Does In Vitro Potency Predict Clinically Efficacious Concentrations?
Jansson‐Löfmark, Rasmus, Hjorth, Stephan, Gabrielsson, Johan
Published in Clinical pharmacology and therapeutics (01.08.2020)
Published in Clinical pharmacology and therapeutics (01.08.2020)
Get full text
Journal Article
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell
Knerr, Laurent, Prakash, Thazha P, Lee, Richard, Drury III, William J, Nikan, Mehran, Fu, Wuxia, Pirie, Elaine, Maria, Leonardo De, Valeur, Eric, Hayen, Ahlke, Ölwegård-Halvarsson, Maria, Broddefalk, Johan, Ämmälä, Carina, Østergaard, Michael E, Meuller, Johan, Sundström, Linda, Andersson, Patrik, Janzén, David, Jansson-Löfmark, Rasmus, Seth, Punit P, Andersson, Shalini
Published in Journal of the American Chemical Society (10.03.2021)
Published in Journal of the American Chemical Society (10.03.2021)
Get full text
Journal Article
Oral Drug Dosing After Gastric Bypass and Diet‐Induced Weight Loss: Simpler Than We Think? Lessons Learned From the COCKTAIL Study
Kvitne, Kine Eide, Hjelmesæth, Jøran, Hovd, Markus, Sandbu, Rune, Johnson, Line Kristin, Andersson, Shalini, Karlsson, Cecilia, Christensen, Hege, Jansson‐Löfmark, Rasmus, Åsberg, Anders, Robertsen, Ida
Published in Clinical pharmacology and therapeutics (01.09.2024)
Published in Clinical pharmacology and therapeutics (01.09.2024)
Get full text
Journal Article
Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
Wegler, Christine, Wiśniewski, Jacek R., Robertsen, Ida, Christensen, Hege, Kristoffer Hertel, Jens, Hjelmesæth, Jøran, Jansson‐Löfmark, Rasmus, Åsberg, Anders, Andersson, Tommy B., Artursson, Per
Published in Clinical pharmacology and therapeutics (01.05.2022)
Published in Clinical pharmacology and therapeutics (01.05.2022)
Get full text
Journal Article
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion
Bamberg, Krister, Johansson, Ulrika, Edman, Karl, William-Olsson, Lena, Myhre, Susanna, Gunnarsson, Anders, Geschwindner, Stefan, Aagaard, Anna, Björnson Granqvist, Anna, Jaisser, Frédéric, Huang, Yufeng, Granberg, Kenneth L, Jansson-Löfmark, Rasmus, Hartleib-Geschwindner, Judith
Published in PloS one (23.02.2018)
Published in PloS one (23.02.2018)
Get full text
Journal Article
Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight
Wegler, Christine, Prieto Garcia, Luna, Klinting, Signe, Robertsen, Ida, Wiśniewski, Jacek R., Hjelmesæth, Jøran, Åsberg, Anders, Jansson‐Löfmark, Rasmus, Andersson, Tommy B., Artursson, Per
Published in Clinical pharmacology and therapeutics (01.03.2021)
Published in Clinical pharmacology and therapeutics (01.03.2021)
Get full text
Journal Article
Population Pharmacodynamic Modeling of Eflornithine-Based Treatments Against Late-Stage Gambiense Human African Trypanosomiasis and Efficacy Predictions of L-eflornithine-Based Therapy
Amilon, Carl, Boberg, Mikael, Tarning, Joel, Äbelö, Angela, Ashton, Michael, Jansson-Löfmark, Rasmus
Published in The AAPS journal (25.03.2022)
Published in The AAPS journal (25.03.2022)
Get full text
Journal Article
Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S]
Sokolov, Victor, Helmlinger, Gabriel, Nilsson, Catarina, Zhudenkov, Kirill, Skrtic, Stanko, Hamrén, Bengt, Peskov, Kirill, Hurt-Camejo, Eva, Jansson-Löfmark, Rasmus
Published in Journal of lipid research (01.09.2019)
Published in Journal of lipid research (01.09.2019)
Get full text
Journal Article
Enantiospecific antitrypanosomal in vitro activity of eflornithine
Boberg, Mikael, Cal, Monica, Kaiser, Marcel, Jansson-Löfmark, Rasmus, Mäser, Pascal, Ashton, Michael
Published in PLoS neglected tropical diseases (01.07.2021)
Published in PLoS neglected tropical diseases (01.07.2021)
Get full text
Journal Article
Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
Kvitne, Kine Eide, Hovd, Markus, Johnson, Line Kristin, Wegler, Christine, Karlsson, Cecilia, Artursson, Per, Andersson, Shalini, Sandbu, Rune, Hjelmesæth, Jøran, Skovlund, Eva, Jansson-Löfmark, Rasmus, Christensen, Hege, Åsberg, Anders, Robertsen, Ida
