Transmissible amyloid
Tjernberg, L.O., Rising, A., Johansson, J., Jaudzems, K., Westermark, P.
Published in Journal of internal medicine (01.08.2016)
Published in Journal of internal medicine (01.08.2016)
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Engineered Spider Silk Proteins for Biomimetic Spinning of Fibers with Toughness Equal to Dragline Silks
Arndt, Tina, Greco, Gabriele, Schmuck, Benjamin, Bunz, Jessica, Shilkova, Olga, Francis, Juanita, Pugno, Nicola M, Jaudzems, Kristaps, Barth, Andreas, Johansson, Jan, Rising, Anna
Published in Advanced functional materials (01.06.2022)
Published in Advanced functional materials (01.06.2022)
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Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains
Andersson, Marlene, Chen, Gefei, Otikovs, Martins, Landreh, Michael, Nordling, Kerstin, Kronqvist, Nina, Westermark, Per, Jörnvall, Hans, Knight, Stefan, Ridderstråle, Yvonne, Holm, Lena, Meng, Qing, Jaudzems, Kristaps, Chesler, Mitchell, Johansson, Jan, Rising, Anna
Published in PLoS biology (01.08.2014)
Published in PLoS biology (01.08.2014)
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Biomimetic Spider Silk by Crosslinking and Functionalization with Multiarm Polyethylene Glycol
Romaņuks, Viktors, Fridmanis, Jēkabs, Schmuck, Benjamin, Bula, Anna Līna, Lends, Alons, Senkane, Kristine, Leitis, Gundars, Gaidukovs, Sergejs, Smits, Krisjanis, Rising, Anna, Smits, Gints, Jaudzems, Kristaps
Published in Advanced functional materials (23.07.2024)
Published in Advanced functional materials (23.07.2024)
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Efficient protein production inspired by how spiders make silk
Kronqvist, Nina, Sarr, Médoune, Lindqvist, Anton, Nordling, Kerstin, Otikovs, Martins, Venturi, Luca, Pioselli, Barbara, Purhonen, Pasi, Landreh, Michael, Biverstål, Henrik, Toleikis, Zigmantas, Sjöberg, Lisa, Robinson, Carol V., Pelizzi, Nicola, Jörnvall, Hans, Hebert, Hans, Jaudzems, Kristaps, Curstedt, Tore, Rising, Anna, Johansson, Jan
Published in Nature communications (23.05.2017)
Published in Nature communications (23.05.2017)
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Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation
Kronqvist, Nina, Otikovs, Martins, Chmyrov, Volodymyr, Chen, Gefei, Andersson, Marlene, Nordling, Kerstin, Landreh, Michael, Sarr, Médoune, Jörnvall, Hans, Wennmalm, Stefan, Widengren, Jerker, Meng, Qing, Rising, Anna, Otzen, Daniel, Knight, Stefan D., Jaudzems, Kristaps, Johansson, Jan
Published in Nature communications (2014)
Published in Nature communications (2014)
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Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Kumar, Rakesh, Le Marchand, Tanguy, Adam, Laurène, Bobrovs, Raitis, Chen, Gefei, Fridmanis, Jēkabs, Kronqvist, Nina, Biverstål, Henrik, Jaudzems, Kristaps, Johansson, Jan, Pintacuda, Guido, Abelein, Axel
Published in Nature communications (01.02.2024)
Published in Nature communications (01.02.2024)
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High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Abelein, Axel, Chen, Gefei, Kitoka, Kristīne, Aleksis, Rihards, Oleskovs, Filips, Sarr, Médoune, Landreh, Michael, Pahnke, Jens, Nordling, Kerstin, Kronqvist, Nina, Jaudzems, Kristaps, Rising, Anna, Johansson, Jan, Biverstål, Henrik
Published in Scientific reports (14.01.2020)
Published in Scientific reports (14.01.2020)
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Journal Article
The dimerization mechanism of the N-terminal domain of spider silk proteins is conserved despite extensive sequence divergence
Sarr, Médoune, Kitoka, Kristine, Walsh-White, Kellie-Ann, Kaldmäe, Margit, Metlāns, Rimants, Tārs, Kaspar, Mantese, Alessandro, Shah, Dipen, Landreh, Michael, Rising, Anna, Johansson, Jan, Jaudzems, Kristaps, Kronqvist, Nina
