Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model
Vandeveer, George H., Arduini, Robert M., Baker, Darren P., Barry, Kevin, Bohnert, Tonika, Bowden-Verhoek, Jon K., Conlon, Patrick, Cullen, Patrick F., Guan, Bing, Jenkins, Tracy J., Liao, Shu-Yu, Lin, Lin, Liu, Yu-Ting, Marcotte, Douglas, Mertsching, Elisabeth, Metrick, Claire M., Negrou, Ella, Powell, Noel, Scott, Daniel, Silvian, Laura F., Hopkins, Brian T.
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens
Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Marcotte, Douglas, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Otipoby, Kevin L., Poreci, Urjana, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min
Published in Bioorganic & medicinal chemistry (01.07.2019)
Published in Bioorganic & medicinal chemistry (01.07.2019)
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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors
Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Gua, Chuck, Liu, Ying, Liu, YuTing, Lulla, Mukush, Marcotte, Douglas, Marx, Isaac, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min
Published in Bioorganic & medicinal chemistry (15.08.2021)
Published in Bioorganic & medicinal chemistry (15.08.2021)
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Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
Marcotte, Douglas J., Liu, Yu‐Ting, Arduini, Robert M., Hession, Catherine A., Miatkowski, Konrad, Wildes, Craig P., Cullen, Patrick F., Hong, Victor, Hopkins, Brian T., Mertsching, Elisabeth, Jenkins, Tracy J., Romanowski, Michael J., Baker, Darren P., Silvian, Laura F.
Published in Protein science (01.03.2010)
Published in Protein science (01.03.2010)
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Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma
Wang, Lin, Jenkins, Tracy J, Dai, Mingshi, Yin, Wei, Pulido, Jacqueline C, LaMantia-Martin, Elise, Hodge, Martin R, Ocain, Timothy, Kolbeck, Roland
Published in Thorax (01.06.2013)
Published in Thorax (01.06.2013)
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Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4
Blackburn, Christopher, Guan, Bing, Brown, James, Cullis, Courtney, Condon, Stephen M., Jenkins, Tracy J., Peluso, Stephane, Ye, Yingchun, Gimeno, Ruth E., Punreddy, Sandhya, Sun, Ying, Wu, Hui, Hubbard, Brian, Kaushik, Virendar, Tummino, Peter, Sanchetti, Praveen, Yu Sun, Dong, Daniels, Tom, Tozzo, Effie, Balani, Suresh K., Raman, Prakash
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
Jenkins, Tracy J, Guan, Bing, Dai, Mingshi, Li, Gang, Lightburn, Thomas E, Huang, Shan, Freeze, B. Scott, Burdi, Douglas F, Jacutin-Porte, Swanee, Bennett, Robert, Chen, Weirong, Minor, Charles, Ghosh, Shomir, Blackburn, Christopher, Gigstad, Kenneth M, Jones, Matthew, Kolbeck, Roland, Yin, Wei, Smith, Sean, Cardillo, Daniel, Ocain, Timothy D, Harriman, Geraldine C
Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Geminal Acylation with Methyl-Substituted Analogues of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene
Crane, Sheldon N, Jenkins, Tracy J, Burnell, D. Jean
Published in Journal of organic chemistry (12.12.1997)
Published in Journal of organic chemistry (12.12.1997)
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CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling
Henry, Kate L, Kellner, Debra, Bajrami, Bekim, Anderson, John E, Beyna, Mercedes, Bhisetti, Govinda, Cameron, Tom, Capacci, Andrew G, Bertolotti-Ciarlet, Andrea, Feng, Jun, Gao, Benbo, Hopkins, Brian, Jenkins, Tracy, Li, Kejie, May-Dracka, Tricia, Murugan, Paramasivam, Wei, Ru, Zeng, Weike, Allaire, Norm, Buckler, Alan, Loh, Christine, Juhasz, Peter, Lucas, Brian, Ennis, Katelin A, Vollman, Elisabeth, Cahir-McFarland, Ellen, Hett, Erik C, Ols, Michelle L
Published in Science signaling (31.07.2018)
Published in Science signaling (31.07.2018)
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Journal Article
PYRIMIDINYL TYROSINE KINASE INHIBITORS
HOPKINS BRIAN T, CONLON PATRICK, SHI XIANGLIN, THOMPSON ANDREW, CAI XIONGWEI, CHAN TIMOTHY R, MILLER ROSS A, HUMORA MICHAEL, JENKINS TRACY J
Year of Publication 22.11.2022
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Year of Publication 22.11.2022
Patent
The Archaeology of Early African American Communities in Talbot County, Eastern Shore, Maryland, U.S.A., and Their Relationship to Slavery
Leone, Mark P., Pruitt, Elizabeth, Skolnik, Benjamin A., Woehlke, Stefan, Jenkins, Tracy
Published in Historical archaeology (01.12.2018)
Published in Historical archaeology (01.12.2018)
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Journal Article
How Can There Be No History?
Leone, Mark P., Jenkins, Tracy, Woehlke, Stefan, Deeley, Kathryn, Hutchinson, Brittany, Pruitt, Elizabeth, Skolnik, Benjamin A.
Published in Historical archaeology (01.12.2019)
Published in Historical archaeology (01.12.2019)
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Journal Article
PYRIMIDINYL TYROSINE KINASE INHIBITORS
HOPKINS BRIAN T, CONLON PATRICK, SHI XIANGLIN, THOMPSON ANDREW, CAI XIONGWEI, CHAN TIMOTHY R, MILLER ROSS A, HUMORA MICHAEL, JENKINS TRACY J
Year of Publication 16.06.2021
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Year of Publication 16.06.2021
Patent
PYRIMIDINYL TYROSINE KINASE INHIBITORS
HOPKINS BRIAN T, CONLON PATRICK, SHI XIANGLIN, THOMPSON ANDREW, CAI XIONGWEI, CHAN TIMOTHY R, MILLER ROSS A, HUMORA MICHAEL, JENKINS TRACY J
Year of Publication 27.04.2020
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Year of Publication 27.04.2020
Patent