Tau and neurofilament light‐chain as fluid biomarkers in spinocerebellar ataxia type 3
Garcia‐Moreno, Hector, Prudencio, Mercedes, Thomas‐Black, Gilbert, Solanky, Nita, Jansen‐West, Karen R., Hanna AL‐Shaikh, Rana, Heslegrave, Amanda, Zetterberg, Henrik, Santana, Magda M., Pereira de Almeida, Luis, Vasconcelos‐Ferreira, Ana, Januário, Cristina, Infante, Jon, Faber, Jennifer, Klockgether, Thomas, Reetz, Kathrin, Raposo, Mafalda, Ferreira, Ana F., Lima, Manuela, Schöls, Ludger, Synofzik, Matthis, Hübener‐Schmid, Jeannette, Puschmann, Andreas, Gorcenco, Sorina, Wszolek, Zbigniew K., Petrucelli, Leonard, Giunti, Paola
Published in European journal of neurology (01.08.2022)
Published in European journal of neurology (01.08.2022)
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Comment on: Polyglutamine‐Expanded Ataxin‐3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood
Hanna AL‐Shaikh, Rana, Jansen‐West, Karen R., Petrucelli, Leonard, Wszolek, Zbigniew K., Prudencio, Mercedes
Published in Movement disorders (01.05.2022)
Published in Movement disorders (01.05.2022)
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Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency
Lee, Wing C, Almeida, Sandra, Prudencio, Mercedes, Caulfield, Thomas R, Zhang, Yong-Jie, Tay, William M, Bauer, Peter O, Chew, Jeannie, Sasaguri, Hiroki, Jansen-West, Karen R, Gendron, Tania F, Stetler, Caroline T, Finch, NiCole, Mackenzie, Ian R, Rademakers, Rosa, Gao, Fen-Biao, Petrucelli, Leonard
Published in Human molecular genetics (15.03.2014)
Published in Human molecular genetics (15.03.2014)
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Astrocyte-derived clusterin suppresses amyloid formation in vivo
Wojtas, Aleksandra M, Sens, Jonathon P, Kang, Silvia S, Baker, Kelsey E, Berry, Taylor J, Kurti, Aishe, Daughrity, Lillian, Jansen-West, Karen R, Dickson, Dennis W, Petrucelli, Leonard, Bu, Guojun, Liu, Chia-Chen, Fryer, John D
Published in Molecular neurodegeneration (27.11.2020)
Published in Molecular neurodegeneration (27.11.2020)
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Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor
Prudencio, Mercedes, Jansen-West, Karen R., Lee, Wing C., Gendron, Tania F., Zhang, Yong-Jie, Xu, Ya-Fei, Gass, Jennifer, Stuani, Cristiana, Stetler, Caroline, Rademakers, Rosa, Dickson, Dennis W., Buratti, Emanuele, Petrucelli, Leonard
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
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Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
Frew, Jonathan, Baradaran-Heravi, Alireza, Balgi, Aruna D, Wu, Xiujuan, Yan, Tyler D, Arns, Steve, Shidmoossavee, Fahimeh S, Tan, Jason, Jaquith, James B, Jansen-West, Karen R, Lynn, Francis C, Gao, Fen-Biao, Petrucelli, Leonard, Feldman, Howard H, Mackenzie, Ian R, Roberge, Michel, Nygaard, Haakon B
Published in Molecular neurodegeneration (16.03.2020)
Published in Molecular neurodegeneration (16.03.2020)
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Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Wojtas, Aleksandra M, Carlomagno, Yari, Sens, Jonathon P, Kang, Silvia S, Jensen, Tanner D, Kurti, Aishe, Baker, Kelsey E, Berry, Taylor J, Phillips, Virginia R, Castanedes, Monica Casey, Awan, Ayesha, DeTure, Michael, De Castro, Cristhoper H Fernandez, Librero, Ariston L, Yue, Mei, Daughrity, Lillian, Jansen-West, Karen R, Cook, Casey N, Dickson, Dennis W, Petrucelli, Leonard, Fryer, John D
Published in Acta neuropathologica communications (01.12.2020)
Published in Acta neuropathologica communications (01.12.2020)
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Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease
