Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data
O'Donovan, Shauna D, Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J, van Riel, Natal A. W, Driessens, Kurt, Peeters, Ralf L. M, de Kok, Theo M. C. M
Published in PloS one (30.11.2023)
Published in PloS one (30.11.2023)
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Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification
Jennen, Danyel G. J., Magkoufopoulou, Christina, Ketelslegers, Hans B., van Herwijnen, Marcel H. M., Kleinjans, Jos C. S., van Delft, Joost H. M.
Published in Toxicological sciences (01.05.2010)
Published in Toxicological sciences (01.05.2010)
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A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids
Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C S, Jennen, Danyel G J, de Kok, Theo M
Published in International journal of molecular sciences (17.02.2022)
Published in International journal of molecular sciences (17.02.2022)
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DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks
Kuijpers, T J M, Wolters, J E J, Kleinjans, J C S, Jennen, D G J
Published in BMC bioinformatics (13.08.2019)
Published in BMC bioinformatics (13.08.2019)
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Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response
Jennen, Danyel G J, van Herwijnen, Marcel, Jetten, Marlon, Vandebriel, Rob J, Keizers, Peter, Geertsma, Robert E, de Jong, Wim H, Kleinjans, Jos C S
Published in International journal of molecular sciences (27.10.2022)
Published in International journal of molecular sciences (27.10.2022)
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Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes
O'Donovan, Shauna D, Driessens, Kurt, Lopatta, Daniel, Wimmenauer, Florian, Lukas, Alexander, Neeven, Jelmer, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G J, van Riel, Natal A W, Cavill, Rachel, Peeters, Ralf L M, de Kok, Theo M C M
Published in PloS one (11.08.2020)
Published in PloS one (11.08.2020)
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Xenobiotic metabolism in differentiated human bronchial epithelial cells
Boei, Jan J. W. A., Vermeulen, Sylvia, Klein, Binie, Hiemstra, Pieter S., Verhoosel, Renate M., Jennen, Danyel G. J., Lahoz, Agustin, Gmuender, Hans, Vrieling, Harry
Published in Archives of toxicology (01.05.2017)
Published in Archives of toxicology (01.05.2017)
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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity
Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M., Rodrigues, Daniela, Jennen, Danyel G. J., de Kok, Theo M., Coyle, Luke, Chung, Seung‐Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A., Kelly, Colette, Duckworth, Carrie A., Pritchard, D. Mark, Pin, Carmen
Published in CPT: pharmacometrics and systems pharmacology (01.10.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.10.2023)
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The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer
Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M
Published in Nanomaterials (Basel, Switzerland) (01.04.2022)
Published in Nanomaterials (Basel, Switzerland) (01.04.2022)
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Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes
MATHIJS, Karen, KIENHUIS, Anne S, BRAUERS, Karen J. J, JENNEN, Danyel G. J, LAHOZ, Agustin, KLEINJANS, Jos C. S, VAN DELFT, Joost H. M
Published in Drug metabolism and disposition (01.06.2009)
Published in Drug metabolism and disposition (01.06.2009)
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Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis
van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H. J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theo M. C. M., Kleinjans, Jos C. S.
Published in Archives of toxicology (01.11.2015)
Published in Archives of toxicology (01.11.2015)
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The exposome concept in a human nutrigenomics study: evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures
van Breda, Simone G J, Wilms, Lonneke C, Gaj, Stan, Jennen, Danyel G J, Briedé, Jacob J, Kleinjans, Jos C S, de Kok, Theo M C M
Published in Mutagenesis (01.11.2015)
Published in Mutagenesis (01.11.2015)
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Reply to Kaminski, N.E.; Cohen, S.M. Comment on "Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12 , 1256"
Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M
Published in Nanomaterials (Basel, Switzerland) (05.05.2023)
Published in Nanomaterials (Basel, Switzerland) (05.05.2023)
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genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population
Liu, G, Jennen, D.G.J, Tholen, E, Juengst, H, Kleinwächter, T, Hölker, M, Tesfaye, D, Ün, G, Schreinemachers, H.-J, Murani, E, Ponsuksili, S, Kim, J.-J, Schellander, K, Wimmers, K
Published in Animal genetics (01.06.2007)
Published in Animal genetics (01.06.2007)
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Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans
Jennen, Danyel G. J, van Leeuwen, Danitsja M, Hendrickx, Diana M, Gottschalk, Ralph W. H, van Delft, Joost H. M, Kleinjans, Jos C. S
Published in Chemical research in toxicology (19.10.2015)
Published in Chemical research in toxicology (19.10.2015)
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New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids
Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.
Published in Archives of toxicology (01.08.2021)
Published in Archives of toxicology (01.08.2021)
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Journal Article
Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes
Jennen, Danyel G.J., Gaj, Stan, Giesbertz, Pieter J., van Delft, Joost H.M., Evelo, Chris T., Kleinjans, Jos C.S.
Published in Drug discovery today (01.10.2010)
Published in Drug discovery today (01.10.2010)
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Transcriptomic network analysis of micronuclei-related genes: a case study
van Leeuwen, D M, Pedersen, M, Knudsen, L E, Bonassi, S, Fenech, M, Kleinjans, J C S, Jennen, D G J
Published in Mutagenesis (01.01.2011)
Published in Mutagenesis (01.01.2011)
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