Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
Franklin, Robert D., Armiger, Travis, Otte, Douglas A. L., Larson, Reed T., Spencer, Glenn, Patel, Pratiq A., Paulines, Mellie June, Hall, Jackson R., Xiao, Kai-Jiong, Fier, Patrick S., Rodrigues, Vailankanni L., Guetschow, Erik D., Kuhl, Nadine, Jellett, Lisa, Corry, James, Chung, Cheol K., Thaisrivongs, David A.
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
Get full text
Journal Article
A Holistic Strategy for Cyanide Control and Safety for Pharmaceutical Manufacturing
Zompa, Michael A, Di Maso, Michael J, Guzman, Francisco, Zhao, Ralph, Jellett, Lisa, Arvary, Rebecca, Song, Siqing, Chang, Darryl, Ren, Hong, Lohani, Sachin
Published in Organic process research & development (20.08.2021)
Published in Organic process research & development (20.08.2021)
Get full text
Journal Article
Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)
Deprez, Nicholas R., Rose, Harrison B., Peters, Byron K., Diaz-Santana, Anthony, Liu, Zhuqing, Kuhl, Nadine, Chung, Cheol K., Liu, Zhu, Newman, Justin A., Corry, James, Guetschow, Erik D., Hoyt, Erik, Jellett, Lisa, Kapil, Sunayana, Poirier, Marc, Shevlin, Michael, Sirota, Eric, Solovyov, Andrew, Sun, Alexandra C., Thaisrivongs, David A.
Published in Organic process research & development (17.11.2023)
Published in Organic process research & development (17.11.2023)
Get full text
Journal Article
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Otte, Douglas A. L., Larson, Reed T., Alwedi, Embarek, Armiger, Travis, Chen, Yonggang, Chung, Cheol K., Corry, James, Desmond, Richard, Fier, Patrick S., Franklin, Robert D., Guetschow, Erik D., Hall, Jackson R., Halsey, Holst M., Hartmanshenn, Clara, Jellett, Lisa, Kuhl, Nadine, Lévesque, François, McMullen, Jonathan P., Patel, Pratiq A., Paulines, Mellie June, Ren, Hong, Rodrigues, Vailankanni L., Ruccolo, Serge, Tan, Lushi, Thaisrivongs, David A., Xiao, Kai-Jiong
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
Get full text
Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch–Batch Process
Otte, Douglas A. L, Basu, Kallol, Jellett, Lisa, Whittington, Michael, Spencer, Glenn, Burris, Matthew, Corcoran, Emily B, Stone, Kevin, Nappi, Jarod, Arvary, Rebecca A, Donoghue, David, Ren, Hong, Maloney, Kevin M, Naber, John R
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
Get full text
Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
Get full text
Journal Article