[¹⁸F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
Burns, H. Donald, Van Laere, Koen, Sanabria-Bohórquez, Sandra, Hamill, Terence G, Bormans, Guy, Eng, Wai-si, Gibson, Ray, Ryan, Christine, Connolly, Brett, Patel, Shil, Krause, Stephen, Vanko, Amy, Van Hecken, Anne, Dupont, Patrick, De Lepeleire, Inge, Rothenberg, Paul, Stoch, S. Aubrey, Cote, Josee, Hagmann, William K, Jewell, James P, Lin, Linus S, Liu, Ping, Goulet, Mark T, Gottesdiener, Keith, Wagner, John A, de Hoon, Jan, Mortelmans, Luc, Fong, Tung M, Hargreaves, Richard J
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2007)
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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
Sebhat, Iyassu K, Franklin, Christopher, Lo, Michael M.-C, Chen, David, Jewell, James P, Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Guan, Xiao-Ming, Marsh, Donald J, Kosinski, Jennifer A, Metzger, Joseph M, Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R, Henderson, Alan J, Reitman, Marc L, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S
Published in ACS medicinal chemistry letters (13.01.2011)
Published in ACS medicinal chemistry letters (13.01.2011)
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Synthesis and evaluation of N-[(1 S,2 S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists
Du, Wu, Jewell, James P., Lin, Linus S., Colandrea, Vincent J., Xiao, Jing C., Lao, Julie, Shen, Chun-Pyn, Bateman, Thomas J., Reddy, Vijay B.G., Ha, Sookhee N., Shah, Shrenik K., Fong, Tung M., Hale, Jeffrey J., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors
Katz, Jason D., Haidle, Andrew, Childers, Kaleen K., Zabierek, Anna A., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Su, Hua-Poo, Munshi, Sanjeev, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
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MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
PAN, Bo-Sheng, CHAN, Grace K. Y, JEWELL, James P, KARIV, Ilona, KATZ, Jason D, KUNII, Kaiko, WEI LU, LUTTERBACH, Bart A, PAWELETZ, Cloud P, XIANLU QU, REILLY, John F, SZEWCZAK, Alexander A, CHENARD, Melissa, QINWEN ZENG, KOHL, Nancy E, DINSMORE, Christopher J, CHI, An, DAVIS, Lenora J, DESHMUKH, Sujal V, GIBBS, Jackson B, GIL, Susana, GAOZHEN HANG, HATCH, Harold
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Discovery of a 5H-Benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer
Katz, Jason D, Jewell, James P, Guerin, David J, Lim, Jongwon, Dinsmore, Christopher J, Deshmukh, Sujal V, Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D, Dahlberg, William K, Davis, Lenora, Falcone, Danielle, Gabarda, Ana E, Hang, Gaozhen, Hatch, Harold, Holmes, Rachael, Kunii, Kaiko, Lumb, Kevin J, Lutterbach, Bart, Mathvink, Robert, Nazef, Naim, Patel, Sangita B, Qu, Xianlu, Reilly, John F, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Spencer, Kerrie B, Szewczak, Alexander A, Walker, Deborah, Wang, Wenxian, Young, Jonathan, Zeng, Qinwen
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation
Haidle, Andrew M., Childers, Kaleen K., Zabierek, Anna A., Katz, Jason D., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
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Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents
Fong, Tung M., Guan, Xiao-Ming, Marsh, Donald J., Shen, Chun-Pyn, Stribling, D. Sloan, Rosko, Kim M., Lao, Julie, Yu, Hong, Feng, Yue, Xiao, Jing C., Van der Ploeg, Lex H. T., Goulet, Mark T., Hagmann, Williams K., Lin, Linus S., Lanza, Thomas J., Jewell, James P., Liu, Ping, Shah, Shrenik K., Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S., Francis, Barbara, Strack, Alison M., MacIntyre, D. Euan, Shearman, Lauren P.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
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Similar in vitro pharmacology of human cannabinoid CB1 receptor variants expressed in CHO cells
Xiao, Jing Chen, Jewell, James P, Lin, Linus S, Hagmann, William K, Fong, Tung M, Shen, Chun-Pyn
Published in Brain research (31.10.2008)
Published in Brain research (31.10.2008)
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Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant
Kopka, Ihor E., Lin, Linus S., Jewell, James P., Lanza, Thomas J., Fong, Tung M., Shen, Chun-Pyn, Lao, Zhege J., Ha, Sookhee, Castonguay, Laurie G., Van der Ploeg, Lex, Goulet, Mark T., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity
Lin, Linus S, Lanza, Thomas J, Jewell, James P, Liu, Ping, Shah, Shrenik K, Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Xiao, Jing Chen, Shearman, Lauren P, Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Marsh, Donald J, Feng, Yue, Kumar, Sanjeev, Samuel, Koppara, Yin, Wenji, Van der Ploeg, Lex H. T, Goulet, Mark T, Hagmann, William K
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