Published in Clinical pharmacokinetics (01.01.2024)
Published in Clinical pharmacokinetics (01.01.2024)
Get full text
Journal Article
Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial
Kvitne, Kine Eide, Robertsen, Ida, Skovlund, Eva, Christensen, Hege, Krogstad, Veronica, Wegler, Christine, Angeles, Philip Carlo, Wollmann, Birgit Malene, Hole, Kristine, Johnson, Line Kristin, Sandbu, Rune, Artursson, Per, Karlsson, Cecilia, Andersson, Shalini, Andersson, Tommy B., Hjelmesæth, Jøran, Jansson‐Löfmark, Rasmus, Åsberg, Anders
Published in Clinical and translational science (01.01.2022)
Published in Clinical and translational science (01.01.2022)
Get full text
Journal Article
Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator
Erlandsson, Fredrik, Albayaty, Muna, Chialda, Ligia, Ericsson, Hans, Amilon, Carl, Nelander, Karin, Jansson‐Löfmark, Rasmus, Wernevik, Linda, Kjaer, Magnus, Bamberg, Krister, Hartleib‐Geschwindner, Judith
Published in British journal of clinical pharmacology (01.07.2018)
Published in British journal of clinical pharmacology (01.07.2018)
Get full text
Journal Article
A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II
Knöchel, Jane, Nilsson, Catarina, Carlsson, Björn, Wernevik, Linda, Hofherr, Alexis, Gennemark, Peter, Jansson‐Löfmark, Rasmus, Isaksson, Rikard, Rydén‐Bergsten, Tina, Hamrén, Bengt, Rekić, Dinko
Published in CPT: pharmacometrics and systems pharmacology (01.12.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.12.2022)
Get full text
Journal Article
Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity
Kvitne, Kine Eide, Åsberg, Anders, Johnson, Line K., Wegler, Christine, Hertel, Jens K., Artursson, Per, Karlsson, Cecilia, Andersson, Shalini, Sandbu, Rune, Skovlund, Eva, Christensen, Hege, Jansson‐Löfmark, Rasmus, Hjelmesæth, Jøran, Robertsen, Ida
Published in Clinical and translational science (01.11.2022)
Published in Clinical and translational science (01.11.2022)
Get full text
Journal Article
The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone
Bamberg, Krister, William-Olsson, Lena, Johansson, Ulrika, Jansson-Löfmark, Rasmus, Hartleib-Geschwindner, Judith
Published in Journal of the renin-angiotensin-aldosterone system (01.01.2019)
Published in Journal of the renin-angiotensin-aldosterone system (01.01.2019)
Get full text
Journal Article
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection
Granberg, Kenneth L, Yuan, Zhong-Qing, Lindmark, Bo, Edman, Karl, Kajanus, Johan, Hogner, Anders, Malmgren, Marcus, O’Mahony, Gavin, Nordqvist, Anneli, Lindberg, Jan, Tångefjord, Stefan, Kossenjans, Michael, Löfberg, Christian, Brånalt, Jonas, Liu, Dongmei, Selmi, Nidhal, Nikitidis, Grigorios, Nordberg, Peter, Hayen, Ahlke, Aagaard, Anna, Hansson, Eva, Hermansson, Majlis, Ivarsson, Ida, Jansson-Löfmark, Rasmus, Karlsson, Ulla, Johansson, Ulrika, William-Olsson, Lena, Hartleib-Geschwindner, Judith, Bamberg, Krister
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
Get full text
Journal Article
Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system
Rigal, Sophie, Casas, Belén, Kanebratt, Kajsa P, Wennberg Huldt, Charlotte, Magnusson, Lisa U, Müllers, Erik, Karlsson, Fredrik, Clausen, Maryam, Hansson, Sara F, Leonard, Louise, Cairns, Jonathan, Jansson Löfmark, Rasmus, Ämmälä, Carina, Marx, Uwe, Gennemark, Peter, Cedersund, Gunnar, Andersson, Tommy B, Vilén, Liisa K
Published in Communications biology (18.07.2024)
Published in Communications biology (18.07.2024)
Get full text
Journal Article
Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs
Dasa, Siva Sai Krishna, Suzuki, Ryo, Mugler, Emily, Chen, Lanlin, Jansson-Löfmark, Rasmus, Michaëlsson, Erik, Lindfors, Lennart, Klibanov, Alexander L., French, Brent A., Kelly, Kimberly A.
Published in Nanomedicine (01.11.2017)
Published in Nanomedicine (01.11.2017)
Get full text
Journal Article