Consecutive Aromatic Residues Are Required for Improved Efficacy of β-Sheet Breakers
Jarmuła, Adam, Zubalska, Monika, Stępkowski, Dariusz
Published in International journal of molecular sciences (08.05.2022)
Published in International journal of molecular sciences (08.05.2022)
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Journal Article
Molecular Mechanism of Thymidylate Synthase Inhibition by N4-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies
Maj, Piotr, Jarmuła, Adam, Wilk, Piotr, Prokopowicz, Małgorzata, Rypniewski, Wojciech, Zieliński, Zbigniew, Dowierciał, Anna, Bzowska, Agnieszka, Rode, Wojciech
Published in International journal of molecular sciences (30.04.2021)
Published in International journal of molecular sciences (30.04.2021)
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Journal Article
Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues
Prokopowicz, Małgorzata, Jarmuła, Adam, Casamayou-Boucau, Yannick, Gordon, Fiona, Ryder, Alan, Sobich, Justyna, Maj, Piotr, Cieśla, Joanna, Zieliński, Zbigniew, Fita, Piotr, Rode, Wojciech
Published in International journal of molecular sciences (06.03.2021)
Published in International journal of molecular sciences (06.03.2021)
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Journal Article
Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N 4 -hydroxy-dCMP
Ludwiczak, Jan, Maj, Piotr, Wilk, Piotr, Frączyk, Tomasz, Ruman, Tomasz, Kierdaszuk, Borys, Jarmuła, Adam, Rode, Wojciech
Published in Molecular bioSystems (2016)
Published in Molecular bioSystems (2016)
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Journal Article
Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells
Antosiewicz, Anna, Jarmuła, Adam, Przybylska, Dorota, Mosieniak, Grażyna, Szczepanowska, Joanna, Kowalkowska, Anna, Rode, Wojciech, Cieśla, Joanna
Published in Journal of biomolecular structure & dynamics (19.05.2017)
Published in Journal of biomolecular structure & dynamics (19.05.2017)
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Journal Article
Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations
Dowierciał, Anna, Wilk, Piotr, Rypniewski, Wojciech, Rode, Wojciech, Jarmuła, Adam
Published in BioMed research international (01.01.2014)
Published in BioMed research international (01.01.2014)
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Journal Article
Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
Dowierciał, Anna, Jarmuła, Adam, Wilk, Piotr, Rypniewski, Wojciech, Kowalska, Monika, Frączyk, Tomasz, Cieśla, Joanna, Rode, Wojciech
Published in Structural chemistry (01.06.2017)
Published in Structural chemistry (01.06.2017)
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Journal Article
Properties of phosphorylated thymidylate synthase
Frączyk, Tomasz, Ruman, Tomasz, Wilk, Piotr, Palmowski, Paweł, Rogowska-Wrzesinska, Adelina, Cieśla, Joanna, Zieliński, Zbigniew, Nizioł, Joanna, Jarmuła, Adam, Maj, Piotr, Gołos, Barbara, Wińska, Patrycja, Ostafil, Sylwia, Wałajtys-Rode, Elżbieta, Shugar, David, Rode, Wojciech
Published in Biochimica et biophysica acta (01.12.2015)
Published in Biochimica et biophysica acta (01.12.2015)
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Journal Article
Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies
Maj, Piotr, Jarmuła, Adam, Wilk, Piotr, Prokopowicz, Małgorzata, Rypniewski, Wojciech, Zieliński, Zbigniew, Dowierciał, Anna, Bzowska, Agnieszka, Rode, Wojciech
Published in International journal of molecular sciences (01.05.2021)
Published in International journal of molecular sciences (01.05.2021)
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Journal Article
Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS
Jarmuła, Adam, Wilk, Piotr, Maj, Piotr, Ludwiczak, Jan, Dowierciał, Anna, Banaszak, Katarzyna, Rypniewski, Wojciech, Cieśla, Joanna, Dąbrowska, Magdalena, Frączyk, Tomasz, Bronowska, Agnieszka K., Jakowiecki, Jakub, Filipek, Sławomir, Rode, Wojciech
Published in Journal of molecular graphics & modelling (01.10.2017)
Published in Journal of molecular graphics & modelling (01.10.2017)
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Journal Article
Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer
Wilk, Piotr, Jarmuła, Adam, Ruman, Tomasz, Banaszak, Katarzyna, Rypniewski, Wojciech, Cieśla, Joanna, Dowierciał, Anna, Rode, Wojciech
Published in Bioorganic chemistry (01.02.2014)
Published in Bioorganic chemistry (01.02.2014)
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Journal Article
ANO5 mutations in the Polish limb girdle muscular dystrophy patients: Effects on the protein structure
Jarmula, Adam, Łusakowska, Anna, Fichna, Jakub P., Topolewska, Malgorzata, Macias, Anna, Johnson, Katherine, Töpf, Ana, Straub, Volker, Rosiak, Edyta, Szczepaniak, Krzysztof, Dunin-Horkawicz, Stanisław, Maruszak, Aleksandra, Kaminska, Anna M., Redowicz, Maria Jolanta
Published in Scientific reports (08.08.2019)
Published in Scientific reports (08.08.2019)
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