Published in The Journal of biological chemistry (01.05.2022)
Published in The Journal of biological chemistry (01.05.2022)
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A spidroin‐derived solubility tag enables controlled aggregation of a designed amyloid protein
Sarr, Médoune, Kronqvist, Nina, Chen, Gefei, Aleksis, Rihards, Purhonen, Pasi, Hebert, Hans, Jaudzems, Kristaps, Rising, Anna, Johansson, Jan
Published in The FEBS journal (01.05.2018)
Published in The FEBS journal (01.05.2018)
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Journal Article
Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
Arndt, Tina, Jaudzems, Kristaps, Shilkova, Olga, Francis, Juanita, Johansson, Mathias, Laity, Peter R., Sahin, Cagla, Chatterjee, Urmimala, Kronqvist, Nina, Barajas-Ledesma, Edgar, Kumar, Rakesh, Chen, Gefei, Strömberg, Roger, Abelein, Axel, Langton, Maud, Landreh, Michael, Barth, Andreas, Holland, Chris, Johansson, Jan, Rising, Anna
Published in Nature communications (15.08.2022)
Published in Nature communications (15.08.2022)
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Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome
Mikolka, Pavol, Kronqvist, Nina, Haegerstrand-Björkman, Marie, Jaudzems, Kristaps, Kosutova, Petra, Kolomaznik, Maros, Saluri, Mihkel, Landreh, Michael, Calkovska, Andrea, Curstedt, Tore, Johansson, Jan
Published in Translational research : the journal of laboratory and clinical medicine (01.12.2023)
Published in Translational research : the journal of laboratory and clinical medicine (01.12.2023)
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Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D
Zogota, Rimants, Kinena, Linda, Withers-Martinez, Chrislaine, Blackman, Michael J., Bobrovs, Raitis, Pantelejevs, Teodors, Kanepe-Lapsa, Iveta, Ozola, Vita, Jaudzems, Kristaps, Suna, Edgars, Jirgensons, Aigars
Published in European journal of medicinal chemistry (01.02.2019)
Published in European journal of medicinal chemistry (01.02.2019)
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Journal Article
Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy
Otikovs, Martins, Andersson, Marlene, Jia, Qiupin, Nordling, Kerstin, Meng, Qing, Andreas, Loren B., Pintacuda, Guido, Johansson, Jan, Rising, Anna, Jaudzems, Kristaps
Published in Angewandte Chemie International Edition (02.10.2017)
Published in Angewandte Chemie International Edition (02.10.2017)
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Journal Article
pH‐Dependent Dimerization of Spider Silk N-Terminal Domain Requires Relocation of a Wedged Tryptophan Side Chain
Jaudzems, Kristaps, Askarieh, Glareh, Landreh, Michael, Nordling, Kerstin, Hedhammar, My, Jörnvall, Hans, Rising, Anna, Knight, Stefan D., Johansson, Jan
Published in Journal of molecular biology (28.09.2012)
Published in Journal of molecular biology (28.09.2012)
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2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity
Rasina, Dace, Stakanovs, Georgijs, Borysov, Oleksandr V., Pantelejevs, Teodors, Bobrovs, Raitis, Kanepe-Lapsa, Iveta, Tars, Kaspars, Jaudzems, Kristaps, Jirgensons, Aigars
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Journal Article
Structural insights into aggregation hotspots on Alzheimer's associated amyloid-β fibrils blocked by the BRICHOS chaperone
Abelein, A, Kumar, R, Le Marchand, T, Adam, L, Chen, GF, Fridmanis, J, Kronqvist, N, Biverstal, H, Jaudzems, K, Johansson, J, Pintacuda, G
Published in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2023)
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Published in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2023)
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