Organoid culture systems for prostate epithelial and cancer tissue
Drost, Jarno, Karthaus, Wouter R, Gao, Dong, Driehuis, Else, Sawyers, Charles L, Chen, Yu, Clevers, Hans
Published in Nature protocols (01.02.2016)
Published in Nature protocols (01.02.2016)
Get full text
Journal Article
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Get full text
Journal Article
A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression
Fumagalli, Arianna, Suijkerbuijk, Saskia J E, Begthel, Harry, Beerling, Evelyne, Oost, Koen C, Snippert, Hugo J, van Rheenen, Jacco, Drost, Jarno
Published in Nature protocols (01.02.2018)
Published in Nature protocols (01.02.2018)
Get full text
Journal Article
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M., Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P. A., van den Heuvel-Eibrink, Marry M., Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, Clevers, Hans
Published in Nature biotechnology (01.03.2019)
Published in Nature biotechnology (01.03.2019)
Get full text
Journal Article
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, Gerwen, Bastiaan van, van der Ven, Marieke, Wetering, Marc van de, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Published in eLife (15.11.2016)
Published in eLife (15.11.2016)
Get full text
Journal Article
Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
Karthaus, Wouter R., Iaquinta, Phillip J., Drost, Jarno, Gracanin, Ana, van Boxtel, Ruben, Wongvipat, John, Dowling, Catherine M., Gao, Dong, Begthel, Harry, Sachs, Norman, Vries, Robert G.J., Cuppen, Edwin, Chen, Yu, Sawyers, Charles L., Clevers, Hans C.
Published in Cell (25.09.2014)
Published in Cell (25.09.2014)
Get full text
Journal Article
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids
Fumagalli, Arianna, Drost, Jarno, Suijkerbuijk, Saskia J. E., van Boxtel, Ruben, de Ligt, Joep, Offerhaus, G. Johan, Begthel, Harry, Beerling, Evelyne, Tan, Ee Hong, Sansom, Owen J., Cuppen, Edwin, Clevers, Hans, van Rheenen, Jacco
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2017)
Get full text
Journal Article
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H. D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A. M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C. P., Clevers, Hans, Drost, Jarno
Published in Nature communications (11.03.2020)
Published in Nature communications (11.03.2020)
Get full text
Journal Article
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
Custers, Lars, Khabirova, Eleonora, Coorens, Tim H. H., Oliver, Thomas R. W., Calandrini, Camilla, Young, Matthew D., Vieira Braga, Felipe A., Ellis, Peter, Mamanova, Lira, Segers, Heidi, Maat, Arie, Kool, Marcel, Hoving, Eelco W., van den Heuvel-Eibrink, Marry M., Nicholson, James, Straathof, Karin, Hook, Liz, de Krijger, Ronald R., Trayers, Claire, Allinson, Kieren, Behjati, Sam, Drost, Jarno
Published in Nature communications (03.03.2021)
Published in Nature communications (03.03.2021)
Get full text
Journal Article
p53 induces transcriptional and translational programs to suppress cell proliferation and growth
Loayza-Puch, Fabricio, Drost, Jarno, Rooijers, Koos, Lopes, Rui, Elkon, Ran, Agami, Reuven
Published in Genome biology (17.04.2013)
Published in Genome biology (17.04.2013)
Get full text
Journal Article
The Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites
Jenal, Mathias, Elkon, Ran, Loayza-Puch, Fabricio, van Haaften, Gijs, Kühn, Uwe, Menzies, Fiona M., Vrielink, Joachim A.F. Oude, Bos, Arnold J., Drost, Jarno, Rooijers, Koos, Rubinsztein, David C., Agami, Reuven
Published in Cell (27.04.2012)
Published in Cell (27.04.2012)
Get full text
Journal Article
SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors
Liu, Ning Qing, Paassen, Irene, Custers, Lars, Zeller, Peter, Teunissen, Hans, Ayyildiz, Dilara, He, Jiayou, Buhl, Juliane Laura, Hoving, Eelco Wieger, van Oudenaarden, Alexander, de Wit, Elzo, Drost, Jarno
Published in Nature communications (01.12.2023)
Published in Nature communications (01.12.2023)
Get full text
Journal Article
The Generation of Organoids for Studying Wnt Signaling
Drost, Jarno, Artegiani, Benedetta, Clevers, Hans
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2016)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2016)
Get more information
Journal Article
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype
Fessler, Evelyn, Drost, Jarno, van Hooff, Sander R, Linnekamp, Janneke F, Wang, Xin, Jansen, Marnix, De Sousa E Melo, Felipe, Prasetyanti, Pramudita R, IJspeert, Joep EG, Franitza, Marek, Nürnberg, Peter, van Noesel, Carel JM, Dekker, Evelien, Vermeulen, Louis, Clevers, Hans, Medema, Jan Paul
Published in EMBO molecular medicine (01.07.2016)
Published in EMBO molecular medicine (01.07.2016)
Get full text
Journal Article
A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors
Voorhoeve, P. Mathijs, le Sage, Carlos, Schrier, Mariette, Gillis, Ad J.M., Stoop, Hans, Nagel, Remco, Liu, Ying-Poi, van Duijse, Josyanne, Drost, Jarno, Griekspoor, Alexander, Zlotorynski, Eitan, Yabuta, Norikazu, De Vita, Gabriella, Nojima, Hiroshi, Looijenga, Leendert H.J., Agami, Reuven
Published in Cell (24.03.2006)
Published in Cell (24.03.2006)
Get full text
Journal Article
Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma
DeMartino, Jeff, Meister, Michael T., Visser, Lindy L., Brok, Mariël, Groot Koerkamp, Marian J. A., Wezenaar, Amber K. L., Hiemcke-Jiwa, Laura S., de Souza, Terezinha, Merks, Johannes H. M., Rios, Anne C., Holstege, Frank C. P., Margaritis, Thanasis, Drost, Jarno
Published in Nature communications (27.05.2023)
Published in Nature communications (27.05.2023)
Get full text
Journal Article
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
Calandrini, Camilla, van Hooff, Sander R., Paassen, Irene, Ayyildiz, Dilara, Derakhshan, Sepide, Dolman, M. Emmy M., Langenberg, Karin P.S., van de Ven, Marieke, de Heus, Cecilia, Liv, Nalan, Kool, Marcel, de Krijger, Ronald R., Tytgat, Godelieve A.M., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., Drost, Jarno
Published in Cell reports (Cambridge) (24.08.2021)
Published in Cell reports (Cambridge) (24.08.2021)
Get full text
Journal Article