, Jo, Ukhyun, Pommier, Yves
Published in DNA repair (01.10.2020)
Published in DNA repair (01.10.2020)
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Journal Article
Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Jo, Ukhyun, Senatorov, Ilya S, Zimmermann, Astrid, Saha, Liton Kumar, Murai, Yasuhisa, Kim, Se Hyun, Rajapakse, Vinodh N, Elloumi, Fathi, Takahashi, Nobuyuki, Schultz, Christopher W, Thomas, Anish, Zenke, Frank T, Pommier, Yves
Published in Molecular cancer therapeutics (01.08.2021)
Published in Molecular cancer therapeutics (01.08.2021)
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Journal Article
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
Jo, Ukhyun, Murai, Yasuhisa, Chakka, Sirisha, Chen, Lu, Cheng, Ken, Murai, Junko, Saha, Liton Kumar, Jenkins, Lisa M. Miller, Pommier, Yves
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2021)
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Journal Article
The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Jo, Ukhyun, Arakawa, Yasuhiro, Zimmermann, Astrid, Taniyama, Daiki, Mizunuma, Makito, Jenkins, Lisa M., Maity, Tapan K., Kumar, Suresh, Zenke, Frank T., Takebe, Naoko, Pommier, Yves
Published in Molecular cancer therapeutics (02.07.2024)
Published in Molecular cancer therapeutics (02.07.2024)
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