Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases
Forrest, Andrew K., Jarvest, Richard L., Mensah, Lucy M., O'Hanlon, Peter J., Pope, Andrew J., Sheppard, Robert J.
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones
Jarvest, Richard L., Pinto, Ivan L., Ashman, Stephen M., Dabrowski, Christine E., Fernandez, Annabellee V., Jennings, L.John, Lavery, Patrick, Tew, David G.
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
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Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors
Qiu, Xiayang, Janson, Cheryl A., Smith, Ward W., Green, Susan M., McDevitt, Patrick, Johanson, Kyung, Carter, Paul, Hibbs, Martin, Lewis, Ceri, Chalker, Alison, Fosberry, Andrew, Lalonde, Judith, Berge, John, Brown, Pamela, Houge‐Frydrych, Catherine S.V., Jarvest, Richard L.
Published in Protein science (01.10.2001)
Published in Protein science (01.10.2001)
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Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]
VERE HODGE, R. A, SUTTON, D, BOYD, M. R, HARNDEN, M. R, JARVEST, R. L
Published in Antimicrobial Agents and Chemotherapy (01.10.1989)
Published in Antimicrobial Agents and Chemotherapy (01.10.1989)
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[594] GSK625433; A NOVEL AND HIGHLY POTENT INHIBITOR OF THE HCV NS5B POLYMERASE
Gray, F, Amphlett, E, Bright, H, Chambers, L, Cheasty, A, Fenwick, R, Haigh, D, Hartley, D, Howes, P, Jarvest, R, Mirzai, F, Nerozzi, F, Parry, N, Slater, M, Smith, S, Thommes, P, Wilkinson, C, Williams, E
Published in Journal of hepatology (2007)
Published in Journal of hepatology (2007)
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes
GENTRY, Daniel R, INGRAHAM, Karen A, STANHOPE, Michael J, RITTENHOUSE, Stephen, JARVEST, Richard L, O'HANLON, Peter J, BROWN, James R, HOLMES, David J
Published in Antimicrobial Agents and Chemotherapy (01.06.2003)
Published in Antimicrobial Agents and Chemotherapy (01.06.2003)
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Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands
Champness, John N., Bennett, Matthew S., Wien, Frank, Visse, Rob, Summers, William C., Herdewijn, Piet, de Clercq, Erik, Ostrowski, Tomasz, Jarvest, Richard L., Sanderson, Mark R.
Published in Proteins, structure, function, and bioinformatics (15.08.1998)
Published in Proteins, structure, function, and bioinformatics (15.08.1998)
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Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383
Berge, John M, Copley, Royston C.B, Eggleston, Drake S, Hamprecht, Dieter W, Jarvest, Richard L, Mensah, Lucy M, O'Hanlon, Peter J, Pope, Andrew J
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism
Pinto, Ivan L., Jarvest, Richard L., Clarke, Brian, Dabrowski, Christine E., Fenwick, Ashley, Gorczyca, Michele M, Jennings, L.John, Lavery, Patrick, Sternberg, Edmund J, Tew, David G., West, Andrew
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
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Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines
Harnden, Michael R., Jarvest, Richard L., Bacon, Teresa H., Boyd, Malcolm R.
Published in Journal of medicinal chemistry (01.09.1987)
Published in Journal of medicinal chemistry (01.09.1987)
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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase
BERGE, JOHN M., BROOM, NIGEL J. P., HOUGE-FRYDRYCH, CATHERINE S. V., JARVEST, RICHARD L., MENSAH, LUCY, MCNAIR, DAVID J., O'HANLON, PETER J., POPE, ANDREW J., RITTENHOUSE, STEPHEN
Published in Journal of antibiotics (01.11.2000)
Published in Journal of antibiotics (01.11.2000)
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Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: Inhibition and crystal structure of a complex
Jarvest, Richard L., Berge, John M., Houge-Frydrych, Catherine S.V., Janson, Cheryl, Mensah, Lucy M., O'Hanlon, Peter J., Pope, Andrew, Saldanha, Adrian, Xiayang Qiu
Published in Bioorganic & medicinal chemistry letters (04.10.1999)
Published in Bioorganic & medicinal chemistry letters (04.10.1999)
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Characterization of the Nucleotide and DNA Coeffector Binding Sites of the Herpes Simplex Virus Type 1 (HSV-1) Encoded Helicase-Primase Complex and UL9 Origin Binding Protein
Earnshaw, D.L., Jarvest, R.L.
Published in Biochemical and biophysical research communications (30.03.1994)
Published in Biochemical and biophysical research communications (30.03.1994)
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Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties
Harnden, Michael R, Jarvest, Richard L, Boyd, Malcolm R, Sutton, David, Vere Hodge, R. Anthony
Published in Journal of medicinal chemistry (01.08.1989)
Published in Journal of medicinal chemistry (01.08.1989)
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Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase
Brown, Pamela, Eggleston, Drake S., Haltiwanger, R.Curtis, Jarvest, Richard L., Mensah, Lucy, O'Hanlon, Peter J., Pope, Andrew J.
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383
Jarvest, Richard L, Berge, John M, Brown, Pamela, Hamprecht, Dieter W, McNair, David J, Mensah, Lucy, O'Hanlon, Peter J, Pope, Andrew J
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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