Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma
Wang, Lin, Jenkins, Tracy J, Dai, Mingshi, Yin, Wei, Pulido, Jacqueline C, LaMantia-Martin, Elise, Hodge, Martin R, Ocain, Timothy, Kolbeck, Roland
Published in Thorax (01.06.2013)
Published in Thorax (01.06.2013)
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Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
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Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model
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Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens
Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Marcotte, Douglas, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Otipoby, Kevin L., Poreci, Urjana, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min
Published in Bioorganic & medicinal chemistry (01.07.2019)
Published in Bioorganic & medicinal chemistry (01.07.2019)
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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors
Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Gua, Chuck, Liu, Ying, Liu, YuTing, Lulla, Mukush, Marcotte, Douglas, Marx, Isaac, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min
Published in Bioorganic & medicinal chemistry (15.08.2021)
Published in Bioorganic & medicinal chemistry (15.08.2021)
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Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
Marcotte, Douglas J., Liu, Yu‐Ting, Arduini, Robert M., Hession, Catherine A., Miatkowski, Konrad, Wildes, Craig P., Cullen, Patrick F., Hong, Victor, Hopkins, Brian T., Mertsching, Elisabeth, Jenkins, Tracy J., Romanowski, Michael J., Baker, Darren P., Silvian, Laura F.
Published in Protein science (01.03.2010)
Published in Protein science (01.03.2010)
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Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4
Blackburn, Christopher, Guan, Bing, Brown, James, Cullis, Courtney, Condon, Stephen M., Jenkins, Tracy J., Peluso, Stephane, Ye, Yingchun, Gimeno, Ruth E., Punreddy, Sandhya, Sun, Ying, Wu, Hui, Hubbard, Brian, Kaushik, Virendar, Tummino, Peter, Sanchetti, Praveen, Yu Sun, Dong, Daniels, Tom, Tozzo, Effie, Balani, Suresh K., Raman, Prakash
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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PYRIMIDINYL TYROSINE KINASE INHIBITORS
HOPKINS BRIAN T, CONLON PATRICK, SHI XIANGLIN, THOMPSON ANDREW, CAI XIONGWEI, CHAN TIMOTHY R, MILLER ROSS A, HUMORA MICHAEL, JENKINS TRACY J
Year of Publication 22.11.2022
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Year of Publication 22.11.2022
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PYRIMIDINYL TYROSINE KINASE INHIBITORS
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Year of Publication 16.06.2021
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PYRIMIDINYL TYROSINE KINASE INHIBITORS
HOPKINS BRIAN T, CONLON PATRICK, SHI XIANGLIN, THOMPSON ANDREW, CAI XIONGWEI, CHAN TIMOTHY R, MILLER ROSS A, HUMORA MICHAEL, JENKINS TRACY J
Year of Publication 27.04.2020
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Year of Publication 27.04.2020
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Geminal Acylation with Methyl-Substituted Analogues of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene
Crane, Sheldon N, Jenkins, Tracy J, Burnell, D. Jean
Published in Journal of organic chemistry (12.12.1997)
Published in Journal of organic chemistry (12.12.1997)
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BRUTON'S TYROSINE KINASE INHIBITORS
TAVERAS, Art, MARCOTTE, Doug, ERLANSON, Daniel A, KUMARAVEL, Gnanasambandam, HOPKINS, Brian T, SILVIAN, Laura, JENKINS, Tracy J, LUGOVSKOY, Alexey A, CUERVO, Julio H, BUI, Minna, SCOTT, Daniel, CONLON, Patrick R, WANG, Deping, FAN, Junfa, GUAN, Bing, POWELL, Noel, ZHONG, Min
Year of Publication 25.07.2024
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Year of Publication 25.07.2024
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PYRIMIDINYL TYROSINE KINASE INHIBITORS
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Year of Publication 08.06.2023
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Year of Publication 08.06.2023
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Pyrimidinyl tyrosine kinase inhibitors
CAI, Xiongwei, MILLER, Ross A, SHI, Xianglin, THOMPSON, Andrew, HUMORA, Michael, CHAN, Timothy R, HOPKINS, Brian T, JENKINS, Tracy J, CONLON, Patrick
Year of Publication 05.01.2023
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Year of Publication 05.01.2023
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BRUTON'S TYROSINE KINASE INHIBITORS
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Year of Publication 07.03.2023
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Year of Publication 07.03.2023
Patent
BRUTON'S TYROSINE KINASE INHIBITORS
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Year of Publication 16.02.2023
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Year of Publication 16.02.2023
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Pyrimidinyl tyrosine kinase inhibitors
Brian T. Hopkins, Ross A. Miller, Andrew Thompson, Michael Humora, Xianglin Shi, Tracy J. Jenkins, Xiongwei Cai, Patrick Conlon, Timothy R. Chan
Year of Publication 20.05.2021
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Year of Publication 20.05.2021
Patent