Transcriptomic and metabolomic data integration
Cavill, Rachel, Jennen, Danyel, Kleinjans, Jos, Briedé, Jacob Jan
Published in Briefings in bioinformatics (01.09.2016)
Published in Briefings in bioinformatics (01.09.2016)
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Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma
Rieswijk, Linda, Claessen, Sandra M.H, Bekers, Otto, Herwijnen, Marcel van, Theunissen, Daniël H.J, Jennen, Danyel G.J, de Kok, Theo M.C.M, Kleinjans, Jos C.S, van Breda, Simone G.J
Published in Toxicology (Amsterdam) (28.03.2016)
Published in Toxicology (Amsterdam) (28.03.2016)
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Xenobiotic metabolism in differentiated human bronchial epithelial cells
Boei, Jan J. W. A., Vermeulen, Sylvia, Klein, Binie, Hiemstra, Pieter S., Verhoosel, Renate M., Jennen, Danyel G. J., Lahoz, Agustin, Gmuender, Hans, Vrieling, Harry
Published in Archives of toxicology (01.05.2017)
Published in Archives of toxicology (01.05.2017)
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Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data
O'Donovan, Shauna D, Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J, van Riel, Natal A. W, Driessens, Kurt, Peeters, Ralf L. M, de Kok, Theo M. C. M
Published in PloS one (30.11.2023)
Published in PloS one (30.11.2023)
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New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids
Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.
Published in Archives of toxicology (01.08.2021)
Published in Archives of toxicology (01.08.2021)
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Journal Article
Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes
O'Donovan, Shauna D, Driessens, Kurt, Lopatta, Daniel, Wimmenauer, Florian, Lukas, Alexander, Neeven, Jelmer, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G J, van Riel, Natal A W, Cavill, Rachel, Peeters, Ralf L M, de Kok, Theo M C M
Published in PloS one (11.08.2020)
Published in PloS one (11.08.2020)
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Integrating SNPs-based genetic risk factor with blood epigenomic response of differentially arsenic-exposed rural subjects reveals disease-associated signaling pathways
Rehman, Muhammad Yasir Abdur, Briedé, Jacco Jan, van Herwijnen, Marcel, Krauskopf, Julian, Jennen, Danyel G.J., Malik, Riffat Naseem, Kleinjans, Jos C.S.
Published in Environmental pollution (1987) (01.01.2022)
Published in Environmental pollution (1987) (01.01.2022)
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Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain
Jiang, Jian, Briedé, Jacob J., Jennen, Danyel G.J., Van Summeren, Anke, Saritas-Brauers, Karen, Schaart, Gert, Kleinjans, Jos C.S., de Kok, Theo M.C.M.
Published in Toxicology letters (16.04.2015)
Published in Toxicology letters (16.04.2015)
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Journal Article
Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification
Jennen, Danyel G. J., Magkoufopoulou, Christina, Ketelslegers, Hans B., van Herwijnen, Marcel H. M., Kleinjans, Jos C. S., van Delft, Joost H. M.
Published in Toxicological sciences (01.05.2010)
Published in Toxicological sciences (01.05.2010)
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Journal Article
Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches
Rodrigues, Daniela, Souza, Terezinha, Jennen, Danyel G.J., Lemmens, Lieve, Kleinjans, Jos C.S., de Kok, Theo M.
Published in Cancer treatment reviews (01.07.2019)
Published in Cancer treatment reviews (01.07.2019)
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Journal Article
A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids
Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C S, Jennen, Danyel G J, de Kok, Theo M
Published in International journal of molecular sciences (17.02.2022)
Published in International journal of molecular sciences (17.02.2022)
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Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics
Smit, Evelyn, Souza, Terezinha, Jennen, Danyel G.J., Kleinjans, Jos C.S., van den Beucken, Twan
Published in Toxicology (Amsterdam) (01.09.2017)
Published in Toxicology (Amsterdam) (01.09.2017)
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Journal Article
Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids
Rodrigues, Daniela, van Kampen, Roel, van Bodegraven, Ad A., Kleinjans, Jos C.S., Jennen, Danyel G.J., de Kok, Theo M.
Published in Toxicology letters (01.12.2022)
Published in Toxicology letters (01.12.2022)
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Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction
van Breda, Simone G.J., Claessen, Sandra M.H., van Herwijnen, Marcel, Theunissen, Daniël H.J., Jennen, Danyel G.J., de Kok, Theo M.C.M., Kleinjans, Jos C.S.
Published in Toxicology (Amsterdam) (15.01.2018)
Published in Toxicology (Amsterdam) (15.01.2018)
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Journal Article
Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis
van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H. J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theo M. C. M., Kleinjans, Jos C. S.
Published in Archives of toxicology (01.11.2015)
Published in Archives of toxicology (01.11.2015)
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Journal Article
Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response
Jennen, Danyel G J, van Herwijnen, Marcel, Jetten, Marlon, Vandebriel, Rob J, Keizers, Peter, Geertsma, Robert E, de Jong, Wim H, Kleinjans, Jos C S
Published in International journal of molecular sciences (27.10.2022)
Published in International journal of molecular sciences (27.10.2022)
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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity
Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M, Rodrigues, Daniela, Jennen, Danyel G J, de Kok, Theo M, Coyle, Luke, Chung, Seung-Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A, Kelly, Colette, Duckworth, Carrie A, Pritchard, D Mark, Pin, Carmen
Published in CPT: pharmacometrics and systems pharmacology (01.10.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.10.2023)
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The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer
Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M
Published in Nanomaterials (Basel, Switzerland) (01.04.2022)
Published in Nanomaterials (Basel, Switzerland) (01.04.2022)
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Journal Article
Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood
Pennings, Jeroen L. A., Jennen, Danyel G. J., Nygaard, Unni C., Namork, Ellen, Haug, Line S., van Loveren, Henk, Granum, Berit
Published in Journal of immunotoxicology (03.03.2016)
Published in Journal of immunotoxicology (03.03.2016)
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