Search Results - "Jing, Lanlan" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation

by Zongji Zhuo, Wang, Zhao, Lanlan Jing, Zhang, Tao, Ge, Anchao, Zhou, Zhenzhen, Liu, Ying, Li, Xin, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in International journal of molecular sciences (01.08.2024)

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Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

by Jiang, Xiangyi, Wu, Gaochan, Zalloum, Waleed A, Meuser, Megan E, Dick, Alexej, Sun, Lin, Chen, Chin-Ho, Kang, Dongwei, Jing, Lanlan, Jia, Ruifang, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Published in RSC advances (2019)

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Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening

Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening

by Jiang, Xiangyi, Li, Jing, Viayna, Antonio, Luque, F. Javier, Woodson, Molly, Jing, Lanlan, Gao, Shenghua, Zhao, Fabao, Xie, Minghui, Toth, Karoly, Tavis, John, Tollefson, Ann E., Liu, Xinyong, Zhan, Peng
Published in MedChemComm (18.10.2023)

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Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

by Gao, Shenghua, Song, Letian, Xu, Hongtao, Fikatas, Antonios, Oeyen, Merel, De Jonghe, Steven, Zhao, Fabao, Jing, Lanlan, Jochmans, Dirk, Vangeel, Laura, Cheng, Yusen, Kang, Dongwei, Neyts, Johan, Herdewijn, Piet, Schols, Dominique, Zhan, Peng, Liu, Xinyong
Published in Molecules (Basel, Switzerland) (25.12.2022)

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Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

by Kang, Dongwei, Zhao, Tong, Wang, Zhao, Feng, Da, Zhang, Heng, Huang, Boshi, Wu, Gaochan, Wei, Fenju, Zhou, Zhongxia, Jing, Lanlan, Zuo, Xiaofang, Tian, Ye, Poongavanam, Vasanthanathan, Kongsted, Jacob, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Communications chemistry (28.06.2019)

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Recent applications of click chemistry in drug discovery

Recent applications of click chemistry in drug discovery

by Jiang, Xiangyi, Hao, Xia, Jing, Lanlan, Wu, Gaochan, Kang, Dongwei, Liu, Xinyong, Zhan, Peng
Published in Expert opinion on drug discovery (03.08.2019)

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Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors

Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors

by Jing, Lanlan, Wu, Gaochan, Kang, Dongwei, Zhou, Zhongxia, Song, Yuning, Liu, Xinyong, Zhan, Peng
Published in Drug discovery today (01.02.2019)

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Fsp3: A new parameter for drug-likeness

Fsp3: A new parameter for drug-likeness

by Wei, Wenxiu, Cherukupalli, Srinivasulu, Jing, Lanlan, Liu, Xinyong, Zhan, Peng
Published in Drug discovery today (01.10.2020)

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Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships exploration

Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships exploration

by Zhang, Heng, Li, Jing, Toth, Karoly, Tollefson, Ann E., Jing, Lanlan, Gao, Shenghua, Liu, Xinyong, Zhan, Peng
Published in Bioorganic & medicinal chemistry (15.12.2023)

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2,4,5-Trisubstituted Pyrimidines as Potent HIV‑1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies

2,4,5-Trisubstituted Pyrimidines as Potent HIV‑1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies

by Kang, Dongwei, Ruiz, Francesc X, Sun, Yanying, Feng, Da, Jing, Lanlan, Wang, Zhao, Zhang, Tao, Gao, Shenghua, Sun, Lin, De Clercq, Erik, Pannecouque, Christophe, Arnold, Eddy, Zhan, Peng, Liu, Xinyong
Published in Journal of medicinal chemistry (08.04.2021)

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Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization

Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization

by Jing, Lanlan, Wu, Gaochan, Zhao, Fabao, Jiang, Xiangyi, Liu, Na, feng, Da, Sun, Yanying, Zhang, Tao, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Liu, Xinyong, Zhan, Peng
Published in European journal of medicinal chemistry (05.11.2024)