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Discovery of N-{(1S,2S)-2-(3-Cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a Cannabinoid-1 Receptor Positron Emission Tomography Tracer Suitable for Clinical Use
Liu, Ping, Lin, Linus S, Hamill, Terence G, Jewell, James P, Lanza, Thomas J, Gibson, Raymond E, Krause, Stephen M, Ryan, Christine, Eng, Waisi, Sanabria, Sandra, Tong, Xinchun, Wang, Junying, Levorse, Dorothy A, Owens, Karen A, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Kumar, Sanjeev, Yin, Wenji, Payack, Joseph F, Springfield, Shawn A, Hargreaves, Richard, Burns, H. Donald, Goulet, Mark T, Hagmann, William K
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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Discovery of N-{N-[(3-Cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(l)-prolyl}-4-[(3′,5′-dichloroisonicotinoyl)amino]-(l)-phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4
Lin, Linus S, Lanza, Thomas, Jewell, James P, Liu, Ping, Jones, Carrie, Kieczykowski, Gerard R, Treonze, Kelly, Si, Qian, Manior, Salony, Koo, Gloria, Tong, Xinchun, Wang, Junying, Schuelke, Anne, Pivnichny, James, Wang, Regina, Raab, Conrad, Vincent, Stella, Davies, Philip, MacCoss, Malcolm, Mumford, Richard A, Hagmann, William K
Published in Journal of medicinal chemistry (11.06.2009)
Published in Journal of medicinal chemistry (11.06.2009)
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Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques
Samuel, Koppara, Yin, Wenji, Stearns, Ralph A., Tang, Yui S., Chaudhary, Ashok G., Jewell, James P., Lanza Jr, Thomas, Lin, Linus S., Hagmann, William K., Evans, David C., Kumar, Sanjeev
Published in Journal of mass spectrometry. (01.02.2003)
Published in Journal of mass spectrometry. (01.02.2003)
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Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists
Armstrong, Helen E., Galka, Amy, Lin, Linus S., Lanza, Thomas J., Jewell, James P., Shah, Shrenik K., Guthikonda, Ravi, Truong, Quang, Chang, Linda L., Quaker, Grace, Colandrea, Vincent J., Tong, Xinchun, Wang, Junying, Xu, Sherry, Fong, Tung M., Shen, Chun-Pyn, Lao, Julie, Chen, Jing, Shearman, Lauren P., Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Ha, Sookhee, der Ploeg, Lex Van, Goulet, Mark T., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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STING 효능제로서의 벤조티오펜 및 관련 화합물
CASH BRANDON D, CUMMING JARED N, JEWELL JAMES P, LARSEN MATTHEW A, DEMONG DUANE E, ALTMAN MICHAEL D, LIM JONGWON, HENDERSON TIMOTHY J, LU MIN, CHILDERS MATTHEW LLOYD, OTTE RYAN D, HAIDLE ANDREW MARC, TROTTER BENJAMIN WESLEY
Year of Publication 11.12.2020
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STING - CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
CUMMING JARED N, JEWELL JAMES P, TRUONG QUANG T, ALTMAN MICHAEL D, LIM JONGWON, HENDERSON TIMOTHY J, WALSH SHAWN P, LU MIN, CHANG WONSUK, LIANG RUI, CHILDERS MATTHEW LLOYD, LIU HONG, OTTE RYAN D, SIU TONY, ANDRESEN BRIAN, HAIDLE ANDREW MARC, NORTHRUP ALAN B, ZHAO KAKE, TROTTER BENJAMIN WESLEY
Year of Publication 12.10.2020
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Year of Publication 12.10.2020
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STING 효능제로서의 벤조[b]티오펜 화합물
CASH BRANDON D, CUMMING JARED N, JEWELL JAMES P, LARSEN MATTHEW A, ALTMAN MICHAEL D, LIM JONGWON, HENDERSON TIMOTHY J, LU MIN, CHANG WONSUK, TYAGARAJAN SRIRAM, HAIDLE ANDREW M, LIANG RUI, OTTE RYAN D, SIU TONY, TROTTER BENJAMIN WESLEY
Year of Publication 24.05.2019
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Year of Publication 24.05.2019
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STING 효능제로서 시클릭 디-뉴클레오티드 화합물
CUMMING JARED N, JEWELL JAMES P, TRUONG QUANG T, ALTMAN MICHAEL D, LIM JONGWON, HENDERSON TIMOTHY J, WALSH SHAWN P, LU MIN, CHANG WONSUK, LIANG RUI, CHILDERS MATTHEW LLOYD, LIU HONG, OTTE RYAN D, SIU TONY, ANDRESEN BRIAN, HAIDLE ANDREW MARC, NORTHRUP ALAN B, ZHAO KAKE, TROTTER BENJAMIN WESLEY
Year of Publication 26.03.2018
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Year of Publication 26.03.2018
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Discovery of a 5 H -Benzo[4,5]cyclohepta[1,2- b ]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer
Katz, Jason D., Jewell, James P., Guerin, David J., Lim, Jongwon, Dinsmore, Christopher J., Deshmukh, Sujal V., Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D., Dahlberg, William K., Davis, Lenora, Falcone, Danielle, Gabarda, Ana E., Hang, Gaozhen, Hatch, Harold, Holmes, Rachael, Kunii, Kaiko, Lumb, Kevin J., Lutterbach, Bart, Mathvink, Robert, Nazef, Naim, Patel, Sangita B., Qu, Xianlu, Reilly, John F., Rickert, Keith W., Rosenstein, Craig, Soisson, Stephen M., Spencer, Kerrie B., Szewczak, Alexander A., Walker, Deborah, Wang, Wenxian, Young, Jonathan, Zeng, Qinwen
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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