ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models
Vaisitti, Tiziana, Arruga, Francesca, Vitale, Nicoletta, Lee, Thanh-Trang, Ko, Mira, Chadburn, Amy, Braggio, Esteban, Di Napoli, Arianna, Iannello, Andrea, Allan, John N., Miller, Langdon L., Lannutti, Brian J., Furman, Richard R., Jessen, Katti A., Deaglio, Silvia
Published in Blood (17.06.2021)
Published in Blood (17.06.2021)
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Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
Reich, Siegfried H, Sprengeler, Paul A, Chiang, Gary G, Appleman, James R, Chen, Joan, Clarine, Jeff, Eam, Boreth, Ernst, Justin T, Han, Qing, Goel, Vikas K, Han, Edward Z. R, Huang, Vera, Hung, Ivy N. J, Jemison, Adrianna, Jessen, Katti A, Molter, Jolene, Murphy, Douglas, Neal, Melissa, Parker, Gregory S, Shaghafi, Michael, Sperry, Samuel, Staunton, Jocelyn, Stumpf, Craig R, Thompson, Peggy A, Tran, Chinh, Webber, Stephen E, Wegerski, Christopher J, Zheng, Hong, Webster, Kevin R
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma
Jiang, Vivian Changying, Liu, Yang, Jordan, Alexa, McIntosh, Joseph, Li, Yijing, Che, Yuxuan, Jessen, Katti A., Lannutti, Brian J., Wang, Michael
Published in Journal of hematology and oncology (28.08.2021)
Published in Journal of hematology and oncology (28.08.2021)
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Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy
GARCIA-GARCIA, Celina, IBRAHIM, Yasir H, ROMMEL, Christian, TABERNERO, Josep, BASELGA, Jose, SCALTRITI, Maurizio, SERRA, Violeta, CALVO, Maria Teresa, GUZMAN, Marta, GRUESO, Judit, AURA, Claudia, PEREZ, José, JESSEN, Katti, YI LIU
Published in Clinical cancer research (01.05.2012)
Published in Clinical cancer research (01.05.2012)
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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment
Zeng, Zhihong, Shi, Yue Xi, Tsao, Twee, Qiu, YiHua, Kornblau, Steven M., Baggerly, Keith A., Liu, Wenbin, Jessen, Katti, Liu, Yi, Kantarjian, Hagop, Rommel, Christian, Fruman, David A., Andreeff, Michael, Konopleva, Marina
Published in Blood (27.09.2012)
Published in Blood (27.09.2012)
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Selective Inhibition of Phosphoinositide 3-Kinase p110α Preserves Lymphocyte Function
So, Lomon, Yea, Sung Su, Oak, Jean S., Lu, Mengrou, Manmadhan, Arun, Ke, Qiao Han, Janes, Matthew R., Kessler, Linda V., Kucharski, Jeff M., Li, Lian-Sheng, Martin, Michael B., Ren, Pingda, Jessen, Katti A., Liu, Yi, Rommel, Christian, Fruman, David A.
Published in The Journal of biological chemistry (22.02.2013)
Published in The Journal of biological chemistry (22.02.2013)
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Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid Cancers
Wang, Michael L, Barrientos, Jacqueline C, Furman, Richard R, Mei, Matthew, Barr, Paul M, Choi, Michael Y, de Vos, Sven, Kallam, Avyakta, Patel, Krish, Kipps, Thomas J, Rule, Simon, Flanders, Kate, Jessen, Katti A, Ren, Hong, Riebling, Peter C, Graham, Patricia, King, Lydia, Thurston, Archie W, Sun, Michael, Schmidt, Elizabeth M, Lannutti, Brian J, Johnson, David M, Miller, Langdon L, Spurgeon, Stephen E
Published in NEJM evidence (01.01.2022)
Published in NEJM evidence (01.01.2022)
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PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models
Winkler, David G., Faia, Kerrie L., DiNitto, Jonathan P., Ali, Janid A., White, Kerry F., Brophy, Erin E., Pink, Melissa M., Proctor, Jennifer L., Lussier, Jennifer, Martin, Christian M., Hoyt, Jennifer G., Tillotson, Bonnie, Murphy, Erin L., Lim, Alice R., Thomas, Brian D., MacDougall, John R., Ren, Pingda, Liu, Yi, Li, Lian-Sheng, Jessen, Katti A., Fritz, Christian C., Dunbar, Joi L., Porter, James R., Rommel, Christian, Palombella, Vito J., Changelian, Paul S., Kutok, Jeffery L.
