Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, Ergün, Colla, Simona, Liesa, Marc, Moslehi, Javid, Müller, Florian L., Guo, Mira, Cooper, Marcus, Kotton, Darrell, Fabian, Attila J., Walkey, Carl, Maser, Richard S., Tonon, Giovanni, Foerster, Friedrich, Xiong, Robert, Wang, Y. Alan, Shukla, Sachet A., Jaskelioff, Mariela, Martin, Eric S., Heffernan, Timothy P., Protopopov, Alexei, Ivanova, Elena, Mahoney, John E., Kost-Alimova, Maria, Perry, Samuel R., Bronson, Roderick, Liao, Ronglih, Mulligan, Richard, Shirihai, Orian S., Chin, Lynda, DePinho, Ronald A.
Published in Nature (London) (17.02.2011)
Published in Nature (London) (17.02.2011)
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Journal Article
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2014)
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Journal Article
Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes
Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Vande Woude, George, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda
Published in Cancer cell (12.07.2011)
Published in Cancer cell (12.07.2011)
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Journal Article
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, Mariela, Muller, Florian L., Paik, Ji-Hye, Thomas, Emily, Jiang, Shan, Adams, Andrew C., Sahin, Ergun, Kost-Alimova, Maria, Protopopov, Alexei, Cadiñanos, Juan, Horner, James W., Maratos-Flier, Eleftheria, DePinho, Ronald A.
Published in Nature (London) (06.01.2011)
Published in Nature (London) (06.01.2011)
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Journal Article
LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors
Monaco, Kelli-Ann, Delach, Scott, Yuan, Jing, Mishina, Yuji, Fordjour, Paul, Labrot, Emma, McKay, Daniel, Guo, Ribo, Higgins, Stacy, Wang, Hui Qin, Liang, Jinsheng, Bui, Karen, Green, John, Aspesi, Peter, Ambrose, Jessi, Mapa, Felipa, Griner, Lesley, Jaskelioff, Mariela, Fuller, John, Crawford, Kenneth, Pardee, Gwynn, Widger, Stephania, Hammerman, Peter S, Engelman, Jeffrey A, Stuart, Darrin D, Cooke, Vesselina G, Caponigro, Giordano
Published in Clinical cancer research (01.04.2021)
Published in Clinical cancer research (01.04.2021)
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Journal Article
Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma
Leung, Grace P, Feng, Tianshu, Sigoillot, Frederic D, Geyer, Felipe C, Shirley, Matthew D, Ruddy, David A, Rakiec, Daniel P, Freeman, Alyson K, Engelman, Jeffrey A, Jaskelioff, Mariela, Stuart, Darrin D
Published in Molecular cancer research (01.01.2019)
Published in Molecular cancer research (01.01.2019)
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Journal Article
Abstract LB-114: RAF inhibitor LXH254 effectively inhibits B-and-CRAF, but not ARAF
Monaco, Kelli-Ann, Delach, Scott, Fordjour, Paul, Parikh, Salonee, Feng, Yun, Jaskelioff, Mariela, Stuart, Darrin, Caponigro, Giordano
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases
Ding, Zhihu, Wu, Chang-Jiun, Jaskelioff, Mariela, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Chu, Gerald C., Wang, Guocan, Lu, Xin, Labrot, Emma S., Hu, Jian, Wang, Wei, Xiao, Yonghong, Zhang, Hailei, Zhang, Jianhua, Zhang, Jingfang, Gan, Boyi, Perry, Samuel R., Jiang, Shan, Li, Liren, Horner, James W., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Published in Cell (02.03.2012)
Published in Cell (02.03.2012)
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Journal Article
Abstract 965: Deleterious effects of MAPK pathway hyperactivation in BRAF-mutant melanoma
Leung, Grace P., Feng, Tianshu, Shirley, Matthew D., Sigoillot, Frederic D., Ruddy, David A., Freeman, Alyson K., Jaskelioff, Mariela, Stuart, Darrin D.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
Hu, Jian, Hwang, Soyoon Sarah, Liesa, Marc, Gan, Boyi, Sahin, Ergun, Jaskelioff, Mariela, Ding, Zhihu, Ying, Haoqiang, Boutin, Adam T., Zhang, Hailei, Johnson, Shawn, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Wang, Yaoqi Alan, Shirihai, Orian S., Chin, Lynda, DePinho, Ronald A.
Published in Cell (17.02.2012)
Published in Cell (17.02.2012)
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Journal Article
Abstract 444: BRM/SMARCA2 is a critical synthetic lethal target in BRG1-deficient cancers
Jaskelioff, Mariela, Hoffman, Gregory, Rahal, Rami, Xiang, Kay, Haas, Kristy, Saenz-Vash, Veronica, Zhai, Huili, Keen, Nicholas, Stegmeier, Frank, Jagani, Zainab
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer
Shingu, Takashi, Jaskelioff, Mariela, Yuan, Liang, Ding, Zhihu, Protopopov, Alexei, Kost-Alimova, Maria, Hu, Jian
Published in Journal of visualized experiments (13.04.2015)
Published in Journal of visualized experiments (13.04.2015)
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Journal Article
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Shingu, Takashi, Jaskelioff, Mariela, Yuan, Liang, Ding, Zhihu, Protopopov, Alexei, Kost-Alimova, Maria, Hu, Jian
Published in Journal of visualized experiments (13.04.2015)
Published in Journal of visualized experiments (13.04.2015)
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Journal Article
Chromatin and transcription: histones continue to make their marks
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Journal Article
Conference Proceeding
Abstract PR06: A functional screen of the epigenome identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Jagani, Zainab, Hoffman, Gregory, Rahal, Rami, Buxton, Frank, McAllister, Gregory, Xiang, Kay, Frias, Elizabeth, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Bagdasarian, Linda, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris, Meyer, Matthew, McLaughlin, Margaret E., Roberts, Charles WM, Myer, Vic, Porter, Jeff, Keen, Nicholas, Mickanin, Craig, Stegmeier, Frank
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Genome unstable murine prostate cancers acquire genomic aberrations and bone metastatic features of the human disease
Ding, Zhihu, Wu, Chang-Jiun, Jaskelioff, Mariela, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Chu, Gerald C., Wang, Guocan, Lu, Xin, Labrot, Emma S., Hu, Jian, Wang, Wei, Xiao, Yonghong, Zhang, Hailei, Zhang, Jianhua, Zhang, Jingfang, Gan, Boyi, Perry, Samuel R., Jiang, Shan, Li, Liren, Horner, James W., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Published in Cell (02.03.2012)
Published in Cell (02.03.2012)
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