Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
Tao, Yuyong, Mis, Monika, Blazer, Levi, Ustav, Jnr, Mart, Steinhart, Zachary, Chidiac, Rony, Kubarakos, Elli, O'Brien, Siobhan, Wang, Xiaomei, Jarvik, Nick, Patel, Nish, Adams, Jarrett, Moffat, Jason, Angers, Stephane, Sidhu, Sachdev S
Published in eLife (27.08.2019)
Published in eLife (27.08.2019)
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Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning
Wildenhain, Jan, Spitzer, Michaela, Dolma, Sonam, Jarvik, Nick, White, Rachel, Roy, Marcia, Griffiths, Emma, Bellows, David S., Wright, Gerard D., Tyers, Mike
Published in Cell systems (23.12.2015)
Published in Cell systems (23.12.2015)
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Prediction and experimental characterization of nsSNPs altering human PDZ-binding motifs
Gfeller, David, Ernst, Andreas, Jarvik, Nick, Sidhu, Sachdev S, Bader, Gary D
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins
McCluskey, Andrew J, Bolewska-Pedyczak, Eleonora, Jarvik, Nick, Chen, Gang, Sidhu, Sachdev S, Gariépy, Jean
Published in PloS one (15.02.2012)
Published in PloS one (15.02.2012)
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Journal Article
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
Wildenhain, Jan, Spitzer, Michaela, Dolma, Sonam, Jarvik, Nick, White, Rachel, Roy, Marcia, Griffiths, Emma, Bellows, David S., Wright, Gerard D., Tyers, Mike
Published in Scientific data (22.11.2016)
Published in Scientific data (22.11.2016)
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Structural and functional validation of a highly specific Smurf2 inhibitor
Tessier, Tanner M., Chowdhury, Arvid, Stekel, Zane, Fux, Julia, Sartori, Maria Augusta, Teyra, Joan, Jarvik, Nick, Chung, Jacky, Kurinov, Igor, Sicheri, Frank, Sidhu, Sachdev S., Singer, Alex U., Zhang, Wei
Published in Protein science (01.02.2024)
Published in Protein science (01.02.2024)
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Journal Article
Site-Specific Conjugation of Metal-Chelating Polymers to Anti-Frizzled‑2 Antibodies via Microbial Transglutaminase
Le, Penny J, Miersch, Shane, Forbes, Matthew W, Jarvik, Nick, Ku, Anthony, Sidhu, Sachdev S, Reilly, Raymond M, Winnik, Mitchell A
Published in Biomacromolecules (14.06.2021)
Published in Biomacromolecules (14.06.2021)
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Journal Article
A Short DNA Aptamer That Recognizes TNFα and Blocks Its Activity in Vitro
Orava, Erik W, Jarvik, Nick, Shek, Yuen Lai, Sidhu, Sachdev S, Gariépy, Jean
Published in ACS chemical biology (18.01.2013)
Published in ACS chemical biology (18.01.2013)
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Journal Article
Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor
Chen, Gang, Karauzum, Hatice, Long, Hua, Carranza, Danielle, Holtsberg, Frederick W., Howell, Katie A., Abaandou, Laura, Zhang, Bojie, Jarvik, Nick, Ye, Wei, Liao, Grant C., Gross, Michael L., Leung, Daisy W., Amarasinghe, Gaya K., Aman, M. Javad, Sidhu, Sachdev S.
Published in Journal of molecular biology (04.10.2019)
Published in Journal of molecular biology (04.10.2019)
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Journal Article
A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
Pavlovic, Zvezdan, Adams, Jarrett J, Blazer, Levi L, Gakhal, Amandeep K, Jarvik, Nick, Steinhart, Zachary, Robitaille, Mélanie, Mascall, Keith, Pan, James, Angers, Stephane, Moffat, Jason, Sidhu, Sachdev S
Published in mAbs (17.11.2018)
Published in mAbs (17.11.2018)
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Journal Article
Selection of recombinant anti‐SH3 domain antibodies by high‐throughput phage display
Huang, Haiming, Economopoulos, Nicolas O., Liu, Bernard A., Uetrecht, Andrea, Gu, Jun, Jarvik, Nick, Nadeem, Vincent, Pawson, Tony, Moffat, Jason, Miersch, Shane, Sidhu, Sachdev S.
Published in Protein science (01.11.2015)
Published in Protein science (01.11.2015)
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Journal Article
Selection of recombinant anti‐ SH 3 domain antibodies by high‐throughput phage display
Huang, Haiming, Economopoulos, Nicolas O., Liu, Bernard A., Uetrecht, Andrea, Gu, Jun, Jarvik, Nick, Nadeem, Vincent, Pawson, Tony, Moffat, Jason, Miersch, Shane, Sidhu, Sachdev S.
Published in Protein science (01.11.2015)
Published in Protein science (01.11.2015)
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Journal Article
Prediction of compound synergism from chemical-genetic interactions by machine learning
Wildenhain, Jan, Spitzer, Michaela, Dolma, Sonam, Bellows, David, Jarvik, Nick, White, Rachel, Roy, Marcia, Griffiths, Emma, Wright, Gerard D., Tyers, Mike
Published in Cell systems (23.12.2015)
Published in Cell systems (23.12.2015)
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Journal Article
A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
Pavlovic, Zvezdan, Adams, Jarrett J., Blazer, Levi L., Gakhal, Amandeep K., Jarvik, Nick, Steinhart, Zachary, Robitaille, Mélanie, Mascall, Keith, Pan, James, Angers, Stephane, Moffat, Jason, Sidhu, Sachdev S.
Published in mAbs (17.11.2018)
Published in mAbs (17.11.2018)
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