Published in Chemistry & biology (21.11.2013)
Published in Chemistry & biology (21.11.2013)
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The translational landscape of mTOR signalling steers cancer initiation and metastasis
Hsieh, Andrew C., Liu, Yi, Edlind, Merritt P., Ingolia, Nicholas T., Janes, Matthew R., Sher, Annie, Shi, Evan Y., Stumpf, Craig R., Christensen, Carly, Bonham, Michael J., Wang, Shunyou, Ren, Pingda, Martin, Michael, Jessen, Katti, Feldman, Morris E., Weissman, Jonathan S., Shokat, Kevan M., Rommel, Christian, Ruggero, Davide
Published in Nature (London) (03.05.2012)
Published in Nature (London) (03.05.2012)
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The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents
Spriano, Filippo, Chung, Elaine Yee Lin, Gaudio, Eugenio, Tarantelli, Chiara, Cascione, Luciano, Napoli, Sara, Jessen, Katti, Carrassa, Laura, Priebe, Valdemar, Sartori, Giulio, Graham, Garrett, Selvanathan, Saravana P, Cavalli, Andrea, Rinaldi, Andrea, Kwee, Ivo, Testoni, Monica, Genini, Davide, Ye, B Hilda, Zucca, Emanuele, Stathis, Anastasios, Lannutti, Brian, Toretsky, Jeffrey A, Bertoni, Francesco
Published in Clinical cancer research (15.08.2019)
Published in Clinical cancer research (15.08.2019)
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Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)
Lock, Richard B., Evans, Kathryn, El-Zein, Narimanne, Lannutti, Brian J., Jessen, Katti A., Earley, Eric J., Erickson, Stephen W., Smith, Malcolm A., Kurmasheva, Raushan, Houghton, Peter J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Targeting ROR1 Using the Antibody Drug Conjugate Vls-101 in Aggressive Mantle Cell Lymphoma
Jiang, Vivian Changying, Liu, Yang, McIntosh, Joseph, Jordan, Alexa A, Leeming, Angela, Chen, Zhihong, Jessen, Katti A., Lannutti, Brian J., Wang, Michael
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma
Selvanathan, Saravana P., Moseley, Eric, Graham, Garrett T., Jessen, Katti, Lannutti, Brian, Üren, Aykut, Toretsky, Jeffrey A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)
Vaisitti, Tiziana, Jessen, Katti, Vo, Thanh-Trang, Ko, Mira, Arruga, Francesca, Vitale, Nicoletta, Braggio, Esteban, Di Napoli, Arianna, Chadburn, Amy, Allan, John N., Furman, Richard R., Miller, Langdon L., Lanutti, Brian J, Deaglio, Silvia
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Abstract LB187: Investigating the roles of ROR1/2 in non-small cell lung carcinoma NSCLC and potential therapeutic applications
Pan, Wen-An, Guo, Xin, Galang, Christina, Ko, Mira, Kucharski, Jeff, Miller, Nicole, Moskowitz, Haim, Watkins, Jeff, Lannutti, Brian, Jessen, Katti, Liu, Hao
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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VLS-101, a ROR1-Targeting Antibody-Drug Conjugate, Demonstrates a Predictable Safety Profile and Clinical Efficacy in Patients with Heavily Pretreated Mantle Cell Lymphoma and Diffuse Large B-Cell Lymphoma
Wang, Michael, Barrientos, Jacqueline C., Furman, Richard R., Mei, Matthew, Barr, Paul M., Choi, Michael Y., de Vos, Sven, Kallam, Avyakta, Patel, Krish, Rule, Simon, Flanders, Kate, Jessen, Katti A., Riebling, Peter C., Graham, Patricia, King, Lydia, Schmidt, Elizabeth M., Lannutti, Brian J., Johnson, David M., Miller, Langdon L., Spurgeon, Stephen E.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia
Janes, M R, Vu, C, Mallya, S, Shieh, M P, Limon, J J, Li, L-S, Jessen, K A, Martin, M B, Ren, P, Lilly, M B, Sender, L S, Liu, Y, Rommel, C, Fruman, D A
Published in Leukemia (01.03.2013)
Published in Leukemia (01.03.2013)
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Abstract 1905: The ROR1 antibody-drug conjugate, MK-2140, enhances the efficacy of established drugs in preclinical models of pediatric acute lymphoblastic leukemia
Lock, Richard B., Evans, Kathryn, Watts, Ben, Bowman, Edward P., Neuhauser, Steven, Stearns, Timothy, Chuang, Jeffrey H., Phillip, Vivek M., Jessen, Katti A., Jocoy, Emily L., Bult, Carol J., Teicher, Beverly A., Smith, Malcolm A.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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