Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review
Ruberg, Frederick L, Grogan, Martha, Hanna, Mazen, Kelly, Jeffery W, Maurer, Mathew S
Published in Journal of the American College of Cardiology (11.06.2019)
Published in Journal of the American College of Cardiology (11.06.2019)
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Journal Article
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.
Published in Nature communications (14.01.2019)
Published in Nature communications (14.01.2019)
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Journal Article
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
Lee, Jiyong, Culyba, Elizabeth K, Powers, Evan T, Kelly, Jeffery W
Published in Nature chemical biology (31.07.2011)
Published in Nature chemical biology (31.07.2011)
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Journal Article
Adapting Proteostasis for Disease Intervention
Balch, William E, Morimoto, Richard I, Dillin, Andrew, Kelly, Jeffery W
Published in Science (American Association for the Advancement of Science) (15.02.2008)
Published in Science (American Association for the Advancement of Science) (15.02.2008)
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Journal Article
Biological and chemical approaches to diseases of proteostasis deficiency
Powers, Evan T, Morimoto, Richard I, Dillin, Andrew, Kelly, Jeffery W, Balch, William E
Published in Annual review of biochemistry (01.01.2009)
Published in Annual review of biochemistry (01.01.2009)
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Journal Article
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
Johnson, Steven M., Connelly, Stephen, Fearns, Colleen, Powers, Evan T., Kelly, Jeffery W.
Published in Journal of molecular biology (10.08.2012)
Published in Journal of molecular biology (10.08.2012)
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Journal Article
The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis
Hebert, Daniel N, Lamriben, Lydia, Powers, Evan T, Kelly, Jeffery W
Published in Nature chemical biology (01.11.2014)
Published in Nature chemical biology (01.11.2014)
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Journal Article
Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
Shoulders, Matthew D., Ryno, Lisa M., Genereux, Joseph C., Moresco, James J., Tu, Patricia G., Wu, Chunlei, Yates, John R., Su, Andrew I., Kelly, Jeffery W., Wiseman, R. Luke
Published in Cell reports (Cambridge) (25.04.2013)
Published in Cell reports (Cambridge) (25.04.2013)
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Journal Article
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
Mortenson, David E, Brighty, Gabriel J, Plate, Lars, Bare, Grant, Chen, Wentao, Li, Suhua, Wang, Hua, Cravatt, Benjamin F, Forli, Stefano, Powers, Evan T, Sharpless, K. Barry, Wilson, Ian A, Kelly, Jeffery W
Published in Journal of the American Chemical Society (10.01.2018)
Published in Journal of the American Chemical Society (10.01.2018)
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Journal Article
fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function
Araya, Carlos L, Fowler, Douglas M, Chen, Wentao, Muniez, Ike, Kelly, Jeffery W, Fields, Stanley
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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Journal Article
Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis
Alvarez‐Garcia, Oscar, Matsuzaki, Tokio, Olmer, Merissa, Plate, Lars, Kelly, Jeffery W., Lotz, Martin K.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2017)
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Journal Article
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
Bulawa, Christine E, Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A, Packman, Jeff, Powers, Evan T, Wiseman, R. Luke, Foss, Theodore R, Wilson, Ian A, Kelly, Jeffery W, Labaudinière, Richard
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
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