Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
Audrain, Mickael, Haure‐Mirande, Jean‐Vianney, Mleczko, Justyna, Wang, Minghui, Griffin, Jennifer K., St George‐Hyslop, Peter H., Fraser, Paul, Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Published in Alzheimer's & dementia (01.02.2021)
Published in Alzheimer's & dementia (01.02.2021)
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Journal Article
Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
Readhead, Ben, Haure-Mirande, Jean-Vianney, Funk, Cory C., Richards, Matthew A., Shannon, Paul, Haroutunian, Vahram, Sano, Mary, Liang, Winnie S., Beckmann, Noam D., Price, Nathan D., Reiman, Eric M., Schadt, Eric E., Ehrlich, Michelle E., Gandy, Sam, Dudley, Joel T.
Published in Neuron (Cambridge, Mass.) (11.07.2018)
Published in Neuron (Cambridge, Mass.) (11.07.2018)
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Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Published in Molecular psychiatry (01.03.2019)
Published in Molecular psychiatry (01.03.2019)
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Journal Article
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease
Castranio, Emilie L., Hasel, Philip, Haure‐Mirande, Jean‐Vianney, Ramirez Jimenez, Angie V., Hamilton, B. Wade, Kim, Rachel D., Glabe, Charles G., Wang, Minghui, Zhang, Bin, Gandy, Sam, Liddelow, Shane A., Ehrlich, Michelle E.
Published in Alzheimer's & dementia (01.06.2023)
Published in Alzheimer's & dementia (01.06.2023)
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Journal Article
Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
Beckmann, Noam D., Lin, Wei-Jye, Wang, Minghui, Cohain, Ariella T., Charney, Alexander W., Wang, Pei, Ma, Weiping, Wang, Ying-Chih, Jiang, Cheng, Audrain, Mickael, Comella, Phillip H., Fakira, Amanda K., Hariharan, Siddharth P., Belbin, Gillian M., Girdhar, Kiran, Levey, Allan I., Seyfried, Nicholas T., Dammer, Eric B., Duong, Duc, Lah, James J., Haure-Mirande, Jean-Vianney, Shackleton, Ben, Fanutza, Tomas, Blitzer, Robert, Kenny, Eimear, Zhu, Jun, Haroutunian, Vahram, Katsel, Pavel, Gandy, Sam, Tu, Zhidong, Ehrlich, Michelle E., Zhang, Bin, Salton, Stephen R., Schadt, Eric E.
Published in Nature communications (07.08.2020)
Published in Nature communications (07.08.2020)
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Journal Article
Clarifying the Potential Role of Microbes in Alzheimer’s Disease
Readhead, Ben, Haure-Mirande, Jean-Vianney, Ehrlich, Michelle E., Gandy, Sam, Dudley, Joel T.
Published in Neuron (Cambridge, Mass.) (18.12.2019)
Published in Neuron (Cambridge, Mass.) (18.12.2019)
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Journal Article
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology
Haure-Mirande, Jean-Vianney, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Klein, William L., Glabe, Charles, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Wang, Minghui, Zhang, Bin, Schadt, Eric E., Gandy, Sam, Ehrlich, Michelle E.
Published in Acta neuropathologica (01.11.2017)
Published in Acta neuropathologica (01.11.2017)
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Journal Article
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease
Readhead, Ben, Haure-Mirande, Jean-Vianney, Mastroeni, Diego, Audrain, Mickael, Fanutza, Tomas, Kim, Soong H., Blitzer, Robert D., Gandy, Sam, Dudley, Joel T., Ehrlich, Michelle E.
