Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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A Trimer of Dimers Is the Basic Building Block for Human Immunodeficiency Virus-1 Capsid Assembly
Tsiang, Manuel, Niedziela-Majka, Anita, Hung, Magdeleine, Jin, Debi, Hu, Eric, Yant, Stephen, Samuel, Dharmaraj, Liu, Xiaohong, Sakowicz, Roman
Published in Biochemistry (Easton) (05.06.2012)
Published in Biochemistry (Easton) (05.06.2012)
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Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug
FENG, Joy Y, GUOFENG CHENG, YANG TIAN, LEE, Yu-Jen, STEPAN, George, LAGPACAN, Leanna L, DEBI JIN, HUNG, Magdeleine, KU, Karin S, BIN HAN, KITRINOS, Kathryn, PERRON, Michel, PERRY, Jason, BIRKUS, Gabriel, WONG, Kelly A, WEIDONG ZHONG, KIM, Choung U, CAREY, Anne, AESOP CHO, RAY, Adrian S, BARAUSKAS, Ona, YILI XU, FENAUX, Martijn, ENG, Stacey, TIRUNAGARI, Neeraj, BETTY PENG, MEI YU
Published in Antimicrobial agents and chemotherapy (01.04.2014)
Published in Antimicrobial agents and chemotherapy (01.04.2014)
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Large-scale functional purification of recombinant HIV-1 capsid
Hung, Magdeleine, Niedziela-Majka, Anita, Jin, Debi, Wong, Melanie, Leavitt, Stephanie, Brendza, Katherine M, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (05.03.2013)
Published in PloS one (05.03.2013)
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Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly
Lad, Latesh, Clancy, Sheila, Koditek, David, Wong, Melanie H, Jin, Debi, Niedziela-Majka, Anita, Papalia, Giuseppe A, Hung, Magdeleine, Yant, Stephen, Somoza, John R, Hu, Eric, Chou, Chienhung, Tse, Winston, Halcomb, Randall, Sakowicz, Roman, Pagratis, Nikos
Published in Biochemistry (Easton) (07.04.2015)
Published in Biochemistry (Easton) (07.04.2015)
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Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design
Lansdon, Eric B, Brendza, Katherine M, Hung, Magdeleine, Wang, Ruth, Mukund, Susmith, Jin, Debi, Birkus, Gabriel, Kutty, Nilima, Liu, Xiaohong
Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Yant, Stephen R, Mulato, Andrew, Hansen, Derek, Tse, Winston C, Niedziela-Majka, Anita, Zhang, Jennifer R, Stepan, George J, Jin, Debi, Wong, Melanie H, Perreira, Jill M, Singer, Eric, Papalia, Giuseppe A, Hu, Eric Y, Zheng, Jim, Lu, Bing, Schroeder, Scott D, Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R, Hung, Magdeleine, McDougall, William M, Brass, Abraham L, Sundquist, Wesley I, Cihlar, Tomas, Link, John O
Published in Nature medicine (01.09.2019)
Published in Nature medicine (01.09.2019)
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Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques
Boopathy, Archana Vidya, Nekkalapudi, Anurag, Sung, Janette, Schulha, Sophie, Jin, Debi, Sharma, Bhawna, Ng, Sarah, Lu, Sabrina, Wimmer, Raphaela, Suthram, Silpa, Ahmadi-Erber, Sarah, Lauterbach, Henning, Orlinger, Klaus K, Hung, Magdeleine, Carr, Brian, Callebaut, Christian, Geleziunas, Romas, Kuhne, Michelle, Schmidt, Sarah, Falkard, Brie
Published in Journal of virology (23.07.2024)
Published in Journal of virology (23.07.2024)
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Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Sperandio, David, Aktoudianakis, Vangelis, Babaoglu, Kerim, Chen, Xiaowu, Elbel, Kristyna, Chin, Gregory, Corkey, Britton, Du, Jinfa, Jiang, Bob, Kobayashi, Tetsuya, Mackman, Richard, Martinez, Ruben, Yang, Hai, Zablocki, Jeff, Kusam, Saritha, Jordan, Kim, Webb, Heather, Bates, Jamie G., Lad, Latesh, Mish, Michael, Niedziela-Majka, Anita, Metobo, Sammy, Sapre, Annapurna, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Kan, Elaine, Eisenberg, Gene, Larson, Nate, Newby, Zachary E.R., Lansdon, Eric, Tay, Chin, Neve, Richard M., Shevick, Sophia L., Breckenridge, David G.
Published in Bioorganic & medicinal chemistry (01.02.2019)
Published in Bioorganic & medicinal chemistry (01.02.2019)
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Combination Therapy of Selective MMP9 Inhibitor and JAK Inhibitor Is Effective to Induce Disease Control in Mouse DSS Model of Colitis: 593
Kim, Sunhwa, Carr, Brian, Tong, Leah, Sobczyk, Monika, Zheng, Jim, Lu, Bing, Mikaelian, Igor, Brockett, Robert, Jin, Debi, Wang, Ruth, Kanwar, Bittoo, Smith, Victoria
Published in The American journal of gastroenterology (01.10.2016)
Published in The American journal of gastroenterology (01.10.2016)
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Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir
Barauskas, Ona, Corsa, Amoreena C., Wang, Ruth, Hluhanich, Scott, Jin, Debi, Hung, Magdeleine, Yang, Huiling, Delaney, William E., Schultz, Brian E.
Published in Biochimica et biophysica acta (01.12.2014)
Published in Biochimica et biophysica acta (01.12.2014)
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Dithiothreitol Causes HIV-1 Integrase Dimer Dissociation While Agents Interacting With the Integrase Dimer Interface Promote Dimer Formation
Tsiang, Manuel, Jones, Gregg S, Hung, Magdeleine, Samuel, Dharmaraj, Novikov, Nikolai, Mukund, Susmith, Brendza, Katherine M, Niedziela-Majka, Anita, Jin, Debi, Liu, Xiaohong, Mitchell, Michael, Sakowicz, Roman, Geleziunas, Romas
Published in Biochemistry (Easton) (15.03.2011)
Published in Biochemistry (Easton) (15.03.2011)
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Lipid Sensing Apolipoprotein A-I for Novel High-Throughput Lipidation Assays
Niedziela-Majka, Anita, Lad, Latesh, Chishom, Jeffrey W., Lagpacan, Leanna, Schwartz, Karen, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Brendza, Katherine M., Liu, Xioahong, Pagratis, Nikos, Sakowicz, Roman
Published in Biophysical journal (14.02.2012)
Published in Biophysical journal (14.02.2012)
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Lipid-sensing high-throughput ApoA-I assays
Niedziela-Majka, Anita, Lad, Latesh, Chisholm, Jeffrey W, Lagpacan, Leanna, Schwartz, Karen, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Brendza, Katherine M, Liu, Xiaohong, Pagratis, Nikos, Sakowicz, Roman
Published in Journal of biomolecular screening (01.09.2012)
Published in Journal of biomolecular screening (01.09.2012)
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Large-Scale Functional Purification of Recombinant HIV-1 Capsid. e58035
Hung, Magdeleine, Niedziela-Majka, Anita, Jin, Debi, Wong, Melanie, Leavitt, Stephanie, Brendza, Katherine M, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (01.03.2013)
Published in PloS one (01.03.2013)
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