Jambeau, Melanie, Meyer, Kevin D, Hruska-Plochan, Marian, Tabet, Ricardos, Lee, Chao-Zong, Ray-Soni, Ananya, Aguilar, Corey, Savage, Kitty, Mishra, Nibha, Cavegn, Nicole, Borter, Petra, Lin, Chun-Chia, Jansen-West, Karen R, Jiang, Jie, Freyermuth, Fernande, Li, Nan, De Rossi, Pierre, Pérez-Berlanga, Manuela, Jiang, Xin, Daughrity, Lilian M, Pereira, João, Narayanan, Sarav, Gu, Yuanzheng, Dhokai, Shekhar, Dalkilic-Liddle, Isin, Maniecka, Zuzanna, Weber, Julien, Workman, Michael, McAlonis-Downes, Melissa, Berezovski, Eugene, Zhang, Yong-Jie, Berry, James, Wainger, Brian J, Kankel, Mark W, Rushe, Mia, Hock, Christoph, Nitsch, Roger M, Cleveland, Don W, Petrucelli, Leonard, Gendron, Tania F, Montrasio, Fabio, Grimm, Jan, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde
Published in Nevada RNformation (06.12.2022)
Published in Nevada RNformation (06.12.2022)
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Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models
Lim, Melina J, Boschen, Suelen L, Kurti, Aishe, Castanedes Casey, Monica, Phillips, Virginia R, Fryer, John D, Dickson, Dennis, Jansen-West, Karen R, Petrucelli, Leonard, Delenclos, Marion, McLean, Pamela J
Published in Biomedicines (01.10.2023)
Published in Biomedicines (01.10.2023)
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Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19
Erben, Young, Prudencio, Mercedes, Marquez, Christopher P., Jansen-West, Karen R., Heckman, Michael G., White, Launia J., Dunmore, Judith A., Cook, Casey N., Lilley, Meredith T., Qosja, Neda, Song, Yuping, Hanna Al Shaikh, Rana, Daughrity, Lillian M., Bartfield, Jordan L., Day, Gregory S., Oskarsson, Björn, Nicholson, Katharine A., Wszolek, Zbigniew K., Hoyne, Jonathan B., Gendron, Tania F., Meschia, James F., Petrucelli, Leonard
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila
De Mena, Lorena, Smith, Michael A, Martin, Jason, Dunton, Katie L, Ceballos-Diaz, Carolina, Jansen-West, Karen R, Cruz, Pedro E, Dillon, Kristy D, Rincon-Limas, Diego E, Golde, Todd E, Moore, Brenda D, Levites, Yona
Published in Alzheimer's research & therapy (17.10.2020)
Published in Alzheimer's research & therapy (17.10.2020)
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Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity
Nicholson, Alexandra M, Zhou, Xiaolai, Perkerson, Ralph B, Parsons, Tammee M, Chew, Jeannie, Brooks, Mieu, DeJesus-Hernandez, Mariely, Finch, NiCole A, Matchett, Billie J, Kurti, Aishe, Jansen-West, Karen R, Perkerson, Emilie, Daughrity, Lillian, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Hu, Fenghua, Gendron, Tania F, Murray, Melissa E, Dickson, Dennis W, Fryer, John D, Petrucelli, Leonard, Rademakers, Rosa
Published in Acta neuropathologica communications (31.05.2018)
Published in Acta neuropathologica communications (31.05.2018)
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Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19
Prudencio, Mercedes, Erben, Young, Marquez, Christopher P, Jansen-West, Karen R, Franco-Mesa, Camila, Heckman, Michael G, White, Launia J, Dunmore, Judith A, Cook, Casey N, Lilley, Meredith T, Song, Yuping, Harlow, Caroline F, Oskarsson, Björn, Nicholson, Katharine A, Wszolek, Zbigniew K, Hickson, LaTonya J, O'Horo, John C, Hoyne, Jonathan B, Gendron, Tania F, Meschia, James F, Petrucelli, Leonard
Published in Science Translational Medicine (14.07.2021)
Published in Science Translational Medicine (14.07.2021)
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Plasma neurofilament light predicts mortality in patients with stroke