Published in Acta neuropathologica (01.09.2020)
Published in Acta neuropathologica (01.09.2020)
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Journal Article
Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
Audrain, Mickael, Haure-Mirande, Jean-Vianney, Wang, Minghui, Kim, Soong Ho, Fanutza, Tomas, Chakrabarty, Paramita, Fraser, Paul, St George-Hyslop, Peter H., Golde, Todd E., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Ehrlich, Michelle E., Gandy, Sam
Published in Molecular psychiatry (01.09.2019)
Published in Molecular psychiatry (01.09.2019)
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Journal Article
Transcriptomic Changes Highly Similar to Alzheimer's Disease Are Observed in a Subpopulation of Individuals During Normal Brain Aging
Peng, Shouneng, Zeng, Lu, Haure-Mirande, Jean-Vianney, Wang, Minghui, Huffman, Derek M, Haroutunian, Vahram, Ehrlich, Michelle E, Zhang, Bin, Tu, Zhidong
Published in Frontiers in aging neuroscience (01.12.2021)
Published in Frontiers in aging neuroscience (01.12.2021)
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Journal Article
Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models
Wan, Ying-Wooi, Al-Ouran, Rami, Mangleburg, Carl G., Perumal, Thanneer M., Lee, Tom V., Allison, Katherine, Swarup, Vivek, Funk, Cory C., Gaiteri, Chris, Allen, Mariet, Wang, Minghui, Neuner, Sarah M., Kaczorowski, Catherine C., Philip, Vivek M., Howell, Gareth R., Martini-Stoica, Heidi, Zheng, Hui, Mei, Hongkang, Zhong, Xiaoyan, Kim, Jungwoo Wren, Dawson, Valina L., Dawson, Ted M., Pao, Ping-Chieh, Tsai, Li-Huei, Haure-Mirande, Jean-Vianney, Ehrlich, Michelle E., Chakrabarty, Paramita, Levites, Yona, Wang, Xue, Dammer, Eric B., Srivastava, Gyan, Mukherjee, Sumit, Sieberts, Solveig K., Omberg, Larsson, Dang, Kristen D., Eddy, James A., Snyder, Phil, Chae, Yooree, Amberkar, Sandeep, Wei, Wenbin, Hide, Winston, Preuss, Christoph, Ergun, Ayla, Ebert, Phillip J., Airey, David C., Mostafavi, Sara, Yu, Lei, Klein, Hans-Ulrich, Carter, Gregory W., Collier, David A., Golde, Todd E., Levey, Allan I., Bennett, David A., Estrada, Karol, Townsend, T. Matthew, Zhang, Bin, Schadt, Eric, De Jager, Philip L., Price, Nathan D., Ertekin-Taner, Nilüfer, Liu, Zhandong, Shulman, Joshua M., Mangravite, Lara M., Logsdon, Benjamin A.
Published in Cell reports (Cambridge) (14.07.2020)
Published in Cell reports (Cambridge) (14.07.2020)
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Journal Article
BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT mouse model of tauopathy
Perez-Garcia, Georgina, Bicak, Mesude, Haure-Mirande, Jean-Vianney, Perez, Gissel M., Otero-Pagan, Alena, Gama Sosa, Miguel A., De Gasperi, Rita, Sano, Mary, Barlow, Carrolee, Gage, Fred H., Readhead, Benjamin, Ehrlich, Michelle E., Gandy, Sam, Elder, Gregory A.
Published in Neuroscience letters (16.02.2023)
Published in Neuroscience letters (16.02.2023)
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Journal Article
TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
Creus-Muncunill, Jordi, Haure-Mirande, Jean Vianney, Mattei, Daniele, Bons, Joanna, Ramirez, Angie V, Hamilton, B Wade, Corwin, Chuhyon, Chowdhury, Sarah, Schilling, Birgit, Ellerby, Lisa M, Ehrlich, Michelle E
Published in Journal of neuroinflammation (08.03.2024)
Published in Journal of neuroinflammation (08.03.2024)
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Journal Article
Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma
Dunkin, David, Iuga, Alina C, Mimouna, Sanda, Harris, Carolyn L, Haure-Mirande, Jean-Vianney, Bozec, Dominique, Yeretssian, Garabet, Dahan, Stephanie
Published in Oncotarget (11.09.2018)
Published in Oncotarget (11.09.2018)
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Journal Article
Correction: Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Published in Molecular psychiatry (01.03.2019)
Published in Molecular psychiatry (01.03.2019)
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Journal Article
Identification of brain aging subtypes in multiple brain regions from cognitively normal individuals
Peng, Shouneng, Haure‐Mirande, Jean‐Vianney, Wang, Minghui, Huffman, Derek M, Haroutunian, Vahram, Ehrlich, Michelle E., Zhang, Bin, Tu, Zhidong
Published in Alzheimer's & dementia (01.06.2023)
Published in Alzheimer's & dementia (01.06.2023)
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Journal Article
Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral A[beta] amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing A[beta] burden
Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben
Published in Molecular psychiatry (01.03.2019)
Published in Molecular psychiatry (01.03.2019)
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Journal Article
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral A[beta] amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing A[beta] burden
Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben
Published in Molecular psychiatry (01.03.2019)
Published in Molecular psychiatry (01.03.2019)
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Journal Article
BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy
Perez-Garcia, Georgina, Bicak, Mesude, Haure-Mirande, Jean-Vianney, Perez, Gissel M., Otero-Pagan, Alena, Gama Sosa, Miguel A., De Gasperi, Rita, Sano, Mary, Barlow, Carrolee, Gage, Fred H., Readhead, Benjamin, Ehrlich, Michelle E., Gandy, Sam, Elder, Gregory A.
Published in Neuroscience letters (16.02.2023)
Published in Neuroscience letters (16.02.2023)
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Journal Article