Genetically modified live vaccine offers protective immunity against wild-type Anaplasma marginale tick-transmission challenge
Ferm, Jonathan, Jaworski, Deborah C., Stoll, Ian, Kleinhenz, Michael D., Kocan, Katherine M., Madesh, Swetha, Ferm, Dominica, Liu, Huitao, Fitzwater, Shawna, Schlieper, Alexis, Ganta, Roman R.
Published in Vaccine (24.10.2024)
Published in Vaccine (24.10.2024)
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Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host
McGill, Jodi L, Nair, Arathy D S, Cheng, Chuanmin, Rusk, Rachel A, Jaworski, Deborah C, Ganta, Roman R
Published in PloS one (03.02.2016)
Published in PloS one (03.02.2016)
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Mutations in Ehrlichia chaffeensis Causing Polar Effects in Gene Expression and Differential Host Specificities
Cheng, Chuanmin, Nair, Arathy D S, Jaworski, Deborah C, Ganta, Roman R
Published in PloS one (17.07.2015)
Published in PloS one (17.07.2015)
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Ehrlichia chaffeensis infection in the reservoir host (white-tailed deer) and in an incidental host (dog) is impacted by its prior growth in macrophage and tick cell environments
Nair, Arathy D S, Cheng, Chuanmin, Jaworski, Deborah C, Willard, Lloyd H, Sanderson, Michael W, Ganta, Roman R
Published in PloS one (10.10.2014)
Published in PloS one (10.10.2014)
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Multiple Ehrlichia chaffeensis genes critical for persistent infection in a vertebrate host are identified as nonessential for its growth in the tick vector; Amblyomma americanum
Jaworski, Deborah C, Wang, Ying, Nair, Arathy, Liu, Huitao, Ganta, Roman R
Published in Frontiers in cellular and infection microbiology (27.06.2023)
Published in Frontiers in cellular and infection microbiology (27.06.2023)
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Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with In Vivo Infection Assessment
Wang, Ying, Nair, Arathy D S, Alhassan, Andy, Jaworski, Deborah C, Liu, Huitao, Trinkl, Kathleen, Hove, Paidashe, Ganta, Charan K, Burkhardt, Nicole, Munderloh, Ulrike G, Ganta, Roman R
Published in Infection and immunity (18.09.2020)
Published in Infection and immunity (18.09.2020)
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Targeted mutagenesis in Anaplasma marginale to define virulence and vaccine development against bovine anaplasmosis
Hove, Paidashe, Madesh, Swetha, Nair, Arathy, Jaworski, Deborah, Liu, Huitao, Ferm, Jonathan, Kleinhenz, Michael D, Highland, Margaret A, Curtis, Andrew K, Coetzee, Johann F, Noh, Susan M, Wang, Ying, Genda, Dominica, Ganta, Roman R
Published in PLoS pathogens (01.05.2022)
Published in PLoS pathogens (01.05.2022)
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Journal Article
Long-Term Protective Immunity against Ehrlichia chaffeensis Infection Induced by a Genetically Modified Live Vaccine
Madesh, Swetha, McGill, Jodi, Jaworski, Deborah C, Ferm, Jonathan, Liu, Huitao, Fitzwater, Shawna, Hove, Paidashe, Ferm, Dominica, Nair, Arathy, Knox, Cheyenne A, Alizadeh, Kimia, Thackrah, Ashley, Ganta, Roman R
Published in Vaccines (Basel) (09.08.2024)
Published in Vaccines (Basel) (09.08.2024)
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Journal Article
Attenuated Mutants of Ehrlichia chaffeensis Induce Protection against Wild-Type Infection Challenge in the Reservoir Host and in an Incidental Host
Nair, Arathy D S, Cheng, Chuanmin, Jaworski, Deborah C, Ganta, Suhasini, Sanderson, Michael W, Ganta, Roman R
Published in Infection and immunity (01.07.2015)
Published in Infection and immunity (01.07.2015)
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Journal Article
Targeted and random mutagenesis of Ehrlichia chaffeensis for the identification of genes required for in vivo infection
Cheng, Chuanmin, Nair, Arathy D S, Indukuri, Vijaya V, Gong, Shanzhong, Felsheim, Roderick F, Jaworski, Deborah, Munderloh, Ulrike G, Ganta, Roman R
Published in PLoS pathogens (01.02.2013)
Published in PLoS pathogens (01.02.2013)
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Journal Article
Amblyomma americanum ticks infected with in vitro cultured wild-type and mutants of Ehrlichia chaffeensis are competent to produce infection in naïve deer and dogs
Jaworski, Deborah C, Cheng, Chuanmin, Nair, Arathy D S, Ganta, Roman R
Published in Ticks and tick-borne diseases (01.01.2017)
Published in Ticks and tick-borne diseases (01.01.2017)
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The transcriptome of the lone star tick, Amblyomma americanum, reveals molecular changes in response to infection with the pathogen, Ehrlichia chaffeensis
Kim, Donghun, Jaworski, Deborah C., Cheng, Chuanmin, Nair, Arathy D.S., Ganta, Roman R., Herndon, Nic, Brown, Susan, Park, Yoonseong
Published in Journal of Asia-Pacific entomology (01.09.2018)
Published in Journal of Asia-Pacific entomology (01.09.2018)
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
Heerding, Dirk A, Chan, George, DeWolf, Walter E, Fosberry, Andrew P, Janson, Cheryl A, Jaworski, Deborah D, McManus, Edward, Miller, William H, Moore, Terrance D, Payne, David J, Qiu, Xiayang, Rittenhouse, Stephen F, Slater-Radosti, Courtney, Smith, Ward, Takata, Dennis T, Vaidya, Kalindi S, Yuan, Catherine C.K, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus
Slater-Radosti, Courtney, Van Aller, Glenn, Greenwood, Rebecca, Nicholas, Richard, Keller, Paul M., DeWolf, Walter E., Fan, Frank, Payne, David J., Jaworski, Deborah D.
Published in Journal of antimicrobial chemotherapy (01.07.2001)
Published in Journal of antimicrobial chemotherapy (01.07.2001)
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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, DeWolf, Walter E, Keller, Paul M, Qiu, Xiayang, Janson, Cheryl A, Vaidya, Kalindi, Fosberry, Andrew P, Smyth, Martin G, Jaworski, Deborah D, Slater-Radosti, Courtney, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article
Amblyomma americanum: Specific Uptake of Immunoglobulins into Tick Hemolymph during Feeding
Jasinskas, Algimantas, Jaworski, Deborah C., Barbour, Alan G.
Published in Experimental parasitology (01.12.2000)
Published in Experimental parasitology (01.12.2000)
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