Gendron, Tania F, Badi, Mohammed K, Heckman, Michael G, Jansen-West, Karen R, Vilanilam, George K, Johnson, Patrick W, Burch, Alexander R, Walton, Ronald L, Ross, Owen A, Brott, Thomas G, Miller, Timothy M, Berry, James D, Nicholson, Katharine A, Wszolek, Zbigniew K, Oskarsson, Björn E, Sheth, Kevin N, Sansing, Lauren H, Falcone, Guido J, Cucchiara, Brett L, Meschia, James F, Petrucelli, Leonard
Published in Science translational medicine (11.11.2020)
Published in Science translational medicine (11.11.2020)
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Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19
Erben, Young, Prudencio, Mercedes, Marquez, Christopher P., Jansen-West, Karen R., Heckman, Michael G., White, Launia J., Dunmore, Judith A., Cook, Casey N., Lilley, Meredith T., Qosja, Neda, Song, Yuping, Al Shaikh, Rana Hanna, Daughrity, Lillian M., Bartfield, Jordan L., Day, Gregory S., Oskarsson, Björn, Nicholson, Katharine A., Wszolek, Zbigniew K., Hoyne, Jonathan B., Gendron, Tania F., Meschia, James F., Petrucelli, Leonard
Published in iScience (19.04.2024)
Published in iScience (19.04.2024)
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Using leucine zipper to facilitate α-synuclein assembly
Jiang, Peizhou, Ko, Li-wen, Jansen, Karen R, Golde, Todd E, Yen, Shu-Hui
Published in The FASEB journal (01.09.2008)
Published in The FASEB journal (01.09.2008)
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Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3
Koike, Yuka, Jansen-West, Karen R., Hanna AL-Shaikh, Rana, Carlomagno, Yari, Song, Yuping, Dunmore, Judith A., LeDoux, Mark S., Friedman, Joseph H., Pena, Ashley B., Uitti, Ryan J., Zaremba, Jacek, van Gerpen, Jay A., Pfeiffer, Ronald F., Veerappan, Venka, Aiba, Ikuko, Hashimoto, Rina, Giles, Samuel S., Shah, Jaimin S., Tipton, Philip W., Huang, Josephine F., Wierenga, Klaas J., Aasly, Jan, Fryer, John D., Petrucelli, Leonard, Wszolek, Zbigniew K., Prudencio, Mercedes
Published in Parkinsonism & related disorders (01.08.2021)
Published in Parkinsonism & related disorders (01.08.2021)
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Overexpression of nicastrin increases Abeta production
Murphy, M Paul, Das, Pritam, Nyborg, Andrew C, Rochette, Marjorie J, Dodson, Mark W, Loosbrock, Nicole M, Souder, Terrance M, McLendon, Chris, Merit, Sami L, Piper, Siân C, Jansen, Karen R, Golde, Todd E
Published in The FASEB journal (01.06.2003)
Published in The FASEB journal (01.06.2003)
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TRIO gene segregation in a family with cerebellar ataxia
Hanna Al Shaikh, Rana, Caulfield, Thomas, Strongosky, Audrey J., Matthew, Mavis, Jansen-West, Karen R., Prudencio, Mercedes, Fryer, John D., Petrucelli, Leonard, Uitti, Ryan J., Wszolek, Zbigniew K.
Published in Neurologia i neurochirurgia polska (01.11.2018)
Published in Neurologia i neurochirurgia polska (01.11.2018)
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Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers
Finch, NiCole A, Wang, Xue, Baker, Matthew C, Heckman, Michael G, Gendron, Tania F, Bieniek, Kevin F, Wuu, Joanne, DeJesus-Hernandez, Mariely, Brown, Patricia H, Chew, Jeannie, Jansen-West, Karen R, Daughrity, Lillian M, Nicholson, Alexandra M, Murray, Melissa E, Josephs, Keith A, Parisi, Joseph E, Knopman, David S, Petersen, Ronald C, Petrucelli, Leonard, Boeve, Bradley F, Graff-Radford, Neill R, Asmann, Yan W, Dickson, Dennis W, Benatar, Michael, Bowser, Robert, Boylan, Kevin B, Rademakers, Rosa, van Blitterswijk, Marka
Published in Neurology. Genetics (01.08.2017)
Published in Neurology. Genetics (01.08.2017)
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