Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Chakraborty, Abhishek A, Laukka, Tuomas, Myllykoski, Matti, Ringel, Alison E, Booker, Matthew A, Tolstorukov, Michael Y, Meng, Yuzhong Jeff, Meier, Samuel R, Jennings, Rebecca B, Creech, Amanda L, Herbert, Zachary T, McBrayer, Samuel K, Olenchock, Benjamin A, Jaffe, Jacob D, Haigis, Marcia C, Beroukhim, Rameen, Signoretti, Sabina, Koivunen, Peppi, Kaelin, Jr, William G
Published in Science (American Association for the Advancement of Science) (15.03.2019)
Published in Science (American Association for the Advancement of Science) (15.03.2019)
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Journal Article
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Oser, Matthew G, Fonseca, Raquel, Chakraborty, Abhishek A, Brough, Rachel, Spektor, Alexander, Jennings, Rebecca B, Flaifel, Abdallah, Novak, Jesse S, Gulati, Aditi, Buss, Elizabeth, Younger, Scott T, McBrayer, Samuel K, Cowley, Glenn S, Bonal, Dennis M, Nguyen, Quang-De, Brulle-Soumare, Laura, Taylor, Paula, Cairo, Stefano, Ryan, Colm J, Pease, Elizabeth J, Maratea, Kim, Travers, Jon, Root, David E, Signoretti, Sabina, Pellman, David, Ashton, Susan, Lord, Christopher J, Barry, Simon T, Kaelin, Jr, William G
Published in Cancer discovery (01.02.2019)
Published in Cancer discovery (01.02.2019)
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Journal Article
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
Oser, Matthew G, Sabet, Amin H, Gao, Wenhua, Chakraborty, Abhishek A, Schinzel, Anna C, Jennings, Rebecca B, Fonseca, Raquel, Bonal, Dennis M, Booker, Matthew A, Flaifel, Abdallah, Novak, Jesse S, Christensen, Camilla L, Zhang, Hua, Herbert, Zachary T, Tolstorukov, Michael Y, Buss, Elizabeth J, Wong, Kwok-Kin, Bronson, Roderick T, Nguyen, Quang-De, Signoretti, Sabina, Kaelin, Jr, William G
Published in Genes & development (01.12.2019)
Published in Genes & development (01.12.2019)
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PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN
Flaifel, Abdallah, Xie, Wanling, Braun, David A, Ficial, Miriam, Bakouny, Ziad, Nassar, Amin H, Jennings, Rebecca B, Escudier, Bernard, George, Daniel J, Motzer, Robert J, Morris, Michael J, Powles, Thomas, Wang, Evelyn, Huang, Ying, Freeman, Gordon J, Choueiri, Toni K, Signoretti, Sabina
Published in Clinical cancer research (15.10.2019)
Published in Clinical cancer research (15.10.2019)
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Shi, Diana D, Savani, Milan R, Levitt, Michael M, Wang, Adam C, Endress, Jennifer E, Bird, Cylaina E, Buehler, Joseph, Stopka, Sylwia A, Regan, Michael S, Lin, Yu-Fen, Puliyappadamba, Vinesh T, Gao, Wenhua, Khanal, Januka, Evans, Laura, Lee, Joyce H, Guo, Lei, Xiao, Yi, Xu, Min, Huang, Bofu, Jennings, Rebecca B, Bonal, Dennis M, Martin-Sandoval, Misty S, Dang, Tammie, Gattie, Lauren C, Cameron, Amy B, Lee, Sungwoo, Asara, John M, Kornblum, Harley I, Mak, Tak W, Looper, Ryan E, Nguyen, Quang-De, Signoretti, Sabina, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Lehrman, Mark A, Zacharias, Lauren G, Mathews, Thomas P, Losman, Julie-Aurore, Richardson, Timothy E, Cahill, Daniel P, DeBerardinis, Ralph J, Ligon, Keith L, Xu, Lin, Ly, Peter, Agar, Nathalie Y R, Abdullah, Kalil G, Harris, Isaac S, Kaelin, Jr, William G, McBrayer, Samuel K
Published in Cancer cell (12.09.2022)
Published in Cancer cell (12.09.2022)
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Journal Article
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
Nicholson, Hilary E, Tariq, Zeshan, Housden, Benjamin E, Jennings, Rebecca B, Stransky, Laura A, Perrimon, Norbert, Signoretti, Sabina, Kaelin, Jr, William G
Published in Science signaling (01.10.2019)
Published in Science signaling (01.10.2019)
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Journal Article
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
McBrayer, Samuel K., Olenchock, Benjamin A., DiNatale, Gabriel J., Shi, Diana D., Khanal, Januka, Jennings, Rebecca B., Novak, Jesse S., Oser, Matthew G., Robbins, Alissa K., Modiste, Rebecca, Bonal, Dennis, Moslehi, Javid, Bronson, Roderick T., Neuberg, Donna, Nguyen, Quang-De, Signoretti, Sabina, Losman, Julie-Aurore, Kaelin, William G.
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2018)
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Journal Article
Enough is not enough : medical students’ knowledge of early warning signs of childhood cancer
Krook, L E, Geel, J A, Fox, T J, Stevenson, B T, Winnan, S J, Nyati, L, Jennings, R B, Katz, B T
Published in South African medical journal (01.07.2017)
Published in South African medical journal (01.07.2017)
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Journal Article
Prognostic significance of CD73 expression in localized renal cell carcinoma (RCC)
Tripathi, Abhishek, Xie, Wanling, Flaifel, Abdallah, Steinharter, John A., Stern Gatof, Emily, Jennings, Rebecca B, Bouchard, Gabrielle, Fleischer, Justin, Chanza, Nieves M., Gray, Connor, Mantia, Charlene, Wei, Xiao X., Giannakis, Marios, McGregor, Bradley Alexander, Choueiri, Toni K., McDermott, David F., Signoretti, Sabina, Harshman, Lauren Christine
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
Association of human endogenous retrovirus (hERV) expression with clinical efficacy of PD-1 blockade in metastatic clear cell renal cell carcinoma (mccRCC)
Pignon, Jean-Christophe, Jegede, Opeyemi, Shukla, Sachet A, Braun, David A., Horak, Christine, Wind-Rotolo, Megan, Ishii, Yuko, Catalano, Paul J., Freeman, Gordon J., Jennings, Rebecca B, De Cubas, Aguirre, Rathmell, Kimryn, Choueiri, Toni K., Atkins, Michael B., McDermott, David F., Signoretti, Sabina
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma
Shi, Diana D, Savani, Milan R, Levitt, Michael M, Wang, Adam C, Endress, Jennifer E, Bird, Cylaina E, Buehler, Joseph, Stopka, Sylwia A, Regan, Michael S, Yu-Fen, Lin, Gao, Wenhua, Khanal, Januka, Xu, Min, Huang, Bofu, Jennings, Rebecca B, Bonal, Dennis M, Martin-Sandoval, Misty S, Dang, Tammie, Gattie, Lauren C, Lee, Sungwoo, Asara, John M, Kornblum, Harley I, Mak, Tak W, Looper, Ryan E, Quang-De Nguyen, Signoretti, Sabina, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Lehrman, Mark A, Zacharias, Lauren G, Mathews, Thomas P, Richardson, Timothy E, Cahill, Daniel P, Deberardinis, Ralph J, Ligon, Keith L, Ly, Peter, Agar, Nathalie Y R, Abdullah, Kalil G, Harris, Isaac S, Kaelin, William G, Mcbrayer, Samuel K
Published in bioRxiv (01.12.2021)
Published in bioRxiv (01.12.2021)
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