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Development of Novel Dihydrofuro[3,4‑d]pyrimidine Derivatives as HIV‑1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C

Development of Novel Dihydrofuro[3,4‑d]pyrimidine Derivatives as HIV‑1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C

by Kang, Dongwei, Sun, Yanying, Feng, Da, Gao, Shenghua, Wang, Zhao, Jing, Lanlan, Zhang, Tao, Jiang, Xiangyi, Lin, Hao, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Journal of medicinal chemistry (10.02.2022)

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Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV‑2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV‑2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

by Gao, Shenghua, Sylvester, Katharina, Song, Letian, Claff, Tobias, Jing, Lanlan, Woodson, Molly, Weiße, Renato H., Cheng, Yusen, Schäkel, Laura, Petry, Marvin, Gütschow, Michael, Schiedel, Anke C., Sträter, Norbert, Kang, Dongwei, Xu, Shujing, Toth, Karoly, Tavis, John, Tollefson, Ann E., Müller, Christa E., Liu, Xinyong, Zhan, Peng
Published in Journal of medicinal chemistry (13.10.2022)

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In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

by Kang, Dongwei, Feng, Da, Jing, Lanlan, Sun, Yanying, Wei, Fenju, Jiang, Xiangyi, Wu, Gaochan, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in European journal of medicinal chemistry (01.05.2020)

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Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene3,2-dpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene3,2-dpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation

by Zhuo, Zongji, Wang, Zhao, Jing, Lanlan, Zhang, Tao, Ge, Anchao, Zhou, Zhenzhen, Liu, Ying, Li, Xin, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in International journal of molecular sciences (20.08.2024)

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Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV‑1 NNRTIs

Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV‑1 NNRTIs

by Sun, Yanying, Zhou, Zhenzhen, Feng, Da, Jing, Lanlan, Zhao, Fabao, Wang, Zhao, Zhang, Tao, Lin, Hao, Song, Hao, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in Journal of medicinal chemistry (08.12.2022)

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Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV‑2 Main Protease Inhibitors

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV‑2 Main Protease Inhibitors

by Gao, Shenghua, Song, Letian, Claff, Tobias, Woodson, Molly, Sylvester, Katharina, Jing, Lanlan, Weiße, Renato H., Cheng, Yusen, Sträter, Norbert, Schäkel, Laura, Gütschow, Michael, Ye, Bing, Yang, Mianling, Zhang, Tao, Kang, Dongwei, Toth, Karoly, Tavis, John, Tollefson, Ann E., Müller, Christa E., Zhan, Peng, Liu, Xinyong
Published in Journal of medicinal chemistry (22.12.2022)

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Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

by Wei, Wenxiu, Jing, Lanlan, Tian, Ye, Wieckowska, Anna, Kang, Dongwei, Meng, Bairu, Panek, Dawid, Godyn, Justyna, Goral, Izabella, Song, Yuning, Liu, Xinyong, Zhan, Peng
Published in Bioorganic & medicinal chemistry (15.12.2023)

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Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

by Feng, Da, Zuo, Xiaofang, Jing, Lanlan, Chen, Chin-Ho, Olotu, Fisayo A., Lin, Hao, Soliman, Mahmoud, De Clercq, Erik, Pannecouque, Christophe, Lee, Kuo-Hsiung, Kang, Dongwei, Liu, Xinyong, Zhan, Peng
Published in European journal of medicinal chemistry (05.02.2021)

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Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries

Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries

by Tao, Yucen, Hao, Xia, Jing, Lanlan, Sun, Lin, Cherukupalli, Srinivasulu, Liu, Shugong, Wu, Gaochan, Xu, Shujing, Zhang, Xujie, Shi, Xiaoyu, Song, Yuning, Liu, Xinyong, Zhan, Peng
Published in Bioorganic chemistry (01.10.2021)

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